1. Concern regarding the alleged spread of hypervirulent lymphogranuloma venereum Chlamydia trachomatis strain in Europe
- Author
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Helena M. B. Seth-Smith, Bart Versteeg, Cécile Bébéar, Henry J. C. de Vries, Juan C. Galán, Ian Carter, David A. Lewis, Servaas A. Morré, Adrian Egli, Bertille de Barbeyrac, Sylvia M. Bruisten, Olivia Peuchant, Nicholas R. Thomson, Jen Kok, Daniel Goldenberger, Angèle Bénard, Clinical Microbiology, Hospital for Infectious Diseases, Applied Microbiology Research, Department of Biomedicine, University of Basel (Unibas), CIBER de Epidemiología y Salud Pública, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Western Sydney Sexual Health Centre, University of Sydney, USC 3671 Infections humaines à mycoplasmes et Chlamydiae, Institut National de la Recherche Agronomique (INRA), Université de Bordeaux (UB), The Wellcome Trust Sanger Institute [Cambridge], Centre for Infectious Disease and Microbiology (CIDM), The Westmead Institute for Medical Research, Department of Infectious Diseases, Public Health Service Amsterdam, STI Outpatient Clinic, Amsterdam Infection and Immunity Institute (AI&II), Academic Medical Centre, University of Amsterdam, Laboratory of Immunogenetics, Department of Medical Microbiology and Infection Control, VU University Amsterdam Medical Center, Institute for Public Health Genomics (IPHG), Department of Genetics and Cell Biology, Research Institute GROW, Maastricht University, London School of Hygiene and Tropical Medicine (LSHTM), Department of Dermatology, Academic Medical Center, AII - Infectious diseases, APH - Global Health, Medical Microbiology and Infection Prevention, APH - Methodology, Dermatology, RS: GROW - R4 - Reproductive and Perinatal Medicine, Institute for Public Health Genomics, University of Amsterdam [Amsterdam] (UvA), and Maastricht University [Maastricht]
- Subjects
0301 basic medicine ,bacterial outer membrane proteins ,Epidemiology ,OUTBREAK ,genotype ,[SDV]Life Sciences [q-bio] ,030106 microbiology ,Chlamydia trachomatis ,VARIANTS ,urologic and male genital diseases ,medicine.disease_cause ,03 medical and health sciences ,male homosexuality ,Virology ,Genotype ,Humans ,Medicine ,Homosexuality, Male ,lymphogranuloma venereum ,business.industry ,Strain (biology) ,Lymphogranuloma venereum ,Public Health, Environmental and Occupational Health ,Outbreak ,bacterial infections and mycoses ,medicine.disease ,female genital diseases and pregnancy complications ,3. Good health ,Europe ,030104 developmental biology ,Bacterial Outer Membrane Proteins ,Lymphogranuloma Venereum ,bacteria ,business ,Male Homosexuality - Abstract
A recent surveillance and outbreak report published in Eurosurveillance by Petrovay et al. on the ‘Emergence of the lymphogranuloma venereum L2c genovariant, Hungary, 2012 to 2016’ [1] provides an observation of the first European cases of a genotype of Chlamydia trachomatis associated with severe haemorrhagic proctitis. The authors of this paper diagnosed the strains as lymphogranuloma venereum (LGV)- associated and performed partial sequencing of the ompA gene (ca 1,070 bp), which is a standard typing method for C. trachomatis. The ompA gene sequence obtained was compared with those from reference isolates, and reported to be 100% concordant with the ompA sequence belonging to an L2-D recombinant strain described in 2011 [2]. This strain was named ‘L2c’, as it was found to possess a chimeric genome, not because it has a novel ompA-genotype. We would like to point out that the ompA gene sequence of this L2-D recombinant strain, and by implication those of the Hungarian isolates, is identical to that of archetypal L2 strains, for example the reference strain L2/434 [3].
- Published
- 2017
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