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21 results on '"Petrozza A."'

6. M2 muscarinic receptors inhibit cell proliferation and migration in urothelial bladder cancer cells

Author

Carbone, Antonio, Pastore, ANTONIO LUIGI, Velotti, Gennaro, AL SALHI, Yazan, Autieri, Domenico, Fuschi, Andrea, Ripoli, Andrea, Leto, Antonino, Petrozza, Vincenzo, and Palleschi, Giovanni

Subjects
Agonist, Bladder cancer, Cell growth, business.industry, medicine.drug_class, Urology, 030232 urology & nephrology, Muscarinic acetylcholine receptor M3, Muscarinic acetylcholine receptor M2, Arecaidine, urologic and male genital diseases, medicine.disease, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Transitional cell carcinoma, chemistry, 030220 oncology & carcinogenesis, Muscarinic acetylcholine receptor, Cancer research, Medicine, business
Abstract

The role of muscarinic receptors in several diseases including cancer has recently emerged. To evaluate the hypothesis that muscarinic acetylcholine receptors may play a role in bladder cancer as well as in other tumor types, we investigated their expression in bladder tumor specimens. All examined samples expressed the M1, M2 and M3 receptor subtypes. We also found that the level of M2 transcripts, but not those of M1 or M3, significantly increased with the tumor histologic grade. In view of these results, we proceeded to investigate whether the M2 agonist Arecaidine had any effect on in vitro cell growth and migration of T24 cells, a bladder tumor cell line expressing the muscarinic receptors, including the M2 subtype. We observed that Arecaidine significantly reduced T24 and 5637 cell proliferation and migration in a concentration dependent manner. The silencing of M2 receptor by siRNA in T24 and 5637 cell lines showed the inability of Arecaidine (100 mM) to inhibit cell proliferation after 48 hours, whereas the use of M1 and M3 antagonists in T24 appeared not to counteract the Arecaidine effect, suggesting that the inhibition of cell proliferation was directly dependent on M2 receptor activation. These data suggest that M2 muscarinic receptors may play a relevant role in bladder cancer and represent a new attractive therapeutic target.

Published
2017
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9. 517 Transurethral resection of prostate and the role of pharmacological treatment with dutasteride in decreasing surgical blood loss

Author

M. Valentini, Simone Mariani, F. Barrese, M. Cappa, Giovanni Palleschi, Antonio Carbone, Vincenzo Petrozza, and Antonio Luigi Pastore

Subjects
medicine.medical_specialty, business.industry, Urology, Dutasteride, Pharmacological treatment, Resection, chemistry.chemical_compound, medicine.anatomical_structure, Blood loss, chemistry, Prostate, Medicine, business
Published
2013
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18. 914 A prospective randomized study to compare functional outcomes of radiofrequency and ultracision scalpels in videolaparoscopic radical prostatectomy

Author

Antonio Luigi Pastore, Antonio Carbone, Domenico Autieri, Vincenzo Petrozza, Luigi Silvestri, Andrea Ripoli, Giovanni Palleschi, and Antonino Leto

Subjects
medicine.medical_specialty, business.industry, Prostatectomy, Urology, General surgery, medicine.medical_treatment, medicine, Prospective randomized study, business
Published
2013
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21. 696 Premature ejaculation: A prospective randomized study to compare pelvic floor rehabilitation and dapoxetine, a novel selective serotonin reuptake inhibitor

Author

Antonino Leto, F. Iori, L. Pacini, Antonio Luigi Pastore, Antonio Carbone, Vincenzo Petrozza, Giovanni Palleschi, and C. Leonardo

Subjects
business.industry, Urology, Serotonin reuptake inhibitor, Anesthesia, Premature ejaculation, medicine, Prospective randomized study, medicine.symptom, Dapoxetine, Pelvic floor rehabilitation, business, medicine.drug
Published
2012
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