19 results on '"Robotics"'
Search Results
2. V093 - Robotic radical cystectomy and nephroureterectomy for UC in double renal transplant recipent with FloRIN reconstruction.
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Marquis, A., Lavagno, F., Allasia, M., Oderda, M., Livoti, S., Marra, G., Soria, F., and Gontero, P.
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KIDNEY transplantation , *CYSTECTOMY , *ROBOTICS - Published
- 2024
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3. Long-term Oncological Outcomes from an Early Phase Randomised Controlled Three-arm Trial of Open, Robotic, and Laparoscopic Radical Cystectomy (CORAL).
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Khan, Muhammad Shamim, Omar, Kawa, Ahmed, Kamran, Gan, Christine, Van Hemelrijck, Mieke, Nair, Rajesh, Thurairaja, Ramesh, Rimington, Peter, and Dasgupta, Prokar
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CYSTECTOMY , *URINARY diversion , *BLADDER cancer , *CORALS , *LOG-rank test , *ROBOTICS - Abstract
The long-term oncological outcomes of laparoscopic (LRC) and robotic-assisted radical cystectomy (RARC) are still maturing compared with open radical cystectomy (ORC). To evaluate the 5-yr oncological outcomes of patients recruited into the randomised trial of Open, Laparoscopic and Robot Assisted Cystectomy (CORAL) and extracorporeal urinary diversion. A review of prospectively maintained database of 60 patients with muscle-invasive bladder cancer (MIBC) or high-risk nonmuscle-invasive bladder cancer (HRNMIBC) who were previously randomised in the CORAL trial to receive ORC, RARC, or LRC. This trial was designed to compare the perioperative and early oncological outcomes of these techniques. The outcomes of interest included 5-yr recurrence-free survival (RFS), cancer-specific survival (CSS), and overall survival (OS). Kaplan–Meier curves were used to plot the recurrence and survival data. The curves between RFS, CSS, and OS were compared using the log-rank test. A two-sided p value <0.05 was considered significant. Results were analysed on the basis of intention to treat. A total of 60 patients with either MIBC (n = 38) or HRNMIBC (n = 21) were randomised in the CORAL trial to receive ORC, RARC, or LRC. The 5-yr RFS was 60%, 58%, and 71%; 5-yr CSS was 64%, 68%, and 69%; and 5-yr OS was 55%, 65%, and 61% for ORC, RARC, and LRC, respectively. There was no significant difference in RFS, CSS, and OS between the three surgical arms. The principal limitation is the small sample size. There was no difference in 5-yr RFS, CSS, and OS rates of patients who underwent ORC, RARC, and LRC for management of bladder cancer. Minimally invasive techniques achieved equivalent oncological outcomes to the gold standard of ORC. However, the study was based at a single institution with a small sample size. Patients who agreed to participate in the randomised trial of either open, laparoscopic, or robotic-assisted radical cystectomy for bladder cancer did not have different cancer outcomes at 5 yr. Patients who agreed to participate in the randomised trial of either open, laparoscopic, or robot-assisted radical cystectomy for bladder cancer had equivalent cancer outcomes at 5 yr. [ABSTRACT FROM AUTHOR]
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- 2020
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4. V016 - Technique and outcomes from prostate capsule-sparing during robotic male cystectomy.
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Ta, A., Olphert, J., Tan, W., Alkhamees, M., Shaw, G., Sridhar, A., and Kelly, J.
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CYSTECTOMY , *PROSTATE , *ROBOTICS , *MALES - Published
- 2023
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5. A0158 - Comparing objective recovery of activity levels using wearable devices in open vs. intracorporeal robotic cystectomy: An analysis of the secondary outcomes of the iROC randomized trial.
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Khetrapal, P., Catto, J.W.F., Ambler, G., Williams, N.R., Al-Hammouri, T., Khan, M.S., Thurairaja, R., Nair, R., Nathan, S., Sridhar, A., Ahmed, I., Charlesworth, P., Blick, C., Cumberbatch, M.G., Hussain, S.A., Kotwal, S., Bains, P.S., Rowe, E., Koupparis, A., and Noon, A.P.
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SECONDARY analysis , *CYSTECTOMY , *ROBOTICS , *URINARY diversion - Published
- 2023
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6. Randomized Trial Comparing Open Radical Cystectomy and Robot-assisted Laparoscopic Radical Cystectomy: Oncologic Outcomes.
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Bochner, Bernard H., Dalbagni, Guido, Marzouk, Karim H., Sjoberg, Daniel D., Lee, Justin, Donat, Sheri M., Coleman, Jonathan A., Vickers, Andrew, Herr, Harry W., and Laudone, Vincent P.
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CYSTECTOMY , *BLADDER cancer treatment , *HEALTH outcome assessment , *URINARY diversion , *CANCER relapse , *CANCER treatment - Abstract
Abstract Background Open radical cystectomy (ORC) has proven to be an important component in the treatment of high-risk bladder cancer (BCa). ORC surgical morbidity remains high; therefore, minimally invasive surgical techniques have been introduced in an attempt to improve patient outcomes. Objective To compare cancer outcomes in BCa patients managed with ORC or robotic-assisted radical cystectomy (RARC). Design, setting, and participants A prospective, randomized trial was completed between 2010 and 2013. Patients were randomized to ORC/pelvic lymphadenectomy (PLND) or RARC/PLND, with all undergoing open/extracorporeal urinary diversion. Median follow-up was 4.9 (IQR: 3.9–5.9) yr after surgery among surviving patients. Outcome measurements and statistical analysis Secondary outcomes to the trial included recurrence-free, cancer-specific, and overall survival. Results and limitations The trial randomized 118 patients who underwent RC/PLND and urinary diversion. Sixty were randomized to RARC and 58 to ORC. Four RARC-assigned patients refused randomization and received ORC; however, an intention to treat analysis was performed. No differences were observed in recurrence (hazard ratio [HR]: 1.27 ; 95% confidence interval [CI]: 0.69–2.36; p = 0.4) or cancer-specific survival (p = 0.4). No difference in overall survival was observed (p = 0.8). However, the pattern of first recurrence demonstrated a nonstatistically significant increase in metastatic sites for those undergoing ORC (sub-HR [sHR]: 2.21; 95% CI: 0.96–5.12; p = 0.064) and a greater number of local/abdominal sites in the RARC-treated patients (sHR: 0.34; 95% CI: 0.12–0.93; p = 0.035). The major limitation to this study is that the trial was not powered to determine differences in cancer recurrences, survival outcomes, or patterns of recurrence. Conclusions The secondary outcomes from our randomized trial did not definitively demonstrate differences in cancer outcomes in patients treated with ORC or RARC. However, differences in observed patterns of first recurrence highlight the need for future studies. Patient summary Of 118 patients randomly assigned to undergo radical cystectomy/pelvic lymphadenectomy and urinary diversion, half were assigned to open surgery and half to robot-assisted techniques. We found no difference in risk of recurring or dying of bladder cancer between the two groups. Take Home Message In this secondary analysis of cancer outcomes from our randomized controlled trial, we did not find a difference in overall recurrence rates and cancer-specific survival between open radical cystectomy and robot-assisted radical cystectomy for high-risk bladder cancer. Variations in patterns of recurrence require further study. [ABSTRACT FROM AUTHOR]
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- 2018
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7. V018 - Robotic radical cystectomy in renal transplant patients: The indocyanine green (ICG) technique.
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Yee, C.H., Ng, T.C.K., Yuen, S.K.K., Tam, M.H.M., Teoh, J.Y.C., Chiu, P.K.F., Chan, C.K., and Ng, C.F.
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INDOCYANINE green , *KIDNEY transplantation , *CYSTECTOMY , *ROBOTICS , *PATIENTS - Published
- 2023
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8. A0764 - Should we limit robot-assisted radical cystectomy with totally intracorporeal urinary diversion to neobladder patients? Head to head comparison of outcomes between robotic vs. open ileal conduit and robotic vs. open neobladder.
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Mastroianni, R., Tuderti, G., Anceschi, U., Bove, A.M., Brassetti, A., Ferriero, M., Misuraca, L., Guaglianone, S., Gallucci, M., and Simone, G.
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URINARY diversion , *CYSTECTOMY , *SURGICAL robots , *ROBOTICS - Published
- 2022
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9. Long-term Oncologic Outcomes Following Robot-assisted Radical Cystectomy: Results from the International Robotic Cystectomy Consortium.
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Raza, Syed Johar, Wilson, Timothy, Peabody, James O., Wiklund, Peter, Scherr, Douglas S., Al-Daghmin, Ali, Dibaj, Shiva, Khan, Muhammad Shamim, Dasgupta, Prokar, Mottrie, Alex, Menon, Mani, Yuh, Bertram, Richstone, Lee, Saar, Matthias, Stoeckle, Michael, Hosseini, Abolfazl, Kaouk, Jihad, Mohler, James L., Rha, Koon-Ho, and Wilding, Gregory
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CYSTECTOMY , *URINARY diversion , *UROLOGICAL surgery , *ROBOTICS , *PATHOLOGY - Abstract
Background Long-term oncologic data on patients undergoing robot-assisted radical cystectomy (RARC) are limited and based largely on single-institution series. Objective Report survival outcomes of patients who underwent RARC ≥5 yr ago. Design, setting, and participants Retrospective review of the prospectively populated International Robotic Cystectomy Consortium multi-institutional database identified 743 patients with RARC performed ≥5 yr ago. Clinical, pathologic, and survival data at the latest follow-up were collected. Patients with palliative RARC were excluded. Final analysis was performed on 702 patients from 11 institutions in 6 countries. Intervention RARC. Outcome measurements and statistical analysis Outcomes of interest, recurrence-free survival (RFS), cancer-specific survival (CSS), and overall survival (OS) were plotted using Kaplan-Meier survival curves. A Cox proportional hazards model was used to identify factors that predicted outcomes. Results and limitations Pathologic organ-confined (OC) disease was found in 62% of patients. Soft tissue surgical margins (SMs) were positive in 8%. Median lymph node (LN) yield was 16, and 21% of patients had positive LNs. Median follow-up was 67 mo (interquartile range: 18–84 mo). Five-year RFS, CSS, and OS were 67%, 75%, and 50%, respectively. Non-OC disease and SMs were associated with poorer RFS, CSS, and OS on multivariable analysis. Age predicted poorer CSS and OS. Adjuvant chemotherapy and positive SMs were predictors of RFS (hazard ratio: 3.20 and 2.16; p < 0.001 and p < 0.005, respectively). Stratified survival curves demonstrated poorer outcomes for positive SM, LN, and non-OC disease. Retrospective interrogation and lack of contemporaneous comparison groups that underwent open radical cystectomy were major limitations. Conclusions The largest multi-institutional series to date reported long-term survival outcomes after RARC. Patient summary Patients who underwent robot-assisted radical cystectomy for bladder cancer have acceptable long-term survival. [ABSTRACT FROM AUTHOR]
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- 2015
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10. Systematic Review and Cumulative Analysis of Perioperative Outcomes and Complications After Robot-assisted Radical Cystectomy.
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Novara, Giacomo, Catto, James W.F., Wilson, Timothy, Annerstedt, Magnus, Chan, Kevin, Murphy, Declan G., Motttrie, Alexander, Peabody, James O., Skinner, Eila C., Wiklund, Peter N., Guru, Khurshid A., and Yuh, Bertram
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CYSTECTOMY , *SURGICAL robots , *SURGICAL complications , *SYSTEMATIC reviews , *PERIOPERATIVE care , *HEALTH outcome assessment - Abstract
Context Although open radical cystectomy (ORC) is still the standard approach, laparoscopic radical cystectomy (LRC) and robot-assisted radical cystectomy (RARC) have gained popularity. Objective To report a systematic literature review and cumulative analysis of perioperative outcomes and complications of RARC in comparison with ORC and LRC. Evidence acquisition Medline, Scopus, and Web of Science databases were searched using a free-text protocol including the terms robot-assisted radical cystectomy or da Vinci radical cystectomy or robot* radical cystectomy . RARC case series and studies comparing RARC with either ORC or LRC were collected. Cumulative analysis was conducted. Evidence synthesis The searches retrieved 105 papers. According to the different diversion type, overall mean operative time ranged from 360 to 420 min. Similarly, mean blood loss ranged from 260 to 480 ml. Mean in-hospital stay was about 9 d for all diversion types, with consistently high readmission rates. In series reporting on RARC with either extracorporeal or intracorporeal conduit diversion, overall 90-d complication rates were 59% (high-grade complication: 15%). In series reporting RARC with intracorporeal continent diversion, the overall 30-d complication rate was 45.7% (high-grade complication: 28%). Reported mortality rates were ≤3% for all diversion types. Comparing RARC and ORC, cumulative analyses demonstrated shorter operative time for ORC, whereas blood loss and in-hospital stay were better with RARC (all p values <0.003). Moreover, 90-d complication rates of any-grade and 90-d grade 3 complication rates were lower for RARC (all p values <0.04), whereas high-grade complication and mortality rates were similar. Conclusions RARC can be performed safely with acceptable perioperative outcome, although complications are common. Cumulative analyses demonstrated that operative time was shorter with ORC, whereas RARC may provide some advantages in terms of blood loss and transfusion rates and, more limitedly, for postoperative complication rates over ORC and LRC. Patient summary Although open radical cystectomy (RC) is still regarded as a standard treatment for muscle-invasive bladder cancer, laparoscopic and robot-assisted RC are becoming more popular. Robotic RC can be safely performed with acceptably low risk of blood loss, transfusion, and intraoperative complications; however, as for open RC, the risk of postoperative complications is high, including a substantial risk of major complication and reoperation. [ABSTRACT FROM AUTHOR]
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- 2015
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11. Systematic Review and Cumulative Analysis of Oncologic and Functional Outcomes After Robot-assisted Radical Cystectomy.
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Yuh, Bertram, Wilson, Timothy, Bochner, Bernie, Chan, Kevin, Palou, Joan, Stenzl, Arnulf, Montorsi, Francesco, Thalmann, George, Guru, Khurshid, Catto, James W.F., Wiklund, Peter N., and Novara, Giacomo
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ONCOLOGIC surgery , *SURGICAL robots , *CYSTECTOMY , *SYSTEMATIC reviews , *HEALTH outcome assessment , *LAPAROSCOPIC surgery - Abstract
Context Although open radical cystectomy (ORC) is still the standard approach, laparoscopic radical cystectomy (LRC) and robot-assisted radical cystectomy (RARC) are increasingly performed. Objective To report on a systematic literature review and cumulative analysis of pathologic, oncologic, and functional outcomes of RARC in comparison with ORC and LRC. Evidence acquisition Medline, Scopus, and Web of Science databases were searched using a free-text protocol including the terms robot-assisted radical cystectomy or da Vinci radical cystectomy or robot* radical cystectomy . RARC case series and studies comparing RARC with either ORC or LRC were collected. A cumulative analysis was conducted. Evidence synthesis The searches retrieved 105 papers, 87 of which reported on pathologic, oncologic, or functional outcomes. Most series were retrospective and had small case numbers, short follow-up, and potential patient selection bias. The lymph node yield during lymph node dissection was 19 (range: 3–55), with half of the series following an extended template (yield range: 11–55). The lymph node–positive rate was 22%. The performance of lymphadenectomy was correlated with surgeon and institutional volume. Cumulative analyses showed no significant difference in lymph node yield between RARC and ORC. Positive surgical margin (PSM) rates were 5.6% (1–1.5% in pT2 disease and 0–25% in pT3 and higher disease). PSM rates did not appear to decrease with sequential case numbers. Cumulative analyses showed no significant difference in rates of surgical margins between RARC and ORC or RARC and LRC. Neoadjuvant chemotherapy use ranged from 0% to 31%, with adjuvant chemotherapy used in 4–29% of patients. Only six series reported a mean follow-up of >36 mo. Three-year disease-free survival (DFS), cancer-specific survival (CSS), and overall survival (OS) rates were 67–76%, 68–83%, and 61–80%, respectively. The 5-yr DFS, CSS, and OS rates were 53–74%, 66–80%, and 39–66%, respectively. Similar to ORC, disease of higher pathologic stage or evidence of lymph node involvement was associated with worse survival. Very limited data were available with respect to functional outcomes. The 12-mo continence rates with continent diversion were 83–100% in men for daytime continence and 66–76% for nighttime continence. In one series, potency was recovered in 63% of patients who were evaluable at 12 mo. Conclusions Oncologic and functional data from RARC remain immature, and longer-term prospective studies are needed. Cumulative analyses demonstrated that lymph node yields and PSM rates were similar between RARC and ORC. Conclusive long-term survival outcomes for RARC were limited, although oncologic outcomes up to 5 yr were similar to those reported for ORC. Patient summary Although open radical cystectomy (RC) is still regarded as the standard treatment for muscle-invasive bladder cancer, laparoscopic and robot-assisted RCs are becoming more popular. Templates of lymph node dissection, lymph node yields, and positive surgical margin rates are acceptable with robot-assisted RC. Although definitive comparisons with open RC with respect to oncologic or functional outcomes are lacking, early results appear comparable. [ABSTRACT FROM AUTHOR]
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- 2015
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12. Best Practices in Robot-assisted Radical Cystectomy and Urinary Reconstruction: Recommendations of the Pasadena Consensus Panel.
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Wilson, Timothy G., Guru, Khurshid, Rosen, Raymond C., Wiklund, Peter, Annerstedt, Magnus, Bochner, Bernard H., Chan, Kevin G., Montorsi, Francesco, Mottrie, Alexandre, Murphy, Declan, Novara, Giacomo, Peabody, James O., Palou Redorta, Joan, Skinner, Eila C., Thalmann, George, Stenzl, Arnulf, Yuh, Bertram, and Catto, James
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CYSTECTOMY , *SURGICAL robots , *BLADDER , *PERIOPERATIVE care , *SURGICAL complications , *SYSTEMATIC reviews , *TRANSPLANTATION of organs, tissues, etc. - Abstract
Context Robot-assisted surgery is increasingly used for radical cystectomy (RC) and urinary reconstruction. Sufficient data have accumulated to allow evidence-based consensus on key issues such as perioperative management, comparative effectiveness on surgical complications, and oncologic short- to midterm outcomes. Objective A 2-d conference of experts on RC and urinary reconstruction was organized in Pasadena, California, and the City of Hope Cancer Center in Duarte, California, to systematically review existing peer-reviewed literature on robot-assisted RC (RARC), extended lymphadenectomy, and urinary reconstruction. No commercial support was obtained for the conference. Evidence acquisition A systematic review of the literature was performed in agreement with the PRISMA statement. Evidence synthesis Systematic literature reviews and individual presentations were discussed, and consensus on all key issues was obtained. Most operative, intermediate-term oncologic, functional, and complication outcomes are similar between open RC (ORC) and RARC. RARC consistently results in less blood loss and a reduced need for transfusion during surgery. RARC generally requires longer operative time than ORC, particularly with intracorporeal reconstruction. Robotic assistance provides ergonomic value for surgeons. Surgeon experience and institutional volume strongly predict favorable outcomes for either open or robotic techniques. Conclusions RARC appears to be similar to ORC in terms of operative, pathologic, intermediate-term oncologic, complication, and most functional outcomes. RARC consistently results in less blood loss and a reduced need for transfusion during surgery. RARC can be more expensive than ORC, although high procedural volume may attenuate this difference. Patient summary Robot-assisted radical cystectomy (RARC) is an alternative to open surgery for patients with bladder cancer who require removal of their bladder and reconstruction of their urinary tract. RARC appears to be similar to open surgery for most important outcomes such as the rate of complications and intermediate-term cancer-specific survival. Although RARC has some ergonomic advantages for surgeons and may result in less blood loss during surgery, it is more time consuming and may be more expensive than open surgery. [ABSTRACT FROM AUTHOR]
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- 2015
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13. Robot-assisted Radical Cystectomy: Description of an Evolved Approach to Radical Cystectomy.
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Collins, Justin W., Tyritzis, Stavros, Nyberg, Tommy, Schumacher, Martin, Laurin, Oscar, Khazaeli, Dinyar, Adding, Christofer, Jonsson, Martin N., Hosseini, Abolfazl, and Wiklund, N. Peter
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BLADDER cancer treatment , *CYSTECTOMY , *SURGICAL robots , *CANCER invasiveness , *URINARY diversion , *HEALTH outcome assessment - Abstract
Abstract: Background: Although open radical cystectomy (ORC) remains the gold standard of care for muscle-invasive bladder cancer, robot-assisted radical cystectomy (RARC) continues to gain wider acceptance. In this article, we focus on the steps of RARC, describing our approach, which has been developed over the past 10 yr. Totally intracorporeal RARC aims to offer the benefits of a complete minimally invasive approach while replicating the oncologic outcomes of open surgery. Objective: We report our outcomes of a totally intracorporeal RARC procedure, describing step by step our technique and highlighting the variations on this standard template of nerve-sparing and female organ–preserving approaches in men and women. Design, setting, and participants: Between December 2003 and October 2012, a total of 113 patients (94 male and 19 female) underwent totally intracorporeal RARC. Surgical procedure: We performed RARC, extended pelvic lymph node dissection, and a totally intracorporeal urinary diversion (UD) in all patients. In the accompanying video, we focus on the standard template for RARC, also describing nerve-sparing and female organ–preserving approaches. Outcome measurements and statistical analysis: Complications and oncologic outcomes are reported, including overall survival (OS) and cancer-specific survival (CSS) using Kaplan-Meier analysis. Results and limitations: RARC with intracorporeal UD was performed in 113 patients. Mean age was 64 yr (range: 37–84). Forty-three patients underwent intracorporeal ileal conduit, and 70 had intracorporeal neobladder. On surgical pathology, 48% of patients had ≤pT1 disease, 27% had pT2 disease, 13% had pT3 disease, and 12% had pT4 disease. The mean number of lymph nodes removed was 21 (range: 0–57). Twenty percent of patients had lymph node–positive disease. Positive surgical margins occurred in six cases (5.3%). Median follow-up was 25 mo (range: 3–107). We recorded a total of 70 early complications (0–30 d) in 54 patients (47.8%), with 37 patients (32.7%) having Clavien grade ≥3. Thirty-six late complications (>30 d) were recorded in 30 patients (26.5%), with 20 patients (17.7%) having Clavien grade ≥3. One patient (0.9%) died within 90 days of operation from pulmonary embolism. Using Kaplan-Meier analysis, CSS was 81% at 3 yr and 67% at 5 yr. Conclusions: Our structured approach to RARC has enabled us to develop this complex service while maintaining patient outcomes and complication rates comparable with ORC series. Our results demonstrate acceptable oncologic outcomes and encouraging long-term CSS rates. [Copyright &y& Elsevier]
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- 2013
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14. V75 - Radical cystectomy in renal transplant recipients: The advantages of the robotic approach.
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Soria, F., Allasia, M., Marquis, A., Calleris, G., Agnello, M., Giordano, A., Mazzoli, S., De Bellis, M., Rosazza, M., Livoti, S., Lillaz, B., and Gontero, P.
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KIDNEY transplantation , *CYSTECTOMY , *ROBOTICS - Published
- 2022
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15. V62 - Implementation of robotic radical cystectomy with intracorporeal neobladder reconstruction: Step-by-step description of the technique.
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Sighinolfi, M.C., Assumma, S., Morini, E., Del Nero, A., Piacentini, I., Mangiarotti, B., Maggioni, M., Puliatti, S., Picozzi, S., Bozzini, G., Micali, S., and Rocco, B.
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CYSTECTOMY , *ROBOTICS - Published
- 2022
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16. V66 - Robotic radical cystectomy with intracorporeal ileal conduit: Surgical technique, perioperative, functional and oncologic outcomes.
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Misuraca, L., Tuderti, G., Anceschi, U., Mastroianni, R., Brassetti, A., Ferriero, M., Bove, A.M., Guaglianone, S., Gallucci, M., and Simone, G.
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ILEAL conduit surgery , *OPERATIVE surgery , *CYSTECTOMY , *ROBOTICS - Published
- 2022
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17. V40 - Robotic management of surgical complications after robot-assisted radical cystectomy with intracorporeal diversion.
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Misuraca, L., Mastroianni, R., Tuderti, G., Anceschi, U., Brassetti, A., Ferriero, M., Bove, A.M., Guaglianone, S., Gallucci, M., and Simone, G.
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SURGICAL complications , *SURGICAL robots , *CYSTECTOMY , *URINARY diversion , *ROBOTICS - Published
- 2022
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18. Long-term Outcomes of Robot-assisted Radical Cystectomy for Bladder Cancer.
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Khan, Muhammad Shamim, Elhage, Oussama, Challacombe, Benjamin, Murphy, Declan, Coker, Bola, Rimington, Peter, O’Brien, Timothy, and Dasgupta, Prokar
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SURGICAL robots , *CYSTECTOMY , *BLADDER cancer treatment , *URINARY diversion , *HEALTH outcome assessment , *BCG vaccines - Abstract
Abstract: Background: Long-term oncologic and functional outcomes after robot-assisted radical cystectomy (RARC) for bladder cancer (BCa) are lacking. Objective: To report oncologic and functional outcomes in a cohort of patients who have completed a minimum of 5 yr and a maximum of 8 yr of follow-up after RARC and extracorporeal urinary diversion. Design, setting, and participants: In this paper, we report on the experience from one of the first European urology centres to introduce RARC. Only patients between 2004 and 2006 were included to ensure follow-up of ≥5 yr. We report on an analysis of oncologic outcomes in 14 patients (11 males and 3 females) with muscle-invasive/high-grade non–muscle-invasive or bacillus Calmette-Guérin–refractory carcinoma in situ who opted to have RARC. Intervention: RARC with pelvic lymphadenectomy was performed using the three-arm standard da Vinci Surgical System (Intuitive Surgical, CA, USA). Urinary diversion, either ileal conduit (n =12) or orthotopic neobladder (n =2), was constructed extracorporeally. Outcome measurements: Parameters were recorded in a prospectively maintained database including assessment of renal function, overall survival, disease-specific survival, development of metastases, and functional outcomes. Statistical analysis: Results were analysed using descriptive statistical analysis. Survival data were analysed and presented using the Kaplan-Meier survival curve. Results and limitations: Five of the 14 patients have died. Three patients died of metastatic disease, and two died of unrelated causes. Two other patients are alive with metastases, and another has developed primary lung cancer. Six patients are alive and disease-free. These results show overall survival of 64%, disease-specific survival of 75%, and disease-free survival of 50%. None of the patients had deterioration of renal function necessitating renal replacement therapy. Three of four previously potent patients having nerve-sparing RARC recovered erectile function. The study is limited by the relatively small number of highly selected patients undergoing RARC, which was a novel technique 8 yr ago. The standard da Vinci Surgical System made extended lymphadenectomy difficult. Conclusions: Within limitations, in our experience RARC achieved excellent control of local disease, but the outcomes in patients with metastatic disease seem to be equivalent to the outcomes of open radical cystectomy. [Copyright &y& Elsevier]
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- 2013
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19. Re: Adam C. Calaway, Lawrence H. Einhorn, Timothy A. Masterson, Richard S. Foster, Clint Cary. Adverse Surgical Outcomes Associated with Robotic Retroperitoneal Lymph Node Dissection Among Patients with Testicular Cancer. Eur Urol 2019;76:607–9.
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Nason, Gregory J., Jewett, Michael A.S., and Hamilton, Robert J.
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LYMPHADENECTOMY , *CYSTECTOMY , *ROBOTICS , *TESTICULAR cancer , *CANCER patients - Published
- 2019
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