1. Global cardiovascular risk, COVID-19 severity and post-COVID-19 syndrome: a clinical study.
- Author
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Zaccone V, Falsetti L, Santoro L, Guerrieri E, Santini S, Viticchi G, Tosato M, Danese M, Miro C, Cataldi S, Gasbarrini A, Landi F, Santoliquido A, and Moroncini G
- Subjects
- Humans, Post-Acute COVID-19 Syndrome, SARS-CoV-2, Acute Disease, Risk Factors, Heart Disease Risk Factors, COVID-19, Cardiovascular Diseases epidemiology
- Abstract
Objective: Post-COVID-19 is a syndrome defined by signs and symptoms present until 12 weeks after COVID-19, lasting for more than 8 weeks, not explained by an alternative diagnosis. The present study aimed to assess whether the cardiovascular risk (CVR) of patients with COVID-19 correlates with symptoms and changes in respiratory function parameters in post-COVID-19. The association between CVR and the severity of acute disease was also considered., Patients and Methods: Between 21/04/21-01/09/21, we enrolled 1,782 consecutive patients with COVID-19. We divided these subjects into (i) 4 levels, based on the severity of COVID-19 (home care; hospitalized/no oxygen therapy; hospitalized/oxygen therapy; hospitalized/NIV-ICU), (ii) 2 levels, according to CVR calculated with the European Society of Cardiology SCORE tables (low-intermediate risk; high or very high risk). All subjects underwent a 3-month follow-up considering post-COVID-19 symptoms., Results: In post-COVID-19 patients, high or very-high CVR was associated with (i) increased risk of hospitalization for COVID-19 (p<0.0001), (ii) higher prevalence of severe clinical manifestations and ICU admission (p<0.0001), (iii) development of post-COVID-19 (p<0.0001) and (iv) increased risk of a larger post-COVID-19 burden of disease., Conclusions: We found a statistically significant association between CVR, severity of COVID-19, and post-COVID-19 syndrome three months after the end of acute disease.
- Published
- 2023
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