1. Characteristics and outcome of patients with second primary lung cancer
- Author
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Sonja Kobinger, Felix J.F. Herth, Helge Bischoff, Philipp A. Schnabel, Thomas Muley, Patrick Stumpf, Arne Warth, Andreas Stumpf, Michael Thomas, Niels Reinmuth, and Hans Hoffmann
- Subjects
Adult ,Male ,Risk ,Pulmonary and Respiratory Medicine ,Oncology ,medicine.medical_specialty ,Lung Neoplasms ,Biopsy ,Young Adult ,Carcinoma, Non-Small-Cell Lung ,Internal medicine ,Carcinoma ,Humans ,Medicine ,Stage (cooking) ,Young adult ,Lung cancer ,Aged ,Neoplasm Staging ,Retrospective Studies ,Aged, 80 and over ,medicine.diagnostic_test ,business.industry ,Smoking ,Neoplasms, Second Primary ,Retrospective cohort study ,Second primary cancer ,Middle Aged ,Prognosis ,medicine.disease ,Treatment Outcome ,Second Malignancy ,Female ,business ,Follow-Up Studies - Abstract
Patients with lung cancer are at risk of developing a second primary lung cancer (SPLC). However, the characteristics of patients at risk remain largely speculative. We reviewed 2816 lung cancer patients from our institution for the occurrence of SPLC. Any SPLC was categorised as synchronous when diagnosed within 2 years of the first primary lung cancer (FPLC) and after direct histological comparison of both tumours. All other SPLCs were considered as metachronous. 139 patients developed a second malignancy including 69 nonsmall cell lung cancer (NSCLC) and 9 small cell lung cancer. The median interval for diagnosis of metachronous SPLC (n=59) after FPLC occurrence was 72 months. SPLC detected within 5 years of FPLC diagnosis had a more favourable stage distribution (p=0.02). After diagnosis of SPLC, patients had a superior median overall survival compared to controls (57.7 versus 18.1 months; p
- Published
- 2012
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