33 results on '"Saifuddin"'
Search Results
2. Image-guided core needle biopsy for Ewing sarcoma of bone: a 10-year single-institution review
- Author
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Kalus, Sarah, Vidoni, Alessandro, Oliveira, Inês, and Saifuddin, Asif
- Published
- 2020
- Full Text
- View/download PDF
3. Whole-body MRI vs bone scintigraphy in the staging of Ewing sarcoma of bone: a 12-year single-institution review
- Author
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Kalus, Sarah and Saifuddin, Asif
- Published
- 2019
- Full Text
- View/download PDF
4. The value of re-staging chest CT at first local recurrence of extremity and trunk soft tissue sarcoma
- Author
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Ban Sharif, Daniel Lindsay, Bhavin Upadhyay, Asif Saifuddin, Wais Habib, Mirza Shaheer Baig, and Veronica Attard
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Soft Tissue Neoplasms ,030218 nuclear medicine & medical imaging ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Child ,Aged ,Retrospective Studies ,Neuroradiology ,Aged, 80 and over ,medicine.diagnostic_test ,business.industry ,Soft tissue sarcoma ,Soft tissue ,Extremities ,Sarcoma ,Interventional radiology ,Myxofibrosarcoma ,General Medicine ,Middle Aged ,medicine.disease ,Synovial sarcoma ,030220 oncology & carcinogenesis ,Female ,Radiology ,Spindle cell sarcoma ,Neoplasm Recurrence, Local ,Tomography, X-Ray Computed ,business - Abstract
To determine the prevalence of pulmonary metastases on re-staging chest CT at the time of first local recurrence (LR) of trunk or extremity soft tissue sarcoma (STS). Retrospective review of all patients diagnosed with recurrent STS between May 2007 and April 2018. Data collected included patient age and sex, site of primary STS, time to LR, recurrence site, initial tumour grade, recurrent tumour grade, findings of initial staging chest CT, and prevalence of pulmonary metastases on re-staging chest CT. The study included 109 patients (males = 68, females = 41; mean age 56 years, range 9–92 years). The commonest tumour sub-types were myxofibrosarcoma (27.5%), undifferentiated pleomorphic/spindle cell sarcoma (20.2%), synovial sarcoma (10.1%), and malignant peripheral nerve sheath tumour (10.1%). Initial staging chest CT demonstrated pulmonary metastases in 1 of 77 (1.3%) patients for whom CT was available for review. The mean time to LR was 30.8 months (range 3–224 months). Pulmonary metastases were diagnosed on re-staging chest CT in 26 of 109 cases (23.9%), being commonest with grade 3 STS (36.1%). Pleomorphic sarcoma (85.7%) and undifferentiated spindle cell sarcoma (33.3%) were the 2 commonest tumour sub-types associated with pulmonary metastases at first LR. Re-staging chest CT at the time of first LR of STS identified a prevalence of 23.9% pulmonary metastases, which supports the need for chest CT at the time of LR in line with the UK guidelines for the management of bone and soft tissue sarcoma. • Pulmonary metastases were diagnosed in 1.3% of soft tissue sarcomas at presentation. • Pulmonary metastases were identified in ~ 24% of patients at first local recurrence of soft tissue sarcoma, most commonly with pleomorphic sarcoma and Trojani grade tumours. • No patient with a low-grade recurrence had pulmonary metastases.
- Published
- 2020
5. MRI differentiation of low-grade from high-grade appendicular chondrosarcoma
- Author
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Douis, Hassan, Singh, Leanne, and Saifuddin, Asif
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- 2014
- Full Text
- View/download PDF
6. Lymphoma presenting as a musculoskeletal soft tissue mass: MRI findings in 24 cases
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Suresh, S., Saifuddin, A., and O’Donnell, P.
- Published
- 2008
- Full Text
- View/download PDF
7. Fluid-fluid levels in bone neoplasms: variation of T1-weighted signal intensity of the superior to inferior layers—diagnostic significance on magnetic resonance imaging
- Author
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Alyas, Faisal and Saifuddin, Asif
- Published
- 2008
- Full Text
- View/download PDF
8. The role of MR imaging in the diagnostic characterisation of appendicular bone tumours and tumour-like conditions
- Author
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Alyas, F., James, S. L., Davies, A. M., and Saifuddin, A.
- Published
- 2007
- Full Text
- View/download PDF
9. Characterisation of intra-articular soft tissue tumours and tumour-like lesions
- Author
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Adams, Matthew E. and Saifuddin, Asif
- Published
- 2007
- Full Text
- View/download PDF
10. Soft-tissue masses in the shoulder girdle: an imaging perspective
- Author
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Harish, Srinivasan, Saifuddin, Asif, and Bearcroft, Philip W. P.
- Published
- 2007
- Full Text
- View/download PDF
11. Soft tissue masses with “cyst-like” appearance on MR imaging: distinction of benign and malignant lesions
- Author
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Harish, Srinivasan, Lee, Justin C., Ahmad, Muaaze, and Saifuddin, Asif
- Published
- 2006
- Full Text
- View/download PDF
12. Image-guided percutaneous biopsy of intramedullary lytic bone lesions: utility of aspirated blood clots
- Author
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Harish, Srinivasan, Hughes, Richard J., Saifuddin, Asif, and Flanagan, Adrienne M.
- Published
- 2006
- Full Text
- View/download PDF
13. MR imaging of autologous chondrocyte implantation of the knee
- Author
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James, S. L. J., Connell, D. A., Saifuddin, A., Skinner, J. A., and Briggs, T. W. R.
- Published
- 2006
- Full Text
- View/download PDF
14. Imaging features of spinal osteoid osteoma with emphasis on MRI findings
- Author
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Harish, Srinivasan and Saifuddin, Asif
- Published
- 2005
- Full Text
- View/download PDF
15. The value of re-staging chest CT at first local recurrence of extremity and trunk soft tissue sarcoma
- Author
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Baig, Mirza S., primary, Habib, Wais, additional, Attard, Veronica, additional, Sharif, Ban, additional, Lindsay, Daniel, additional, Upadhyay, Bhavin, additional, and Saifuddin, Asif, additional
- Published
- 2020
- Full Text
- View/download PDF
16. Non-communicating intramuscular ganglia
- Author
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Beggs, I., Saifuddin, A., and Limb, D.
- Published
- 1998
- Full Text
- View/download PDF
17. The 3rd annual congress of the European society of skeletal radiology
- Author
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Bloem, J. L., Geirnaerdt, M. J. A., Hogendoorn, P. C. W., Chevrot, A., Davies, A. M., Hájek, M., Kurková, D., Herynek, V., Imhof, H., Masciocchi, C., Maffey, M. V., Møller, J. F., Putz, R., Reiser, M. F., Braunschweig, R., Bonél, H., Stäbler, A., Watt, I., Adams, J. E., Harake, M. D. J., Lipscomp, K., Selby, P. L., Aparisi, F., Arana, E., Lloret, R. M., Marti-Bonmati, I., Menor, F., Sanchez, E., Rodrigo, C., Beltran, J., Cifrian, C., Garci, J. L., Memis, A., Arkun, R., Akalin, T., Ustu, E. E., Sabah, D., Barile, A., Rossi, F., Zugaro, L., Manetta, R., Maurizi Enrici, R., Beggs, I., Bianchi, S., Martinoli, C., Molini, L., Gandolfo, N., Damiani, S., Helmberger, T., Sittek, H., Steinborn, M., Ritter, M. M., Geisst, H. C., Pistitsch, C., Herrmann, K., Bögl, K., Kainberger, F., Adlassnig, K. P., Kolousek, G., Leitich, H., Kolarz, G., Bracke, P., Ramon, F., Stevens, W., De Clarck, L., De Schepper, A., Sys, J., Michielsen, J., Martens, M., Breitenseher, M. J., Trattnig, S., Gaebler, C., Metz, V., Kukla, C., Gneger, A., Rand, T., Brossmann, J., Andresen, R., Preidler, K. W., Daenen, B., DeMaeseneer, M., Resnick, D., Burnett, S., Saifuddin, A., White, J., Cassar-Pullicino, V. N., Inman, C., Griffiths, J., McCall, I. W., Masri, W. E., Csókási, Z., Forgacs, S., Czerny, C., Neuhold, A., Hofmann, S., Tschauner, C., Engel, A., Recht, M. P., Kramer, J., DeBeuckeleer, L., DeSchepper, A., Somerville, J., Vandevenne, J., De Maeseneer, M., Jaovishidha, S., Sartoris, D. J., Elizagaray, E., Saez, F., Faletti, C., De Stefano, N., Sorrentin, T., Foderà Pierangeli, L., Mona, D., Foster, J. E., Taberner, J., Keen, M., Dieppe, P., Freyschmidt, J., Gibbon, W. W., O'Connor, P. J., McGonagle, D., Emery, P., Grampp, S., Lang, P., Jergas, M., Glüer, C. C., Steiner, E., Takada, M., Mathur, A., Genant, H. K., Jevtic, V., Rozman, B., Kos-Golja, M., Demsar, F., Nehrer, S., Seidl, G., Baldt, M., Klarlund, M., Østergaard, M., Sørensen, K., Lorenzen, I., Eschberger, J., Gstettner, M., Schneider, W., Plenk, H., Kühne, J. H., Steinborn, A., Dürr, H. R., Scheidler, J., Lienemann, A., Landsiedl, F., Mamdorff, P., Honda, G., Rosenau, W., Johnston, J., Mindell, E., Peterfy, C. G., Nevitt, M., Majumdar, S., Lecouvet, F. E., Vande Berg, B. C., Maighem, J., Michaux, J. L., Maldague, B. E., Lecoevet, F. E., Malghem, J., Mastantuono, M., Larciprete, M., Bassetti, E., Argento, G., Amoroso, M., Satragno, L., Nucci, F., Romanini, L., Passariello, R., McNally, E. G., Goodman, T. R., Merkle, E. M., Krammel, E., Vogel, J., Krämer, S., Schulte, M., Usadel, S., Kern, P., Brambs, H. J., Mester, Á., Makó, E., Papp, E., Kiss, K., Márton, E., Dévai, T., Duffek, L., Bártfai, K., Németh, L., Karlinger, K., Posgay, M., Kákosy, T., Davies, G. A., Cowen, A. R., Fowler, R. C., Bury, R. F., Parkin, G. J. S., Lintott, D. J., Martinez, D., Safadin, A., Pal, C. R., Ostlere, S. J., Phillps, A. J., Athanasou, N., Lemperle, S. M., Holmes, R. E., Rühm, S., Zanetti, M., Romero, J., Hodler, J., Larena, J. A., Marti-Bonmarti, L., Martin, I., Tabernero, G., Alonso, A., Scarabino, T., Guglielmi, G., Giannatempo, G. M., Cammisa, M., Salvolini, U., Schmitt, R., Fellner, F., Heinze, A., Obletter, N., Schnarkowski, P., Tirman, P. F. J., Steinbach, L. S., Schneider, P., Ferrettiz, J. L., Capozza, R. F., Braun, M., Reiners, C., Zettl, R., Silvestri, E., Falchi, M., Delucchi, S., Cella, R., Neumaier, C. E., Prato, N., Migliorini, S., Jessel, C., Heuck, A., Stevens, K. J., Preston, B. J., Kerslake, R. W., Wright, W., Wallace, W. A., Stiskal, M., Szolar, D., Stenzel, I., Mesaric, P., Smolen, J., Czembirek, H., Tasker, A. D., Benson, M. K., Fleischmann, D., Haller, J., Rottmann, B., Kontaxis, G., Vanel, D., Missenard, G., Le Cesne, A., Guinebretiere, J. M., Verhoek, G., Duewell, S., Zollinger, H., Vrooman, H. A., Valstar, E. R., Brand, G. J., Obermann, W. R., Rozing, P. M., Reiber, J. H. C., Zafiroski, G., Kamnar, J., Zografski, G., Jeftic, V., Vidoevski, G., Ledermann, T., Zerbi, A., Gambaretti, R., Trenti, N., Zanolla, W., Allen, A. W., Willis, Ch. E., Radmer, S., Hakim, S., Banzer, D., Sparmann, M., Argent, J. D., Sampson, M. A., Baur, A., Bartl, R., Llopis, E., Monton, T., Vallcanera, A., Serafini, G., Bertolotto, M., Trudell, D., White, L. M., Garlaschi, G., DiLella, G. M., Bray, A., Parrella, A., Salvia, F., Parrella, R. E., Esztergályos, J., Faul, S., Link, J., Behrendt, S., Helbich, T., Steingruber, I., Gahleitner, A., Kettenbach, J., Kreuzer, S., Lomoschitz, F., Kaposi, P. N., Reti, P. G., Kolenc, M., Turk, Z., Barovic, J., Kugler, Ch., Uggowitzer, M., Gröll, R., Raith, J., Ranner, G., Liskutin, J., Youssefzadeh, S., Montagnon, C., Billiard, J. S., Tanji, P., Peerally, S., Gazielly, D., Muhaz-Vives, J. M., Fernández, J., Girveni-Montilos, R., Catasuz-Capellades, X., Valls-Pascual, R., Niitsu, M., Mishima, H., Itai, Y., Pirronti, T., Sallustio, G., Cerase, A., Priolo, F., Poleksic, L., Atanackovic, M., Dimitrijevic, B., Bacic, G., Potsybina, V. V., Rangger, Ch., Kathrein, A., Klestil, T., Gabl, M., Daniaux, H., Recondo, J. A., Alustiza, J. M., Villanua, J., Barrera, M. C., Salvador, E., Larrea, J. A., and Martin, J.
- Published
- 1996
- Full Text
- View/download PDF
18. Whole-body MRI vs bone scintigraphy in the staging of Ewing sarcoma of bone: a 12-year single-institution review
- Author
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Sarah Kalus and Asif Saifuddin
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Long bone ,Bone Neoplasms ,Sarcoma, Ewing ,Scintigraphy ,030218 nuclear medicine & medical imaging ,Metastasis ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Cranial vault ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Whole Body Imaging ,Child ,Radionuclide Imaging ,Neuroradiology ,Neoplasm Staging ,Retrospective Studies ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,General Medicine ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,medicine.anatomical_structure ,Bone scintigraphy ,030220 oncology & carcinogenesis ,Child, Preschool ,Female ,Radiology ,Sarcoma ,business ,Follow-Up Studies ,Forecasting - Abstract
To compare whole-body MRI (WB-MRI) at 1.5/3T and bone scintigraphy in the skeletal staging of Ewing sarcoma (ES) of bone. All patients with a histological diagnosis of ES of bone between 2007 and 2018 were retrospectively reviewed. The analysis included gender, mean age, skeletal distribution, and prevalence of skeletal metastases on WB-MRI and bone scintigraphy. The study group comprised 182 patients with a mean age of 18.0 years (range 2–56 years), 126 males and 56 females. Skeletal metastases were detected overall in 30 patients (16.5%), in 23 of 96 patients (24%) who underwent WB-MRI, and in 20 of 118 patients (16.9%) who underwent bone scintigraphy. Of 71 patients who underwent both WB-MRI and bone scintigraphy, skeletal metastases were detected on both modalities in 13 (18.3%), while in 4 patients, skeletal metastases were identified on WB-MRI alone. There were no patients in whom skeletal metastases were identified on bone scintigraphy alone. Of 13 patients with skeletal metastases who underwent both studies, WB-MRI showed a greater number of metastatic foci in 10 (76.9%). However, scintigraphy was superior to WB-MRI in detecting skull vault lesions, but did show false-positive results around the long bone growth plates. WB-MRI is more sensitive than bone scintigraphy in detecting skeletal metastases in ES of bone, with the exception of skull vault metastases. Consideration should be given to replacing bone scintigraphy with WB-MRI. • Whole-body MRI is more sensitive than bone scintigraphy in detecting skeletal metastases in Ewing sarcoma of bone. • Whole-body MRI can safely replace bone scintigraphy for staging of the skeleton, with the acknowledgement of the possibility of missing a clinically occult skull vault metastasis.
- Published
- 2018
19. Fluid-fluid levels in bone neoplasms: variation of T1-weighted signal intensity of the superior to inferior layers—diagnostic significance on magnetic resonance imaging
- Author
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Asif Saifuddin and Faisal Alyas
- Subjects
Adult ,Male ,medicine.medical_specialty ,Bone Neoplasms ,Malignancy ,Sensitivity and Specificity ,Bone tumours ,Biopsy ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Neuroradiology ,medicine.diagnostic_test ,business.industry ,Ultrasound ,Reproducibility of Results ,Magnetic resonance imaging ,Histology ,General Medicine ,medicine.disease ,Magnetic Resonance Imaging ,Body Fluids ,Female ,Radiology ,Signal intensity ,business - Abstract
The diagnostic relevance of the relative T1-weighted (T1W) and T2-weighted (T2W)/short tau inversion recovery (STIR) MRI signal intensity characteristics of the superior to inferior fluid layers within fluid-fluid levels (FFLs) found in bone tumours was investigated. A retrospective analysis was performed of MRI studies of 2,568 patients presenting with a suspected bone tumour over an 8-year period. Final diagnosis was made by biopsy/surgical resection or characteristic imaging/clinical findings. Subjects were divided by the absence/presence of FFLs and benign/malignant histology. Cases with FFLs were sub-categorised by the relative signal intensity of the superior/inferior layer as high/low or low/high on T1W and T2W/STIR sequences. Out of the total of 2,568 cases, 214 (8.3%, CI 7.3-9.5%) had FFLs and 2,354 (91.7%, CI 90.5-92.7%) had no FFLs. All 214 cases with FFLs had T2W/STIR sequences available, all demonstrating high/low signal intensity characteristics; 135/214 (63.1%, CI 56.2-69.6%) were benign and 79/214 (36.9%, CI 30.4-43.8%) were malignant. Out of the 214 patients, 151 had T1W sequences performed; 52 showed high/low signal intensity, of which 30 (57.7%, CI 34.2-71.3%) were benign and 22 (42.3%, CI 28.7-56.8%) were malignant (P = 0.06 compared with no FFL group); 50 showed low/high signal intensity, of which 40 (80%, CI 66.3-90.0%) were benign and ten (20%, CI 10.0-33.7%) were malignant (P = 0.0000, compared with the no FFL group). The low/high and high/low groups had a significantly greater proportion of benign and malignant lesions, respectively (P = 0.015). In conclusion, all FFLs showed high/low signal intensity characteristics on T2W/STIR sequences. Low/high signal on T1W was significantly associated with benign disease. Malignancy may occur slightly more frequently with high/low signal on T1W.
- Published
- 2008
20. Characterisation of intra-articular soft tissue tumours and tumour-like lesions
- Author
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Matthew E. Adams and A. Saifuddin
- Subjects
Male ,medicine.medical_specialty ,Pathology ,Soft Tissue Neoplasm ,Soft Tissue Neoplasms ,Diagnosis, Differential ,Synovial osteochondromatosis ,Synovitis ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Range of Motion, Articular ,Retrospective Studies ,Neuroradiology ,medicine.diagnostic_test ,business.industry ,Soft tissue ,Magnetic resonance imaging ,General Medicine ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Radiography ,Pigmented villonodular synovitis ,Female ,Radiology ,Differential diagnosis ,business ,Chondromatosis, Synovial - Abstract
The aim of this study was to describe a new magnetic resonance imaging (MRI) classification system for intra-articular soft tissue tumours based on the morphology of the lesion, with the aim to aid the differential diagnosis. We performed a retrospective review of 52 consecutive patients presenting to a specialist musculoskeletal oncology unit with a suspected intra-articular tumour. Lesions were categorised into one of four groups according to a simple classification system based on their morphological features on MRI. Distinct groupings of pathologies emerged corresponding to each of the morphological categories. Particularly when combined with radiographic features of calcification and bone erosion, certain patterns were found to be characteristic of specific diagnoses. For example multifocal, calcified lesions were found exclusively in synovial osteochondromatosis and diffuse synovitis with hypointense T2-weighted signal intensity was typical of pigmented villonodular synovitis. Certain combinations of imaging features such as diffuse solid lesions and focal lesions with bone erosion were commonly associated with malignant lesions. We suggest that by classifying intra-articular masses according to their morphological features on MRI, particularly when combined with simple radiographic features, an additional parameter may be generated to aid the radiologist in making a diagnosis. In addition, particular combinations of features provide 'red flags' to increase the index of suspicion for malignancy.
- Published
- 2006
21. Soft tissue masses with 'cyst-like' appearance on MR imaging: distinction of benign and malignant lesions
- Author
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Srinivasan Harish, A. Saifuddin, Justin C. Lee, and Muaaze Ahmad
- Subjects
Adult ,Male ,medicine.medical_specialty ,Soft Tissue Neoplasms ,Malignancy ,Statistics, Nonparametric ,Diagnosis, Differential ,Lesion ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Cyst ,Aged ,Neuroradiology ,Aged, 80 and over ,Cysts ,business.industry ,Soft tissue sarcoma ,Reproducibility of Results ,Soft tissue ,Myxoma ,General Medicine ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Ganglion cyst ,Logistic Models ,Female ,Radiology ,medicine.symptom ,business - Abstract
The purpose of this study was to assess the reliability of MR imaging features in distinguishing between benign and malignant soft tissue masses that have a "cyst-like" appearance (hypointense to muscle on T1-weighted and hyperintense on T2-weighted or fluid-sensitive MR sequences). MR imaging features of 40 patients with histologically proven soft tissue masses (27 benign and 13 malignant lesions) that were hypointense to muscle on T1-weighted and hyperintense on T2-weighted or fluid-sensitive MR sequences were analysed to see if a distinction could be made between benign and malignant lesions. There were 23 females and 17 males (mean age, 56 years; age range, 23-82 years). MR imaging features analysed for statistical significance included lesion size, lesion homogeneity, presence of lobulation, depth in relation to fascia and border definition. Clinical assessment included the age and sex of the patient and location of the lesion. Statistically significant MR imaging features favouring a diagnosis of a malignant lesion included larger average dimension of the mass (Por = 0.004), larger greatest dimension of the mass (Por = 0.028) and heterogeneity of the lesion on T1-weighted sequences (P = 0.017). The most statistically significant predictor of malignancy was the larger average dimension of the mass.
- Published
- 2006
22. Soft-tissue masses in the shoulder girdle: an imaging perspective
- Author
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Asif Saifuddin, Philip W. P. Bearcroft, and Srinivasan Harish
- Subjects
Shoulder ,medicine.medical_specialty ,Radiography ,Soft Tissue Neoplasms ,Computed tomography ,Imaging modalities ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Ultrasonography ,Neuroradiology ,medicine.diagnostic_test ,Cysts ,business.industry ,Soft tissue ,Magnetic resonance imaging ,General Medicine ,Anatomy ,Bursa, Synovial ,Magnetic Resonance Imaging ,medicine.anatomical_structure ,Shoulder region ,Shoulder girdle ,Radiology ,Tomography, X-Ray Computed ,business - Abstract
We discuss the radiological assessment of soft-tissue masses presenting in the shoulder girdle and emphasise the relative strengths and weaknesses of the different imaging modalities available. The appearances of the common benign and malignant soft-tissue tumours are presented together with conditions that present with specific imaging features around the shoulder region.
- Published
- 2006
23. Image-guided percutaneous biopsy of intramedullary lytic bone lesions: utility of aspirated blood clots
- Author
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Adrienne M. Flanagan, A. Saifuddin, Richard J. Hughes, and Srinivasan Harish
- Subjects
Adult ,medicine.medical_specialty ,Adolescent ,Bone and Bones ,law.invention ,Intramedullary rod ,Predictive Value of Tests ,law ,Biopsy ,Humans ,Medicine ,False Positive Reactions ,Radiology, Nuclear Medicine and imaging ,Child ,False Negative Reactions ,Aged ,Retrospective Studies ,Neuroradiology ,Aged, 80 and over ,medicine.diagnostic_test ,business.industry ,Biopsy, Needle ,Ultrasound ,Soft tissue ,Thrombosis ,Interventional radiology ,General Medicine ,Middle Aged ,Lytic cycle ,Child, Preschool ,Histopathology ,Radiology ,Bone Diseases ,business - Abstract
The diagnostic value of aspirating blood clots while performing percutaneous biopsy of intramedullary lytic bone lesions was assessed. This was a retrospective analysis of 400 patients with intramedullary lytic bone lesions who underwent image-guided needle biopsy. The nature of the specimens obtained was noted from the histopathology records. In 83 (20.8%) of the 400 patients, the specimen obtained was either blood clot only or essentially blood clot with only tiny fragments of bone or soft tissue. Lesional tissue was present on needle biopsy specimens in 65 (78.3%) of the 83 cases, while in 18 (21.7%) cases no lesional tissue was obtained. In 24 of the 83 cases, there was no surgical histological diagnosis available. In the 59 cases where surgical histological diagnosis was available for comparison, the diagnostic accuracy for needle biopsy was 73%. Percutaneous biopsy provided the diagnosis allowing appropriate further management in 62 cases, for an overall diagnostic yield of 75%. The results of our study show a sufficiently good diagnostic value in obtaining blood clots as to necessitate routine attempts at obtaining such material while performing percutaneous biopsy of intramedullary lytic bone lesions.
- Published
- 2006
24. MR imaging of autologous chondrocyte implantation of the knee
- Author
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Twr Briggs, A. Saifuddin, David Connell, J. A. Skinner, and Steven James
- Subjects
Cartilage, Articular ,musculoskeletal diseases ,medicine.medical_specialty ,Knee Joint ,Cell Transplantation ,Osteoarthritis ,Transplantation, Autologous ,Chondrocytes ,Postoperative Complications ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Autologous chondrocyte implantation ,Hyaline ,Neuroradiology ,medicine.diagnostic_test ,business.industry ,Cartilage ,Ultrasound ,Magnetic resonance imaging ,General Medicine ,Osteoarthritis, Knee ,medicine.disease ,Magnetic Resonance Imaging ,Surgery ,Transplantation ,medicine.anatomical_structure ,business ,Cartilage Diseases - Abstract
Autologous chondrocyte implantation (ACI) is a surgical technique that is increasingly being used in the treatment of full-thickness defects of articular cartilage in the knee. It involves the arthroscopic harvesting and in vitro culture of chondrocytes that are subsequently implanted into a previously identified chondral defect. The aim is to produce a repair tissue that closely resembles hyaline articular cartilage that gradually becomes incorporated, restoring joint congruity. Over the long term, it is hoped that this will prevent the progression of full-thickness articular cartilage defects to osteoarthritis. This article reviews the indications and operative procedure performed in ACI. Magnetic resonance imaging (MRI) sequences that provide optimal visualization of articular cartilage in the post-operative period are discussed. Normal appearances of ACI on MRI are presented along with common complications that are encountered with this technique.
- Published
- 2006
25. Imaging features of spinal osteoid osteoma with emphasis on MRI findings
- Author
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A. Saifuddin and Srinivasan Harish
- Subjects
Adult ,Male ,Osteoid osteoma ,medicine.medical_specialty ,Adolescent ,Radiography ,Osteoma, Osteoid ,Scoliosis ,Scintigraphy ,Sensitivity and Specificity ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Child ,Radionuclide Imaging ,Osteoma ,Retrospective Studies ,Neuroradiology ,Spinal Neoplasms ,medicine.diagnostic_test ,business.industry ,Reproducibility of Results ,Magnetic resonance imaging ,General Medicine ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Bone scintigraphy ,Female ,Radiology ,Tomography, X-Ray Computed ,business - Abstract
A retrospective evaluation of the imaging of 13 patients with a diagnosis of osteoid osteoma (OO) of the spine was undertaken. Available imaging included radiographs (n=10), computed tomography (CT) (n=13), bone scintigraphy (n=5) and magnetic resonance imaging (MRI) (n=13). MRI features evaluated were pattern of neural arch and vertebral body oedema and the presence of an identifiable nidus. MRI features were correlated with other available imaging. There were seven males and six females with an age range of 8-59 years. On radiographs, scoliosis was present in ten and a sclerotic pedicle in nine patients. Focal increased uptake on bone scintigraphy consistent with OO was seen in all five patients where scintigraphy was available. On CT, a nidus was identified in all patients and reactive sclerosis was seen in 12. MRI demonstrated the nidus in eight patients and unilateral neural arch oedema with anterior extension to involve the ipsilateral posterolateral vertebral body in 11. When MRI is performed in the evaluation of back pain, the presence of unilateral neural arch oedema extending to involve the posterolateral vertebral body raises the possibility of spinal OO and should prompt CT to confirm the presence of a nidus.
- Published
- 2005
26. MRI differentiation of low-grade from high-grade appendicular chondrosarcoma
- Author
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Asif Saifuddin, Hassan Douis, and Leanne Singh
- Subjects
musculoskeletal diseases ,Adult ,Male ,medicine.medical_specialty ,Adolescent ,Long bone ,Chondrosarcoma ,Bone Neoplasms ,Diagnosis, Differential ,Young Adult ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Femur ,Tibia ,Neuroradiology ,Aged ,Neoplasm Staging ,Retrospective Studies ,Aged, 80 and over ,medicine.diagnostic_test ,business.industry ,Soft tissue ,Reproducibility of Results ,Magnetic resonance imaging ,General Medicine ,Humerus ,Middle Aged ,musculoskeletal system ,Periostitis ,medicine.disease ,Magnetic Resonance Imaging ,medicine.anatomical_structure ,Female ,Radiology ,business ,Follow-Up Studies - Abstract
To identify magnetic resonance imaging (MRI) features which differentiate low-grade chondral lesions (atypical cartilaginous tumours/grade 1 chondrosarcoma) from high-grade chondrosarcomas (grade 2, grade 3 and dedifferentiated chondrosarcoma) of the major long bones. We identified all patients treated for central atypical cartilaginous tumours and central chondrosarcoma of major long bones (humerus, femur, tibia) over a 13-year period. The MRI studies were assessed for the following features: bone marrow oedema, soft tissue oedema, bone expansion, cortical thickening, cortical destruction, active periostitis, soft tissue mass and tumour length. The MRI-features were compared with the histopathological tumour grading using univariate, multivariate logistic regression and receiver operating characteristic curve (ROC) analyses. One hundred and seventy-nine tumours were included in this retrospective study. There were 28 atypical cartilaginous tumours, 79 grade 1 chondrosarcomas, 36 grade 2 chondrosarcomas, 13 grade 3 chondrosarcomas and 23 dedifferentiated chondrosarcomas. Multivariate analysis demonstrated that bone expansion (P = 0.001), active periostitis (P = 0.001), soft tissue mass (P
- Published
- 2013
27. The 3rd annual congress of the European society of skeletal radiology
- Author
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G. Garlaschi, N. Athanasou, M. Larciprete, J. Romero, F. Lomoschitz, J. E. Adams, E. Márton, J. S. Billiard, R. W. Kerslake, M. Braun, L. Molini, Ch. E. Willis, P. N. Kaposi, C. Reiners, A. D. Tasker, F. Landsiedl, Y. Itai, C. C. Glüer, Z. Turk, J. Kamnar, B. Dimitrijevic, K. Kiss, H. Mishima, C. R. Pal, R. Gröll, C. Tschauner, G. Zafiroski, L. De Clarck, K. Bártfai, F. Demsar, R. F. Capozza, J. Maighem, J. A. Larena, A. Vallcanera, R. Valls-Pascual, P. Bracke, R. Arkun, J. Malghem, H. K. Genant, K. W. Preidler, J. E. Foster, T. Rand, S. Hofmann, C. Inman, N. Gandolfo, T. Pirronti, B. E. Maldague, M. Keen, A. Alonso, M. Amoroso, J. A. Recondo, L. Romanini, S. M. Lemperle, A. Lienemann, J. Barovic, A. Cerase, P. Kern, J. M. Guinebretiere, A. M. De Schepper, G. Sallustio, D. Martinez, G. Missenard, L. Zugaro, G. Guglielmi, K. Lipscomp, H. Sittek, E. Papp, J. Scheidler, V. V. Potsybina, J. Brossmann, K. Bögl, S. Migliorini, I. Steingruber, Johan L. Bloem, S. J. Ostlere, A. Steinborn, A. Parrella, F. Ramon, J. Vogel, Ch. Rangger, R. Manetta, J. Freyschmidt, M. J. Breitenseher, T. Dévai, C. Kukla, J. Kramer, S. Usadel, J. Vandevenne, M. Østergaard, G. M. Giannatempo, P. Lang, M. Bertolotto, E. Krammel, H. Zollinger, M. F. Reiser, Z. Csókási, P. Tanji, G. J. S. Parkin, R. F. Bury, J. F. Møller, J. Eschberger, E. Steiner, J. H. Kühne, M. Baldt, G. J. Brand, G. Verhoek, T. Scarabino, M. Atanackovic, M. Zanetti, J. L. Ferrettiz, E. Makó, A. J. Phillps, W. Wright, R. Andresen, I. Beggs, T. Helbich, G. Vidoevski, T. R. Goodman, S. Duewell, R. E. Parrella, F. E. Lecouvet, S. Youssefzadeh, J. Esztergályos, G. Serafini, D. Sabah, G. Bacic, L. S. Steinbach, A. Baur, V. Jeftic, C. Gaebler, J. M. Muhaz-Vives, A. R. Cowen, E. Arana, W. A. Wallace, E. Bassetti, R. Schmitt, S. Majumdar, M. M. Ritter, S. Burnett, M. Niitsu, J. A. Larrea, G. A. Davies, A. Saifuddin, G. Kolousek, J. Taberner, J. Martin, H. Imhof, G. Honda, B. Rozman, A. Engel, A. Neuhold, M. Klarlund, F. Salvia, A. Barile, X. Catasuz-Capellades, T. Kákosy, S. Rühm, A. Mathur, E. M. Merkle, R. Passariello, E. Mindell, W. R. Obermann, C. Masciocchi, L. M. White, I. W. McCall, H. A. Vrooman, N. Prato, D. Banzer, G. Kolarz, H. C. Geisst, A. Memis, S. Faul, T. Akalin, D. Vanel, E. Elizagaray, F. Rossi, H. Czembirek, L. Poleksic, R. Girveni-Montilos, M. K. Benson, J. M. Alustiza, M. P. Recht, E. Salvador, S. Kreuzer, S. Behrendt, T. Monton, P. J. O'Connor, A. Heuck, R. Gambaretti, D. Szolar, R. Braunschweig, S. Jaovishidha, V. Jevtic, P. M. Rozing, M. Kos-Golja, J. Johnston, M. Martens, W. E. Masri, M. Posgay, A. DeSchepper, E. Sanchez, B. C. Vande Berg, C. Rodrigo, L. Satragno, M. Falchi, S. Radmer, H. Leitich, D. Mona, V. N. Cassar-Pullicino, A. Zerbi, S. Damiani, F. Kainberger, G. Argento, S. Grampp, H. J. Brambs, I. Stenzel, G. Kontaxis, J. Fernández, L. Duffek, D. Fleischmann, D. J. Sartoris, J. L. Garci, R. Maurizi Enrici, M. Mastantuono, C. Czerny, J. Villanua, G. Zografski, K. P. Adlassnig, M. Cammisa, M. Schulte, F. Priolo, A. Le Cesne, R. Cella, A. Heinze, N. De Stefano, B. Daenen, P. Mesaric, A. Safadin, T. Sorrentin, C. Pistitsch, F. Aparisi, Á. Mester, H. R. Dürr, D. J. Lintott, L. Marti-Bonmarti, J. Somerville, P. F. J. Tirman, M. Sparmann, W. Schneider, C. G. Peterfy, J. Sys, A. Gahleitner, S. Peerally, N. Trenti, S. Delucchi, G. M. DiLella, P. Schneider, J. Haller, I. Lorenzen, M. Uggowitzer, J. Michielsen, F. E. Lecoevet, E. E. Ustu, P. Mamdorff, G. Tabernero, T. Klestil, E. R. Valstar, F. Saez, G. Ranner, W. Zanolla, U. Salvolini, A. M. Davies, M. Hájek, M. Gabl, M. Stiskal, M. D. J. Harake, C. Cifrian, K. Sørensen, S. Bianchi, S. Hakim, A. W. Allen, J. L. Michaux, R. Zettl, E. Silvestri, M. De Maeseneer, V. Metz, W. Stevens, Pancras C.W. Hogendoorn, K. Herrmann, H. Daniaux, N. Obletter, L. Foderà Pierangeli, M. A. Sampson, S. Nehrer, Iain Watt, C. Jessel, J. Smolen, A. Stäbler, J. Liskutin, P. Emery, D. Kurková, M. DeMaeseneer, V. Herynek, D. Gazielly, M. Kolenc, J. D. Argent, S. Krämer, P. Schnarkowski, C. E. Neumaier, D. Trudell, M. V. Maffey, R. Bartl, R. Putz, J. Hodler, G. Seidl, K. J. Stevens, J. Griffiths, R. E. Holmes, B. Rottmann, Maartje J. A. Geirnaerdt, H. Bonél, J. Link, S. Forgacs, M. Nevitt, T. Helmberger, F. Menor, E. Llopis, M. Gstettner, A. Gneger, Joachim Kettenbach, I. Marti-Bonmati, J. Beltran, M. Takada, C. Montagnon, I. Martin, P. Dieppe, P. G. Reti, K. Karlinger, A. Kathrein, S. Trattnig, Ch. Kugler, H. Plenk, B. J. Preston, D. Resnick, W. W. Gibbon, M. Jergas, C. Faletti, R. M. Lloret, M. Steinborn, L. Németh, E. G. McNally, L. DeBeuckeleer, T. Ledermann, A. Chevrot, J. Raith, F. Nucci, C. Martinoli, P. L. Selby, W. Rosenau, R. C. Fowler, M. C. Barrera, J. White, A. Bray, D. McGonagle, Johan H. C. Reiber, and F. Fellner
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,medicine ,Radiology, Nuclear Medicine and imaging ,Medical physics ,Interventional radiology ,General Medicine ,Radiology ,business ,Skeletal radiology ,Neuroradiology - Published
- 1996
28. Lymphoma presenting as a musculoskeletal soft tissue mass: MRI findings in 24 cases
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S. Suresh, Paul O'Donnell, and Asif Saifuddin
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Adult ,Male ,Pathology ,medicine.medical_specialty ,Lymphoma ,Sensitivity and Specificity ,Lesion ,Diagnosis, Differential ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,False Positive Reactions ,Neuroradiology ,Aged ,Retrospective Studies ,Aged, 80 and over ,business.industry ,Soft tissue sarcoma ,Soft tissue ,Reproducibility of Results ,Sarcoma ,General Medicine ,Fascia ,Middle Aged ,medicine.disease ,Neurovascular bundle ,Magnetic Resonance Imaging ,medicine.anatomical_structure ,Female ,Radiology ,medicine.symptom ,Anatomical compartment ,business - Abstract
The purpose was to describe the MRI morphological features and signal intensity (SI) characteristics of 24 histologically proven cases of musculoskeletal soft tissue lymphoma presenting clinically as a suspected primary soft tissue sarcoma. This was a retrospective review of clinical notes and MRI studies of 24 patients with a histologically confirmed diagnosis of lymphoma. All patients presented to a specialist orthopaedic oncology unit with a suspected primary soft tissue sarcoma. Features assessed included lesion size and morphology, location, extension across anatomical compartments and signal intensity characteristics. The lesions were predominantly poorly defined with peritumoral oedema in ten cases. All tumours were of intermediate T1W SI, while 85% of lesions also showed intermediate T2W SI. Almost all cases that were located just deep to the fascia showed subcutaneous extension, while 50% had involvement of more than one muscle compartment. In 29% of cases, there was extension of tumour along the neurovascular bundle. Histo-pathologically, 23 lesions were non-Hodgkin's B-cell lymphoma. The MRI features of primary musculoskeletal soft tissue lymphoma include a mass with intermediate SI on T1W and T2W images, involvement of more than one anatomical compartment, subcutaneous extension and extension along the neurovascular bundle.
- Published
- 2007
29. The role of MR imaging in the diagnostic characterisation of appendicular bone tumours and tumour-like conditions
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Asif Saifuddin, A. M. Davies, Steven James, and Faisal Alyas
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Adult ,Male ,Pathology ,medicine.medical_specialty ,Bone Neoplasms ,Bone tumours ,Biopsy ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Neuroradiology ,medicine.diagnostic_test ,Tibia ,business.industry ,Cartilage ,Femoral Neoplasms ,Ultrasound ,Magnetic resonance imaging ,Interventional radiology ,General Medicine ,Humerus ,Middle Aged ,Magnetic Resonance Imaging ,medicine.anatomical_structure ,Primary bone ,Fibula ,Female ,Radiology ,Bone Diseases ,business - Abstract
MRI has an established role in the local staging of primary bone tumours. However, as the majority of tumours have non-specific appearances on MRI, the diagnosis is usually established on the basis of clinical history, plain film findings and biopsy. This article reviews the value of MRI in the further characterisation of appendicular bone tumours and tumour-like lesions, with particular reference to peri-lesional oedema, fluid-fluid levels, flow voids, fat signal, cartilage signal and dedifferentiation. These features are a useful adjunct for distinguishing between benign and malignant disease, pointing towards a more specific diagnosis, and guiding biopsy.
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- 2006
30. Non-communicating intramuscular ganglia
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I. Beggs, Asif Saifuddin, and D. Limb
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Adult ,Male ,medicine.medical_specialty ,Contrast Media ,Gadolinium ,Muscular Diseases ,Encapsulated Mass ,Medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Muscle, Skeletal ,Neuroradiology ,Retrospective Studies ,Ultrasonography ,medicine.diagnostic_test ,business.industry ,Ultrasound ,Biopsy, Needle ,Magnetic resonance imaging ,General Medicine ,Anatomy ,Middle Aged ,Image Enhancement ,Mr imaging ,Magnetic Resonance Imaging ,Synovial Cyst ,Female ,Radiology ,business - Abstract
Intramuscular ganglia are rare. Most of the previously reported cases were connected with an adjacent joint. We present the imaging findings in three patients who had intramuscular ganglia that were not connected with a joint. Magnetic resonance showed a septated, encapsulated mass that was iso- or hypointense to muscle on T1-weighted and hyperintense on T2-weighted images. A post-contrast T1-weighted scan in one patient showed minimal capsular enhancement. Ultrasound performed in one case showed an encapsulated, anechoic mass.
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- 1998
31. MRI differentiation of low-grade from high-grade appendicular chondrosarcoma
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Douis, Hassan, primary, Singh, Leanne, additional, and Saifuddin, Asif, additional
- Published
- 2013
- Full Text
- View/download PDF
32. Characterisation of intra-articular soft tissue tumours and tumour-like lesions
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Adams, Matthew E., primary and Saifuddin, Asif, additional
- Published
- 2006
- Full Text
- View/download PDF
33. Soft-tissue masses in the shoulder girdle: an imaging perspective
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Harish, Srinivasan, primary, Saifuddin, Asif, additional, and Bearcroft, Philip W. P., additional
- Published
- 2006
- Full Text
- View/download PDF
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