Search

Your search keyword '"Preda, Lorenzo"' showing total 16 results
Start Over Author "Preda, Lorenzo" Journal european radiology
16 results on '"Preda, Lorenzo"'

13. Metastatic and non-metastatic lymph nodes: quantification and different distribution of iodine uptake assessed by dual-energy CT.

Author

Rizzo, Stefania, Radice, Davide, Femia, Marco, De Marco, Paolo, Origgi, Daniela, Preda, Lorenzo, Barberis, Massimo, Vigorito, Raffaella, Mauri, Giovanni, Mauro, Alberto, and Bellomi, Massimo

Subjects
IODINE, LYMPH nodes, PATHOLOGICAL anatomy, COMPUTED tomography, ANALYSIS of variance, DIFFERENTIAL diagnosis, METASTASIS, RESEARCH bias, CONTRAST media, RETROSPECTIVE studies
Abstract

Objectives: To evaluate quantification of iodine uptake in metastatic and non-metastatic lymph nodes (LNs) by dual-energy CT (DECT) and to assess if the distribution of iodine within LNs at DECT correlates with the pathological structure.Methods: Ninety LNs from 37 patients (23 with lung and 14 with gynaecological malignancies) were retrospectively selected. Information of LNs sent for statistical analysis included Hounsfield units (HU) at different energy levels; decomposition material densities fat-iodine, iodine-fat, iodine-water, water-iodine. Statistical analysis included evaluation of interobserver variability, material decomposition densities and spatial HU distribution within LNs.Results: Interobserver agreement was excellent. There was a significant difference in iodine-fat and iodine-water decompositions comparing metastatic and non-metastatic LNs (p < 0.001); fat-iodine and water-iodine did not show significant differences. HU distribution showed a significant gradient from centre to periphery within non-metastatic LNs that was significant up to 20-30% from the centre, whereas metastatic LNs showed a more homogeneous distribution of HU, with no significant gradient.Conclusions: DECT demonstrated a lower iodine uptake in metastatic compared to non-metastatic LNs. Moreover, the internal iodine distribution showed an evident gradient of iodine distribution from centre to periphery in non-metastatic LNs, and a more homogeneous distribution within metastatic LNs, which corresponded to the pathological structure.Key Points: • This study demonstrated a lower iodine uptake in metastatic than non-metastatic LNs. • Internal distribution of HU was different between metastatic and non-metastatic lymph nodes. • The intranodal iodine distribution disclosed a remarkable correlation with the histological LN structure. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results