1. Diagnostic value of MRI-based 3D texture analysis for tissue characterisation and discrimination of low-grade chondrosarcoma from enchondroma: a pilot study
- Author
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Markus Schultheiss, Matthias Baumhauer, Kerstin Flosdorf, Meinrad Beer, Thomas F. E. Barth, Alexandra von Baer, Ambros J. Beer, Stefan Schmidt, Reinhard Meier, C Lisson, Regine Mayer-Steinacker, and Catharina S Lisson more...
- Subjects
Adult ,Male ,medicine.medical_specialty ,Imaging biomarker ,Chondrosarcoma ,Bone Neoplasms ,Pilot Projects ,Texture (geology) ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Imaging, Three-Dimensional ,Positron Emission Tomography Computed Tomography ,medicine ,Enchondroma ,Humans ,Radiology, Nuclear Medicine and imaging ,Entropy (energy dispersal) ,Aged ,Neoplasm Staging ,Retrospective Studies ,Aged, 80 and over ,Tomography, Emission-Computed, Single-Photon ,Receiver operating characteristic ,business.industry ,General Medicine ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,ROC Curve ,Skewness ,030220 oncology & carcinogenesis ,Kurtosis ,Female ,Radiology ,business ,Chondroma - Abstract
To explore the diagnostic value of MRI-based 3D texture analysis to identify texture features that can be used for discrimination of low-grade chondrosarcoma from enchondroma. Eleven patients with low-grade chondrosarcoma and 11 patients with enchondroma were retrospectively evaluated. Texture analysis was performed using mint Lesion: Kurtosis, entropy, skewness, mean of positive pixels (MPP) and uniformity of positive pixel distribution (UPP) were obtained in four MRI sequences and correlated with histopathology. The Mann-Whitney U-test and receiver operating characteristic (ROC) analysis were performed to identify most discriminative texture features. Sensitivity, specificity, accuracy and optimal cut-off values were calculated. Significant differences were found in four of 20 texture parameters with regard to the different MRI sequences (p more...
- Published
- 2016