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Introduction: The action mechanisms that explain how Mindfulness Based Interventions (MBIs) improve the well-being of people with mental disorders remain unclear (Alsubaie et al., 2017). This question leads us to ask how we measure mindfulness as a construct. Only two questionnaires are available nowadays in Spanish: the Five Facets Mindfulness Questionnaire (FFMQ) (Cebolla et al., 2012) and the Mindfulness Attention and Awareness Scale (MAAS) (Brown and Ryan, 2003). In the Spanish validation of the MAAS (Soler et al., 2012) the authors report a lack of sensibility to change that may render it inadequate to be used for the purpose of measuring the influence over mindfulness of a given intervention. Objectives: To test if a MBI (SocialMIND®) increases mindfulness, as measured by MAAS. Methods: A prospective single group clinical trial including participants with psychotic disorders was carried out. Mindfulness disposition was measured with the MAAS after 8 weeks of treatment. Results: 33 participants were included. MAAS scores did not increase after SocialMIND® (t=0.005, p=1). Conclusions: These results seem to support previous evidence which points towards the lack of sensibility to change of the MAAS (MacKillop et al., 2007; Soler et al., 2012). MAAS does not discriminate between non meditators and novice meditators. This is highly important in psychotic population because they have troubles acquiring habits, such as meditation. MAAS might be a valid instrument for studies where intense meditation practice is made, so a pre-post intervention change may be detected. More sensible instruments or new specific ones must be validated in Spanish. [ABSTRACT FROM AUTHOR]

Introduction: Cognitive impairment is usually found in people with Schizophrenia SpectrumDisorder (SDD) (Schaefer et al., 2013). Sustained attention is one of the most characteristic cognitive areas affected and has been largely studied for decades (Hoonakker et al., 2017). Sustained attention is defined as the ability to maintain attention on a given stimulus or task for a span of time (Parasuraman, 1984). Mindfulness is theorized to improve the attentional process. However, the effects of Mindfulness Based Interventions (MBIs) on cognition are still unclear (Lao & Meadows, 2017). Objectives: To test if a MBI (SocialMIND®) improves attentional performance in SDD patients Methods: A parallel-group, single-blind, randomized, controlled (SocialMIND® versus Psychoeducational Multicomponent Intervention [PMI]), clinical trial has been implemented. The participants received 16 weeks group therapy of SocialMIND® or PMI. Sustained attention was measured with the Continuous Performance Test (CPT-IP). Results: 23 participants were included. A better performance on CPT-IP was found in patients allocated to SocialMIND® (M=3.46, SD=0.73) compared to PMI (M=2.79, SD=1.18) after sixteen weeks of treatment (T=2.89, p=0.009, d=1.19). However, this improvement was only found in the 2-digit task. Conclusions: 3-digit and 4-digit tasks increase the difficulty of the test involving greater implication of other cognitive processes such as working memory. Taking this into account, it's possible that MBIs improves sustained attention but has no effects on working memory. [ABSTRACT FROM AUTHOR]

Introduction: Studies have associated students from Medicine and other healthcare degrees with high levels of stress and depression. This puts at risk both their mental health and the quality of physician-patient relationship. Mindfulness-Based Stress Reduction (MBSR) program has been shown to improve psychological wellbeing and to reduce rumination; however, it seems unclear if digital programs have the same effect. Objectives: To compare the effectiveness of a mindfulness smartphone app versus an adapted version of the MBSR program among healthcare students. Methods: A parallel-group, single-blind, randomised (1:1:1), controlled trial was designed. 140 students of Medicine, Nursing, Psychology and Nutrition were allocated to either the app program, the in-person program, or a waitlist. The assessment of depressive symptoms was included though the Beck Depression Inventory at baseline and post-intervention (8 weeks). Results: 86 participants completed BDI at both times and an intention-to-treat analysis was performed. Depressive levels changed from 7.21 (SD 6.08) to 4.07 (SD 4.44) in the app group, and from 7.11 (SD 6.62) to 5.26 (SD 5.21) in the in-person group. ANOVA test did not find a significant difference for depression among the three arms. Conclusions: Only a tendency to significance was found for both the app and the in-person program for the reduction of depressive symptoms. Most participants presented minimum levels of depression at baseline, so a floor effect might be considered as an explanation. Future studies are needed to determine the effect of mindfulnessbased programs on the depression levels of healthcare students. [ABSTRACT FROM AUTHOR]

Introduction: Insight disruption is a core characteristic of Schizophrenia Spectrum Disorder (SSD) (Moritz et al., 2017). Beck introduced the concept of "cognitive insight" as the capacity of the patient to distance oneself from and to reevaluate misguided beliefs and interpretations (Beck et al., 2004). This insight can bemeasured by the Beck Cognitive Insight Scale (BCIS). Mindfulness is defined as paying attention to the present moment, on purpose and non-judgmentally (Kabat-Zinn, 1994). Mindfulness meditation promotes an open orientation to one's mental events so Mindfulness Based Interventions (MBIs) might improve psychotic patients' cognitive insight. Objectives: To test if a mindfulness-based intervention (SocialMIND®) for patients with first-episode psychosis increases cognitive insight. Methods: A parallel-group, randomized, controlled (SocialMIND® versus psychoeducational multicomponent intervention [PMI]), clinical trial has been implemented. 23 participants received 16 weeks of group therapy. Cognitive insight was measured with the BCIS. Results: There were significant differences in BCIS scores in the Self-certainty subscale between PMI (M1=9,09, SD=3,83, M2=9.55, S.D2=3.24,) and SocialMIND® (M1=6,46, SD1=2,44, M2=5.38, SD2=2.66) after 16 weeks of treatment (t(22)=-2.2, p=0.04, d=0.88). Conclusions: This result is congruent with the theorical background of each intervention. PMI focuses on providing educational information about psychosis. This expert information might lead to the sensation of a better understanding of the pathology and may increase the sensation of certainty. Meanwhile, SocialMIND® approaches the psychotic experience and the way the patient's mind is working from an experiential and individual point of view. This might lead to a greater awareness of mental processes, reducing the certainty about mind contents. [ABSTRACT FROM AUTHOR]

Introduction: Mindfulness-based interventions are showing promising results for people with Schizophrenia Spectrum Disorders (SSD) (Goldberg et al., 2018), though their action mechanisms are yet to be clarified. Social cognition has drawn a great deal of attention in recent decades as people with psychosis tend to perform worse than healthy controls in socio-cognitive tasks (Green et al., 2015). A core component of social cognition is attributional style and people with psychosis tend to perceive more intentionality and hostility in other people's behaviors in negative and ambiguous situations than controls (Savla et al., 2012). Objectives: To explore the changes in hostility bias after Social-MIND® in a sample of people with SSD. Methods: SocialMIND® is a mindfulness-based social cognition training delivered over 9 months, the first two including 8 weekly sessions. 46 patients were included: 25 subjects completed a feasibility trial (Mediavilla et al., 2019a) while 21 subjects are currently enrolled in a Randomized Controlled Trial (Mediavilla et al., 2019b). Assessment included the Ambiguous Intentions Hostility Questionnaire (AIHQ). Results: 46 participants completed weekly sessions and assessment. Participants showed a significant improvement in hostility bias as measured by the AIHQ (p=0,018, d=0,38). Conclusions: SocialMIND® is among the few social cognition trainings to achieve an improvement in hostility bias in people with psychosis (Roberts et al., 2014). Given the role of social cognition in SSD as predictor and mediator of social functioning (Galderisi et al., 2018), future research lines should delve deeper into the action mechanisms and key active ingredients of social cognition trainings for people with psychosis. [ABSTRACT FROM AUTHOR]

Introduction: Impairment in different social cognition domains has been found across different phases of schizophrenia spectrum disorders. There is growing evidence showing that they are linked with worse functional outcomes, which raises the question whether they remain stable over time. To date, few studies have tried to establish a comparison between social cognition performance in early and chronic psychosis and mixed findings have arised Objectives: The aim of the current study is to compare social cognition performance between samples of early and chronic psychosis. Methods: Data from 81 patients: 53 chronic (>5y) psychotic patients and 28 early psychosis (<5y) was collected. Patients were assessed on different Social Cognition tasks: Reading the mind in the eyes test (RMET), Ambiguous Intentions Hostility Questionnaire (AIHQ) and Hinting Task Test (HT). Results: Compared with chronic SSD patients, Early Psychosis group had better performance on some social cognition tasks: HT, Mean Difference (MD): -1,593 CI 95% -2,551 to -0,634 p:0.02; and RMET MD: -3,142 CI95% -5.490 to -0,794 p:0.01. Although no differences were found on global AIHQ performance, Early Psychosis patients tended to display more aggression attributions (AIHQ-AB MD: -,24080 CI95% -,474 to -,007 p: 0,044), and Chronic SSD patients more hostility attributions (AIHQ-HB MD: 0,303 CI95% 0,002 to 0,603) Conclusions: Social Cognition decline in psychotic population is a largely unexplored field, although it can be an important factor explaining functional decline in patients not attending psychosocial treatments focusing on this field. Clinical significance of the results and limitations of the study are discussed. [ABSTRACT FROM AUTHOR]

Introduction: Oncohematological diseases were the fifth cancerrelated cause of mortality in 2017. Given the development of new therapeutics options, life expectancy and cronicity rates have increased. Quality of life in these patients has become a very important issue. QoL in this group is quite lower than in general population. Among this group, those who go throught HSCT have more complicated situations; HSCT may have a deep emotional impact. 25-36% of HSCT patients have psychopathological disturbances, anxiety and depression symptoms are the most common. Anxiety and depression prior transplantation are associated with slower recovery from transplantation. It is important to give an integrative support to patients and families, including psychological interventions. Mindfulness-Based Intervention is a good option, given the nature of the process which sorrounds HSCT. Potential stressors and uncontrollable and unpredictable characteristics of the procedure require stress management, acceptance, compassion, self-care and emotion regulation habilities; all of them are trained in MBI. Objectives: To describe group differences between those who get emotional support and emotion regulation-MBI prior HSCT, and those who do not, in terms of sociodemographic and clinical data. Methods: Retrospective, quasi-experimental study. We will study differences between both groups: age, gender, diagnosis, disease stage, type of transplantation (autologous or allogeneic), marital and employment status. Results: We will expect to find some predictors variables of who engages in psychological intervention and who does not, in order to find new approaches to attend needs of every singular patient. Conclusions: Caring emotional aspects of these patients could positively influence the course of disease, and help to increase QoL. [ABSTRACT FROM AUTHOR]

Introduction: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis, formally recognized in 2007, is more frequent than any other known paraneoplastic encephalitis. A 77.8% of patients are young female adults. In approximately 40% of the subjects, the disease is associated with an ovarian teratoma. The teratomaassociated cases are significantly more likely to present psychiatric symptoms than those without teratomas. Objectives: We report the case of a 37-year old female patient who was admitted in the Neurology ward after presenting neurological features in combination with symptoms of mood disorder, insomnia and aggressive behavior. We aim to review the clinical features that should lead us to suspect an anti-NMDAR encephalitis in a patient with psychiatric symptoms. Methods: A case reported is presented. A narrative review via scientific database (PubMed) was conducted. Results: Our patient had previously suffered a virus encephalitis. At the beginning, she presented a non-specific prodromal phase with headache and fever, as well as abnormal behavior. She was admitted at the Neurology ward for follow-up. Later on, appeared insomnia, agitation, disorganized thinking, manic symptoms and autonomic instability. Anti-NMDAR encephalitis was confirmed with the detection of antibodies against the GluN1 subunit of the NMDAR in the CSF of the patient and an ovarian teratoma was found and removed. Conclusions: When a patient without any psychiatric history presents a new-onset psychosis, especially in combination with dyskinesias, seizures, memory problems, decreased level of consciousness and/or catatonia, anti-NMDAR encephalitis should always be considered as a differential diagnosis. [ABSTRACT FROM AUTHOR]

Introduction: Serotonin síndrome (SS) is a potentially lifethreatening condition caused by excessive serotonergic activity in the nervous system. It is characterized by mental status changes, autonomic instability, and neuromuscular hyperactivity. In patients taking linezolid, an oxazolidinone antibiotic widely used for resistant nosocomial infections, along with seretoninergic antidepressants there is a documented risk for SS. Objectives: We report the case of a difficult-to-control asthma patient, diagnosed with MRSA pneumonia during a prolonged hospitalization for asthma exacerbation, concurrently taking an SNRI (venlafaxine). We aim to review the evidence about the mechanisms of seretonin toxicity when drugs in the MAOinhibitor class (like linezolid) are combined with proseretoninergic agents as well as the current clinical guidelines for the management of patients with concurrent antidepressant treatment requiring linezolid for a new resistant nosocomial infection. Methods: A case report is presented. A narrative review via scientific database (PubMed, Google scholar) was conducted. Results: While SS has not been described in clinical trials of linezolid, several cases have been reported after commercialization of this antibiotic, especially when used concurrently or within close temporal relation to a seretoninergic agent like SSRI/SNRI antidepressants. The mechanism of action is not fully understood. Conclusions: To our knowledge, there are not any guidelines for the adequate management of these cases, with current recommendations for use of linezolid and seretoninergic antidepressants based on risk-benefit personalized analyses. [ABSTRACT FROM AUTHOR]