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Your search keyword '"Kircher, T."' showing total 13 results
Start Over Author "Kircher, T." Journal european psychiatry
13 results on '"Kircher, T."'

8. Macroscopic probes of brain dysmaturation in (developmental) pathopsychology

Author

Martinot, J.L., primary, McGuire, P., additional, Frangou, S., additional, Kircher, T., additional, Paillère-Martinot, M.L., additional, Galinowski, A., additional, De Beaurepaire, R., additional, Artiges, E., additional, Bellivier, F., additional, Duchesnay, E., additional, Pentillä, J., additional, Plaze, M., additional, Mangin, J.F., additional, and Cachia, A., additional

Published
2008
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9. Automatic assessment of brain gyrification in patients

Author

Martinot, J.L., primary, McGuire, P., additional, Kircher, T., additional, Hubl, D., additional, Allen, P., additional, Paillere-Martinot, M.L., additional, Galinowski, A., additional, Bellivier, F., additional, Januel, D., additional, De Beaurepaire, R., additional, Plaze, M., additional, Artiges, E., additional, Mangin, J.F., additional, and Cachia, A., additional

Published
2007
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13. Effect of COMT val158met genotype on cognition and personality

Author

Sheldrick, A.J., Krug, A., Markov, V., Leube, D., Michel, T.M., Zerres, K., Eggermann, T., and Kircher, T.

Subjects
*GENETIC regulation, *GENETIC code, *PERSONALITY & cognition, *GENETIC polymorphisms, *DOPAMINE, *SCHIZOPHRENIA, *PREFRONTAL cortex, *TRANSFERASES
Abstract

Abstract: The gene encoding catechol-O-methyltransferase (COMT), an enzyme which regulates prefrontal cortex dopamine, contains a common functional single nucleotide polymorphism (val158met, rs4680G/A), which accounts for part of the interindividual variance in performance during working memory tasks and also predicts personality traits. We examined the relationship between the val158met polymorphism and cognitive function as well as personality traits in 522 healthy individuals (mean age: 24.75 years, SD=5.84, mean years of education: 15.59, SD=2.65). COMT val158met genotype was related in allele dosage fashion to performance in an executive function test, with the met/met carriers scoring highest. Subjects carrying the met/met genotype also scored higher in the disorganization domain of the SPQ-B personality inventory. Consistent with evidence from previous studies, higher dopamine availability of the met/met genotype enhances prefrontally mediated executive function in healthy individuals. Furthermore, we replicated findings from a recent study whereby the COMT genotype also predicts disorganized personality features. [Copyright &y& Elsevier]

Published
2008
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