1. Lymphocyte peripheral benzodiazepine receptor mRNA decreases in obsessive-compulsive disorder
- Author
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Carola Eva, Filippo Bogetto, A.M. Beoni, Paola Rocca, Giuseppe Maina, Patrizia Ferrero, and Luigi Ravizza
- Subjects
Adult ,Male ,Obsessive-Compulsive Disorder ,medicine.medical_specialty ,Transcription, Genetic ,medicine.drug_class ,Lymphocyte ,behavioral disciplines and activities ,Obsessive compulsive ,Internal medicine ,mental disorders ,Gene expression ,medicine ,Humans ,Pharmacology (medical) ,Lymphocytes ,RNA, Messenger ,Receptor ,Biological Psychiatry ,Pharmacology ,Analysis of Variance ,Messenger RNA ,Benzodiazepine ,business.industry ,Isoquinolines ,Receptors, GABA-A ,humanities ,Peripheral ,Psychiatry and Mental health ,medicine.anatomical_structure ,Endocrinology ,Neurology ,Immunology ,Female ,Neurology (clinical) ,Analysis of variance ,business - Abstract
The relative content of peripheral benzodiazepine receptor (pBR) mRNA was examined by reverse transcriptase-polymerase chain reaction in lymphocytes of obsessive-compulsive disorder (OCD) patients, according to their clinical course of illness. pBR mRNA significantly decreased only in chronic OCD patients (n=8) as compared to controls (n=10), whereas no significant changes were observed in episodic OCD patients (n=7). We suggest that modulation of pBR gene expression might delineate a clinical heterogeneity in OCD.
- Published
- 2000
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