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Start Over Author "A. Budde" Journal european neuropsychopharmacology
174 results on '"A. Budde"'

1. Contrasting genetic burden for bipolar disorder: Early onset versus late onset in an older adult bipolar disorder sample

Author

Montejo, Laura, Sole, Brisa, Fico, Giovanna, Kalman, Janos L., Budde, Monika, Heilbronner, Urs, Oliva, Vincenzo, De Prisco, Michele, Martin-Parra, Sara, Ruiz, Andrea, Martinez-Aran, Anabel, Adorjan, Kristina, Falkai, Peter, Heilbronner, Maria, Kohshour, Mojtaba Oraki, Reich-Erkelenz, Daniela, Schaupp, Sabrina K., Schulte, Eva C., Senner, Fanny, Vogl, Thomas, Anghelescu, Ion-George, Arolt, Volker, Baune, Bernhard T., Dannlowski, Udo, Dietrich, Detlef E., Fallgatter, Andreas J., Figge, Christian, Juckel, Georg, Konrad, Carsten, Reimer, Jens, Reininghaus, Eva Z., Schmauß, Max, Wiltfang, Jens, Zimmermann, Jörg, Vieta, Eduard, Papiol, Sergi, Schulze, Thomas G., and Torrent, Carla

Published
2025
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2. Efficient region-based test strategy uncovers genetic risk factors for functional outcome in bipolar disorder

Author

Budde, Monika, Friedrichs, Stefanie, Alliey-Rodriguez, Ney, Ament, Seth, Badner, Judith A., Berrettini, Wade H., Bloss, Cinnamon S., Byerley, William, Cichon, Sven, Comes, Ashley L., Coryell, William, Craig, David W., Degenhardt, Franziska, Edenberg, Howard J., Foroud, Tatiana, Forstner, Andreas J., Frank, Josef, Gershon, Elliot S., Goes, Fernando S., Greenwood, Tiffany A., Guo, Yiran, Hipolito, Maria, Hood, Leroy, Keating, Brendan J., Koller, Daniel L., Lawson, William B., Liu, Chunyu, Mahon, Pamela B., McInnis, Melvin G., McMahon, Francis J., Meier, Sandra M., Mühleisen, Thomas W., Murray, Sarah S., Nievergelt, Caroline M., Nurnberger, John I., Jr., Nwulia, Evaristus A., Potash, James B., Quarless, Danjuma, Rice, John, Roach, Jared C., Scheftner, William A., Schork, Nicholas J., Shekhtman, Tatyana, Shilling, Paul D., Smith, Erin N., Streit, Fabian, Strohmaier, Jana, Szelinger, Szabolcs, Treutlein, Jens, Witt, Stephanie H., Zandi, Peter P., Zhang, Peng, Zöllner, Sebastian, Bickeböller, Heike, Falkai, Peter G., Kelsoe, John R., Nöthen, Markus M., Rietschel, Marcella, Schulze, Thomas G., and Malzahn, Dörthe

Published
2019
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3. W81. GENETICS MEETS TRANSCRIPTOMICS: EXPRESSION AND SPLICING OUTLIER ANALYSIS IN WHOLE TRANSCRIPTOMES OF INDIVIDUALS WITH SCHIZOPHRENIA

Author

Schulte, Eva, primary, Yepez, Vicente A., additional, Degenhardt, Franziska, additional, Adorjan, Kristina, additional, Budde, Monika, additional, Kalman, Janos, additional, Papiol, Sergi, additional, Senner, Fanny, additional, Forstner, Andreas J., additional, Heilbronner, Urs, additional, Nöthen, Markus, additional, Falkai, Peter, additional, Gagneur, Julien, additional, and Schulze, Thomas G., additional

Published
2023
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6. CONTRIBUTION OF POLYGENIC SCORES FOR A “COMMON EXECUTIVE FUNCTION” FACTOR TO COGNITIVE PERFORMANCE IN THE PSYCOURSE STUDY

Author

Wendel, Bernadette, primary, Heilbronner, Maria, additional, Papiol, Sergi, additional, Adorjan, Kristina, additional, Budde, Monika, additional, Kalman, Janos L., additional, Kohshour, Mojtaba Oraki, additional, Schaupp, Sabrina K., additional, Schulte, Eva C., additional, Senner, Fanny, additional, Vogl, Thomas, additional, Falkai, Peter, additional, Schulze, Thomas G., additional, Bickeböller, Heike, additional, and Heilbronner, Urs, additional

Published
2022
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7. INVESTIGATING THE EFFECT OF MITOCHONDRIA-RELATED GENES’ VARIANTS AND THEIR GENETIC RISK BURDEN ON COGNITIVE PERFORMANCE IN THE PSYCOURSE STUDY

Author

Kohshour, Mojtaba Oraki, primary, Papiol, Sergi, additional, Schulte, Eva, additional, Heilbronner, Urs, additional, Budde, Monika, additional, Kalman, Janos, additional, Senner, Fanny, additional, Heilbronner, Maria, additional, Reich-Erkelenz, Daniela, additional, Schaupp, Sabrina K, additional, Thomas, Vogl, additional, Adorjan, Kristina, additional, Falkai, Peter, additional, and Schulze, Thomas G., additional

Published
2022
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8. T97. ANALYSIS OF MITOCHONDRIAL-RELATED GENES SUGGESTS THAT COA8 GENE IS ASSOCIATED WITH SHORT-TERM MEMORY IN THE PSYCOURSE STUDY

Author

Kohshour, Mojtaba Oraki, primary, Papiol, Sergi, additional, Schulte, Eva, additional, Heilbronner, Urs, additional, Budde, Monika, additional, Kalman, Janos, additional, Senner, Fanny, additional, Heilbronner, Maria, additional, Reich-Erkelenz, Daniela, additional, Schaupp, Sabrina K., additional, Thomas, Vogl, additional, Adorjan, Kristina, additional, Falkai, Peter, additional, and Schulze, Thomas G., additional

Published
2022
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9. HIGHER GENETIC BURDEN FOR BIPOLAR DISORDER IN EARLY ONSET BIPOLAR DISORDER (EOBD) PATIENTS IN AN OLDER ADULTS BIPOLAR DISORDER (OABD) SAMPLE

Author

Montejo, Laura, primary, Sole, Brisa, additional, Martinez-Aran, Anabel, additional, Vieta, Eduard, additional, Jimenez, Esther, additional, Sanchez-Moreno, Jose, additional, Budde, Monika, additional, Heilbronner, Urs, additional, Kalman, Janos, additional, Schulze, Thomas G., additional, Papiol, Sergi, additional, and Torrent, Carla, additional

Published
2022
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14. INVESTIGATING THE EFFECT OF MITOCHONDRIA-RELATED GENES’ VARIANTS AND THEIR GENETIC RISK BURDEN ON COGNITIVE PERFORMANCE IN THE PSYCOURSE STUDY

Author

Mojtaba Oraki Kohshour, Sergi Papiol, Eva Schulte, Urs Heilbronner, Monika Budde, Janos Kalman, Fanny Senner, Maria Heilbronner, Daniela Reich-Erkelenz, Sabrina K Schaupp, Vogl Thomas, Kristina Adorjan, Peter Falkai, and Thomas G. Schulze

Subjects
Pharmacology, Psychiatry and Mental health, Neurology, Pharmacology (medical), Neurology (clinical), Biological Psychiatry
Published
2022
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15. HIGHER GENETIC BURDEN FOR BIPOLAR DISORDER IN EARLY ONSET BIPOLAR DISORDER (EOBD) PATIENTS IN AN OLDER ADULTS BIPOLAR DISORDER (OABD) SAMPLE

Author

Laura Montejo, Brisa Sole, Anabel Martinez-Aran, Eduard Vieta, Esther Jimenez, Jose Sanchez-Moreno, Monika Budde, Urs Heilbronner, Janos Kalman, Thomas G. Schulze, Sergi Papiol, and Carla Torrent

Subjects
Pharmacology, Psychiatry and Mental health, Neurology, Pharmacology (medical), Neurology (clinical), Biological Psychiatry
Published
2022
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16. T97. ANALYSIS OF MITOCHONDRIAL-RELATED GENES SUGGESTS THAT COA8 GENE IS ASSOCIATED WITH SHORT-TERM MEMORY IN THE PSYCOURSE STUDY

Author

Mojtaba Oraki Kohshour, Sergi Papiol, Eva Schulte, Urs Heilbronner, Monika Budde, Janos Kalman, Fanny Senner, Maria Heilbronner, Daniela Reich-Erkelenz, Sabrina K. Schaupp, Vogl Thomas, Kristina Adorjan, Peter Falkai, and Thomas G. Schulze

Subjects
Pharmacology, Psychiatry and Mental health, Neurology, Pharmacology (medical), Neurology (clinical), Biological Psychiatry
Published
2022
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17. CONTRIBUTION OF POLYGENIC SCORES FOR A 'COMMON EXECUTIVE FUNCTION' FACTOR TO COGNITIVE PERFORMANCE IN THE PSYCOURSE STUDY

Author

Bernadette Wendel, Maria Heilbronner, Sergi Papiol, Kristina Adorjan, Monika Budde, Janos L. Kalman, Mojtaba Oraki Kohshour, Sabrina K. Schaupp, Eva C. Schulte, Fanny Senner, Thomas Vogl, Peter Falkai, Thomas G. Schulze, Heike Bickeböller, and Urs Heilbronner

Subjects
Pharmacology, Psychiatry and Mental health, Neurology, Pharmacology (medical), Neurology (clinical), Biological Psychiatry
Published
2022
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18. TH22. IDENTIFICATION OF IMMUNE-RELATED SERUM PROTEINS ASSOCIATED WITH GENETIC RISK OF BIPOLAR DISORDER

Author

Kohshour, Mojtaba Oraki, primary, Papiol, Sergi, additional, Just, David, additional, Kannaiyan, Nirmal Raman, additional, Budde, Monika, additional, Heilbronner, Urs, additional, Kalman, Janos, additional, Schulte, Eva, additional, Rietschel, Marcella, additional, Nöthen, Markus, additional, Rossner, Moritz, additional, Falkai, Peter, additional, Nilsson, Peter, additional, and Schulze, Thomas G., additional

Published
2021
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19. W39. EVALUATION OF THE ASSOCIATION BETWEEN SERUM PROTEINS AND NEUROCOGNITIVE PERFORMANCE IN BIPOLAR DISORDER AND SCHIZOPHRENIA PATIENTS

Author

Kohshour, Mojtaba Oraki, primary, Papiol, Sergi, additional, Just, David, additional, Kannaiyan, Nirmal Raman, additional, Budde, Monika, additional, Heilbronner, Urs, additional, Kalman, Janos, additional, Schulte, Eva, additional, Rietschel, Marcella, additional, Nöthen, Markus, additional, Rossner, Moritz, additional, Falkai, Peter, additional, Nilsson, Peter, additional, and Schulze, Thomas G., additional

Published
2021
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20. W39. EVALUATION OF THE ASSOCIATION BETWEEN SERUM PROTEINS AND NEUROCOGNITIVE PERFORMANCE IN BIPOLAR DISORDER AND SCHIZOPHRENIA PATIENTS

Author

Mojtaba Oraki Kohshour, Eva C. Schulte, Nirmal Kannaiyan, Thomas G. Schulze, Urs Heilbronner, Peter Falkai, Peter Nilsson, Monika Budde, Janos Kalman, David Just, Sergi Papiol, Moritz J. Rossner, Markus M. Nöthen, and Marcella Rietschel

Subjects
Pharmacology, Oncology, medicine.medical_specialty, business.industry, medicine.disease, Blood proteins, Psychiatry and Mental health, Neurology, Schizophrenia, Internal medicine, medicine, Pharmacology (medical), Neurology (clinical), Bipolar disorder, Association (psychology), business, Neurocognitive, Biological Psychiatry
Published
2021
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21. TH22. IDENTIFICATION OF IMMUNE-RELATED SERUM PROTEINS ASSOCIATED WITH GENETIC RISK OF BIPOLAR DISORDER

Author

Mojtaba Oraki Kohshour, Sergi Papiol, Urs Heilbronner, Moritz J. Rossner, Markus M. Nöthen, Peter Nilsson, Nirmal Kannaiyan, Marcella Rietschel, Eva C. Schulte, Peter Falkai, Thomas G. Schulze, David Just, Monika Budde, and Janos Kalman

Subjects
Pharmacology, business.industry, medicine.disease, Blood proteins, Psychiatry and Mental health, Immune system, Neurology, Immunology, Medicine, Pharmacology (medical), Identification (biology), Neurology (clinical), Bipolar disorder, Genetic risk, business, Biological Psychiatry
Published
2021
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24. S48DIFFERENTIAL CHRONOTYPE POLYGENIC LOAD IN PSYCHIATRIC DISORDERS

Author

Monika Budde, Kristina Adorjan, Janos Kalman, Till F. M. Andlauer, Ashley L. Lütticke, Sabrina K. Schaupp, Thomas G. Schulze, Fanny Senner, Urs Heilbronner, Peter Falkai, Tomoya Yoshida, Sergi Papiol, Farah Klöhn-Saghatolislam, Eva C. Schulte, and Katrin Gade

Subjects
Pharmacology, Psychiatry and Mental health, medicine.medical_specialty, Neurology, business.industry, medicine, Chronotype, Pharmacology (medical), Neurology (clinical), Psychiatry, business, Biological Psychiatry
Published
2019
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25. T72POLYGENIC BACKGROUND OF ADHERENCE BEHAVIOUR

Author

Katrin Gade, Tomoya Yoshida, Eva C. Schulte, Thomas G. Schulze, Kristina Adorjan, Sergi Papiol, Farah Klöhn-Saghatolislam, Peter Falkai, Ashley L. Lütticke, Sabrina K. Schaupp, Urs Heilbronner, Fanny Senner, Tadafumi Kato, Monika Budde, and Janos Kalman

Subjects
Pharmacology, Psychiatry and Mental health, Adherence behaviour, Neurology, business.industry, Medicine, Pharmacology (medical), Neurology (clinical), business, Biological Psychiatry, Clinical psychology
Published
2019
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26. S46A GENOME-WIDE ASSOCIATION STUDY OF THE LONGITUDINAL COURSE OF EXECUTIVE FUNCTIONS

Author

Urs Heilbronner, Kristina Adorjan, Franziska Degenhardt, Fanny Senner, Till F. M. Andlauer, Monika Budde, Heike Bickeböller, Ashley L. Comes, Janos Kalman, Katrin Gade, Sergi Papiol, Bernadette Wendel, Eva C. Schulte, and Thomas G. Schulze

Subjects
Pharmacology, Longitudinal Course, Psychiatry and Mental health, Neurology, Pharmacology (medical), Genome-wide association study, Neurology (clinical), Executive functions, Psychology, Biological Psychiatry, Clinical psychology
Published
2019
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27. T72POLYGENIC BACKGROUND OF ADHERENCE BEHAVIOUR

Author

Yoshida, Tomoya, primary, Senner, Fanny, additional, Klöhn-Saghatolislam, Farah, additional, Papiol, Sergi, additional, Adorjan, Kristina, additional, Budde, Monika, additional, Lütticke, Ashley L., additional, Gade, Katrin, additional, Heilbronner, Urs, additional, Kalman, Janos, additional, Schaupp, Sabrina, additional, Schulte, Eva, additional, Falkai, Peter, additional, Kato, Tadafumi, additional, and Schulze, Thomas G., additional

Published
2019
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28. 70 POLYGENIC BACKGROUND OF SUICIDAL BEHAVIOR

Author

Yoshida, Tomoya, primary, Papiol, Sergi, additional, Adorjan, Kristina, additional, Budde, Monika, additional, Lütticke, Ashley L., additional, Gade, Katrin, additional, Heilbronner, Urs, additional, Kalman, Janos, additional, Klöhn-Saghatolislam, Farahnaz, additional, Schaupp, Sabrina K., additional, Schulte, Eva C., additional, Senner, Fanny, additional, Falkai, Peter, additional, Kato, Tadafumi, additional, and Schulze, Thomas G., additional

Published
2019
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29. S46A GENOME-WIDE ASSOCIATION STUDY OF THE LONGITUDINAL COURSE OF EXECUTIVE FUNCTIONS

Author

Heilbronner, Urs, primary, Wendel, Bernadette, additional, Budde, Monika, additional, Gade, Katrin, additional, Adorjan, Kristina, additional, Kalman, Janos, additional, Senner, Fanny, additional, Andlauer, Till, additional, Comes, Ashley, additional, Schulte, Eva, additional, Papiol, Sergi, additional, Degenhardt, Franziska, additional, Bickeböller, Heike, additional, and Schulze, Thomas, additional

Published
2019
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30. S48DIFFERENTIAL CHRONOTYPE POLYGENIC LOAD IN PSYCHIATRIC DISORDERS

Author

Papiol, Sergi, primary, Yoshida, Tomoya, additional, Andlauer, Till F.M., additional, Adorjan, Kristina, additional, Budde, Monika, additional, Lütticke, Ashley L., additional, Gade, Katrin, additional, Heilbronner, Urs, additional, Kalman, Janos, additional, Klöhn-Saghatolislam, Farah, additional, Schaupp, Sabrina, additional, Schulte, Eva, additional, Senner, Fanny, additional, Falkai, Peter, additional, and Schulze, Thomas G., additional

Published
2019
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31. M44 COGNITIVE PERFORMANCE IN THE PSYCOURSE STUDY: THE AFFECTIVE-TO-PSYCHOTIC SPECTRUM AND ITS ASSOCIATION WITH POLYGENIC RISK SCORES FOR SEVERE MENTAL ILLNESSES

Author

Budde, Monika, primary, Schaupp, Sabrina K., additional, Comes, Ashley L., additional, Papiol, Sergi, additional, Yoshida, Tomoya, additional, Adorjan, Kristina, additional, Anderson-Schmidt, Heike, additional, Gade, Katrin, additional, Kalman, Janos L., additional, Senner, Fanny, additional, Rietschel, Marcella, additional, Nöthen, Markus, additional, Falkai, Peter, additional, Schulze, Thomas G., additional, and Heilbronner, Urs, additional

Published
2019
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32. T46THE GENETIC RELATIONSHIP BETWEEN EDUCATIONAL ATTAINMENT AND COGNITIVE PERFORMANCE IN MAJOR PSYCHIATRIC DISORDERS

Author

Lütticke, Ashley, primary, Senner, Fanny, additional, Budde, Monika, additional, Adorjan, Kristina, additional, Heilbronner, Urs, additional, Kalman, Janos, additional, Reich-Erkelenz, Daniela, additional, Klöhn-Saghatolislam, Farah, additional, Schaupp, Sabrina, additional, Schulte, Eva, additional, Falkai, Peter, additional, Rietschel, Marcella, additional, Nöthen, Markus, additional, Schulze, Thomas, additional, and Papiol, Sergi, additional

Published
2019
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33. 96 LIPIDOME ANALYSIS IN INDIVIDUALS WITH SCHIZOPHRENIA REVEALS CHARACTERISTIC PLASMA LIPID PROFILES

Author

Schulte, Eva, primary, Tkachev, Anna, additional, Adorjan, Kristina, additional, Anderson-Schmidt, Heike, additional, Budde, Monika, additional, Gade, Katrin, additional, Heilbronner, Urs, additional, Kalman, Janos, additional, Lutticke, Ashley, additional, Papiol, Sergi, additional, Senner, Fanny, additional, Falkai, Peter, additional, Khaitovich, Philipp, additional, and Schulze, Thomas, additional

Published
2019
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35. POLYGENIC BURDEN ANALYSIS OF LONGITUDINAL CLUSTERS OF PSYCHOPATHOLOGICAL FEATURES IN A CROSS-DIAGNOSTIC GROUP OF INDIVIDUALS WITH SEVERE MENTAL ILLNESS

Author

Monika Budde, Peter Falkai, Janos Kalman, Heike Anderson-Schmidt, Kristina Adorjan, Ivan Kondofersky, Fanny Aldinger, Thomas G. Schulze, Fabian J. Theis, Katrin Gade, Sergi Papiol, Till F. M. Andlauer, Eva C. Schulte, Urs Heilbronner, and Nikola S. Müller

Subjects
Pharmacology, Positive and Negative Syndrome Scale, business.industry, Global Assessment of Functioning, Schizoaffective disorder, medicine.disease, Young Mania Rating Scale, Psychiatry and Mental health, Neurology, Schizophrenia, Medicine, Pharmacology (medical), Bipolar disorder, Neurology (clinical), business, Biological Psychiatry, Clinical psychology, Psychopathology, Cohort study
Abstract

Background Bipolar disorder (BD), schizophrenia (SZ) and schizoaffective disorder (SZA) can be disabling disorders associated with severe psychiatric symptomatology. Individual psychopathological features often overlap between these diagnostic groups and their severity can vary widely. More severe psychopathological features are generally associated with a less favorable outcome. Further, all three diseases are common complex genetic disorders with a polygenic genetic architecture in the majority of cases. The inherent heterogeneity with regard to disease severity has posed a significant challenge to both the study of the underlying disease mechanism and the clinical management. Therefore, stratification of cases into more homogeneous subgroups across diagnoses using both longitudinal clusters derived from psychometric data and genetic information could provide a means to identify individuals with higher risk for severe illness, mandating earlier and intensified clinical intervention. Methods Individuals included herein partake in an ongoing multisite cohort study across Germany and Austria (www.kfo241.de; www.PsyCourse.de). Participants were characterized at 4 time points over an 18-months period using a comprehensive phenotyping battery. The subsample used here totals 198 participants (46.9±12.4 yrs; 46% female) with DSM-IV diagnoses of SZ, SZA or BD. Blood DNA samples were genotyped using Illumina’s Infinium PsychArray and imputed using the 1000 genomes. SZ-PRS were calculated using PLINK 1.07. Effect sizes and p-values were determined with the PGC2 SZ summary results as discovery sample. A set of 67 longitudinally measured variables derived from the Positive and Negative Syndrome Scale (PANSS), the Inventory of Depressive Symptoms (IDS) and the Young Mania Rating Scale (YMRS) entered the cluster analyses. Factor analysis for mixed data (FAMD) was applied to compute abstract data dimensions, subsequently used to derive the longitudinal trajectories which then served as inputs for a k-mean clustering for longitudinal data. Identified clusters were employed in a linear regression model as predictive variables for SZ-PRS at 11 thresholds. Results Computed by FAMD, the strongest loadings were observed for PANSS and IDS on the first dimension and for IDS on the second dimension. Two clusters of longitudinal trajectories were identified in these dimensions: (A) individuals with continuously low scores on both PANSS and IDS (70.7%) and (B) individuals with consistently high scores on both PANSS and IDS (29.3%). Clusters differed significantly with regard to Global Assessment of Functioning (GAF; higher in (A); FDR-adjusted p-value=2.23x10-10), while there were no significant differences regarding sex, age, diagnoses, center, age at onset, family history or duration of illness. Cluster membership was not significantly associated with the SZ-PRS in either cluster. Discussion Although the results are preliminary and have to be interpreted with caution, the approach of longitudinal clustering to identify cross-diagnostic homogeneous subgroups of individuals appears to be feasible. The fact that more severe psychopathological features were not associated with increased genetic risk burden will also be interesting to explore further.

Published
2019
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36. HIGH-THROUGHPUT ANTIBODY-BASED PROFILING OF SERUM IN SCHIZOPHRENIA AND BIPOLAR DISORDER PATIENTS: AN INTEGRATIVE GENOMICS-PROTEOMICS PILOT STUDY

Author

Monika Budde, Nirmal Kannaiyan, Heike Anderson-Schmidt, Moritz J. Rossner, Thomas G. Schulze, Sergi Papiol, Urs Heilbronner, Peter Nilsson, David Just, and Katrin Gade

Subjects
Oncology, medicine.medical_specialty, Human Protein Atlas, Proteomics, 03 medical and health sciences, symbols.namesake, 0302 clinical medicine, Internal medicine, Medicine, SNP, Pharmacology (medical), 1000 Genomes Project, Biological Psychiatry, Pharmacology, business.industry, Blood proteins, 030227 psychiatry, Psychiatry and Mental health, Bonferroni correction, Neurology, Cohort, symbols, Neurology (clinical), Personalized medicine, business, 030217 neurology & neurosurgery
Abstract

Background The identification of biological markers in the peripheral blood for the prediction of the individual clinical outcome has an enormous potential in the frame of personalized medicine. Previous studies have already tried to create predictive models for major psychiatric disorders based on serum protein profiles though with inconclusive results. This study leverages the rich repertoire of biosamples available in the KFO241/PsyCourse cohort to perform a high-throughput antibody-based serum protein profiling. The aim of this pilot study is to establish the feasibility of such an analysis in the serum of these patients. This study also capitalizes on the availability of genomic data to carry out an integrative (genomics/proteomics) profiling. Methods Serum samples of 113 Schizophrenia (SCZ) and 125 Bipolar Disorder (BD) patients belonging to the German KFO241/PsyCourse cohort (www.kfo241.de; www.PsyCourse.de) were included in this study. All biomaterials in this cohort (blood, serum, plasma, DNA, RNA), available at different time points given its longitudinal design, are part of a high-end biobank. The expression of a selected panel of ~100 serum proteins was determined using a set of 155 antibodies in a high-throughput antibody-based assay. This suspension bead array technology enables a multiplexed protein profiling and it leverages the information generated by the Human Protein Atlas (www.proteinatlas.org). Median fluorescent intensities were log-transformed / standardized for downstream analyses. DNA samples were genotyped (Infinium PsychArray) and underwent genotype imputation (1000 Genomes Phase 3 ref. panel). Polygenic Risk Scores (PRS) were calculated by summing up the weighted effect of each SNP contributing to the PRS to obtain an individual estimate of SCZ genetic risk burden. Age, sex and ancestry principal components were used as covariates. Results Multivariate profiles based on the whole panel of quantified proteins did not significantly discriminate between both diagnoses (SCZ and BD). Single-protein ANCOVA analyses revealed, after Bonferroni correction, significant differences in C4B, CFB, VWF, NRG1, BACE1 and other proteins between SCZ and BD samples. High-risk versus Low-risk patients (according to PRS thresholds 5E-8, 5E-2 and 1) did not show a differential level of expression of these proteins. Likewise, polygenic risk did not correlate with the serum level of any of the proteins. Suggestive serum pQTL loci were identified. Discussion Our results confirm the feasibility and potential of this approach using serum samples of psychiatric patients. The observed differences in protein levels between diagnoses warrant replication in independent samples controlling the effect of medication. These results lay the groundwork for large-scale analyses for the discovery of predictive biomarkers of course, outcome and treatment response in SCZ and BD. Such an approach, joining the longitudinal phenotyping and biosample availability at four different time points in the KFO241/PsyCourse cohort with state-of-the-art biomarker quantification methodologies, holds promise for the generation of clinically-relevant predictive models in complex psychiatric disorders.

Published
2019
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37. SU53A CROSS-DIAGNOSTIC GWAS OF LONGITUDINAL EXECUTIVE FUNCTION PROFILE SCORES

Author

Till F. M. Andlauer, Bernadette Wendel, Katrin Gade, Kristina Adorjan, Urs Heilbronner, Thomas G. Schulze, Monika Budde, Heike Bickeböller, Sergi Papiol, Janos Kalman, Eva C. Schulte, Fanny Senner, and Ashley L. Comes

Subjects
Pharmacology, Psychiatry and Mental health, Neurology, business.industry, Medicine, Pharmacology (medical), Genome-wide association study, Neurology (clinical), Function (mathematics), business, Biological Psychiatry, Clinical psychology
Published
2019
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38. RARE VARIANTS WITHIN LOCI HARBORING COMMON VARIANTS ASSOCIATED WITH BIPOLAR DISORDER AND SCHIZOPHRENIA: FURTHER ELUCIDATING THE GENETIC ARCHITECTURE OF SEVERE PSYCHIATRIC ILLNESS

Author

Susanne Bengesser, Dan Rujescu, Thomas G. Schulze, Eva C. Schulte, Sergi Papiol, Monika Budde, Urs Heilbronner, and Eva Z. Reininghaus

Subjects
Pharmacology, Genetics, Genome-wide association study, Biology, Heritability, medicine.disease, Genetic architecture, Psychiatry and Mental health, Neurology, Schizophrenia, medicine, Pharmacology (medical), Identification (biology), Neurology (clinical), Bipolar disorder, Exome, Biological Psychiatry, Exome sequencing
Abstract

Background Bipolar Disorder (BP) and Schizophrenia (SZ) are common and genetically complex disorders characterized by often severe and overlapping symptoms. Although GWAS have identified several common variants increasing disease risk, a major portion of the heritability of both diseases has yet to be explained and may lie hidden in a collection of low-frequency, rare and ultra rare variants (MAF Methods Whole exomes of 186 individuals with a DSM-IV diagnose of type I BP and 173 individuals with a DSM-IV diagnosis of SZ were sequenced. Variants with MAF Results Burden testing (CAST) will be used to test for an overrepresentation of variants with MAF Discussion Through a combined approach of whole exome analysis and targeted resequencing, we hope to identify rare or ultra rare variants within the known GWAS loci, increasing an individual's risk of BP and SZ, as have been shown to exist for several other common complex genetic diseases. The identification of such variants would not only complete the picture of the genetic architecture of both disorders but could also provide a means to further explore the underlying pathophysiology through the development of more efficient animal models.

Published
2019
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39. SU62THE ROLE OF ENVIRONMENTAL STRESS AND DNA METHYLATION IN THE LONGITUDINAL COURSE OF BIPOLAR DISORDER

Author

Ashley Comes, Kristina Adorjan, Till Andlauer, Monika Budde, Franziska Degenhardt, Andreas J. Forstner, Katrin Gade, Urs Heilbronner, Janos Kalman, Ivan Kondofersky, Sergi Papiol, Fanny Senner, Sugirthan Sivalingam, Peter Falkai, and Thomas Schulze

Subjects
Pharmacology, Psychiatry and Mental health, Neurology, Pharmacology (medical), Neurology (clinical), Biological Psychiatry
Published
2019
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41. M44 COGNITIVE PERFORMANCE IN THE PSYCOURSE STUDY: THE AFFECTIVE-TO-PSYCHOTIC SPECTRUM AND ITS ASSOCIATION WITH POLYGENIC RISK SCORES FOR SEVERE MENTAL ILLNESSES

Author

Kristina Adorjan, Tomoya Yoshida, Sergi Papiol, Sabrina K. Schaupp, Ashley L. Comes, Katrin Gade, Monika Budde, Fanny Senner, Janos Kalman, Marcella Rietschel, Markus M. Nöthen, Heike Anderson-Schmidt, Peter Falkai, Thomas G. Schulze, and Urs Heilbronner

Subjects
Pharmacology, Psychiatry and Mental health, Neurology, Pharmacology (medical), Polygenic risk score, Neurology (clinical), Effects of sleep deprivation on cognitive performance, Association (psychology), Psychology, Biological Psychiatry, Clinical psychology
Published
2019
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42. 96 LIPIDOME ANALYSIS IN INDIVIDUALS WITH SCHIZOPHRENIA REVEALS CHARACTERISTIC PLASMA LIPID PROFILES

Author

Fanny Senner, Eva C. Schulte, Urs Heilbronner, Ashley L. Lütticke, Philipp Khaitovich, Kristina Adorjan, Anna Tkachev, Katrin Gade, Sergi Papiol, Heike Anderson-Schmidt, Thomas G. Schulze, Peter Falkai, Monika Budde, and Janos Kalman

Subjects
Pharmacology, medicine.medical_specialty, business.industry, Schizophrenia (object-oriented programming), Lipidome, Psychiatry and Mental health, Endocrinology, Neurology, Internal medicine, Plasma lipids, medicine, Pharmacology (medical), Neurology (clinical), business, Biological Psychiatry
Published
2019
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43. T46THE GENETIC RELATIONSHIP BETWEEN EDUCATIONAL ATTAINMENT AND COGNITIVE PERFORMANCE IN MAJOR PSYCHIATRIC DISORDERS

Author

Markus M. Nöthen, Sergi Papiol, Farah Klöhn-Saghatolislam, Eva C. Schulte, Monika Budde, Ashley L. Lütticke, Janos Kalman, Daniela Reich-Erkelenz, Kristina Adorjan, Marcella Rietschel, Thomas G. Schulze, Peter Falkai, Urs Heilbronner, Sabrina K. Schaupp, and Fanny Senner

Subjects
Pharmacology, Psychiatry and Mental health, Neurology, Pharmacology (medical), Neurology (clinical), Effects of sleep deprivation on cognitive performance, Psychology, Biological Psychiatry, Educational attainment, Clinical psychology
Published
2019
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44. COMMON GENETIC VARIANTS ASSOCIATED WITH PERSONALITY DIMENSIONS IN THE HEIDELBERG COHORT STUDY OF THE ELDERLY (HeiDE): AN UPDATE

Author

Heilbronner, Urs, primary, Andlauer, Till, additional, Papiol, Sergi, additional, Budde, Monika, additional, Strohmaier, Jana, additional, Streit, Fabian, additional, Frank, Josef, additional, Amelang, Manfred, additional, Stürmer, Til, additional, Muller-Myhsok, Bertram, additional, Rietschel, Marcella, additional, and Schulze, Thomas G., additional

Published
2019
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45. SU53A CROSS-DIAGNOSTIC GWAS OF LONGITUDINAL EXECUTIVE FUNCTION PROFILE SCORES

Author

Heilbronner, Urs, primary, Wendel, Bernadette, additional, Budde, Monika, additional, Gade, Katrin, additional, Adorjan, Kristina, additional, Kalman, Janos, additional, Senner, Fanny, additional, Andlauer, Till, additional, Comes, Ashley, additional, Schulte, Eva, additional, Papiol, Sergi, additional, Bickeböller, Heike, additional, and Schulze, Thomas, additional

Published
2019
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46. POLYGENIC BURDEN ANALYSIS OF LONGITUDINAL CLUSTERS OF PSYCHOPATHOLOGICAL FEATURES IN A CROSS-DIAGNOSTIC GROUP OF INDIVIDUALS WITH SEVERE MENTAL ILLNESS

Author

Schulte, Eva, primary, Kondofersky, Ivan, additional, Budde, Monika, additional, Adorjan, Kristina, additional, Aldinger, Fanny, additional, Anderson-Schmidt, Heike, additional, Andlauer, Till F.M., additional, Gade, Katrin, additional, Heilbronner, Urs, additional, Kalman, Janos, additional, Papiol, Sergi, additional, Theis, Fabian J., additional, Falkai, Peter, additional, Müller, Nikola, additional, and Schulze, Thomas G., additional

Published
2019
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47. SA125POLYGENIC BURDEN ANALYSIS OF LONGITUDINAL CLUSTERS OF PSYCHOPATHOLOGICAL FEATURES IN A CROSS-DIAGNOSTIC GROUP OF INDIVIDUALS WITH SEVERE MENTAL ILLNESS

Author

Schulte, Eva, primary, Kondofersky, Ivan, additional, Budde, Monika, additional, Adorjan, Kristina, additional, Aldinger, Fanny, additional, Anderson-Schmidt, Heike, additional, Gade, Katrin, additional, Heilbronner, Urs, additional, Kalman, Janos, additional, Papiol, Sergi, additional, Theis, Fabian J., additional, Falkai, Peter, additional, Müller, Nikola, additional, and Schulze, Thomas G., additional

Published
2019
Full Text
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