1. Brain Natriuretic Peptide upon Admission as a Biological Marker of Short-Term Mortality after Intracerebral Hemorrhage
- Author
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Kazumi Kimura, yoshino goya, Yusuke Ohya, Junya Aoki, Jyunichi Uemura, Kensaku Shibazaki, Naoki Saji, Katsunori Isa, and Kenichiro Sakai
- Subjects
Male ,Intracerebral hemorrhage ,medicine.medical_specialty ,business.industry ,Short term mortality ,Enzyme-Linked Immunosorbent Assay ,Middle Aged ,Prognosis ,Brain natriuretic peptide ,medicine.disease ,Neurology ,Internal medicine ,Natriuretic Peptide, Brain ,medicine ,Cardiology ,Humans ,Female ,Neurology (clinical) ,business ,Biomarkers ,hormones, hormone substitutes, and hormone antagonists ,Aged ,Cerebral Hemorrhage - Abstract
Background and Purpose: The purpose of the present study was to test the hypothesis that plasma brain natriuretic peptide (BNP) is associated with short-term mortality after intracerebral hemorrhage (ICH). Methods: We prospectively enrolled 271 patients (median age 72 years; 109 females) who were admitted within 24 h of ICH onset between April 2007 and July 2011 and in whom plasma BNP levels were measured upon admission. The patients were assigned to two groups according to survival within 1 month of ICH. Factors associated with mortality were determined by multivariate logistic regression analysis. Results: Within 1 month of ICH, 48 (17.7%) of the 271 enrolled patients died. The median (interquartile range) level of plasma BNP was significantly higher in the group of non-survivors than in the group of survivors [102.5 (48.7-205.0) vs. 32.4 (17.3-85.0) pg/ml; p < 0.001]. A cutoff BNP level of 60.0 pg/ml could predict death within 1 month of ICH. Multivariate logistic regression analysis showed that a plasma BNP of >60.0 pg/ml (OR 4.7; 95% CI 1.43-15.63; p = 0.011) was independently associated with mortality within 1 month after ICH. Conclusions: A high BNP level upon admission is associated with mortality within 1 month after ICH.
- Published
- 2014