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Start Over Author "E J Thompson" Journal european neurology
4 results on '"E J Thompson"'

1. No Evidence for Production of Intrathecal Immunoglobulin G against Acinetobacter or Pseudomonas in Multiple Sclerosis

Author

E J Thompson, C. Wilson, Chapman, S Namnyak, Gavin Giovannoni, and LE Hughes

Subjects
biology, Pseudomonas aeruginosa, Multiple sclerosis, medicine.disease_cause, medicine.disease, Immunoglobulin E, Immunoglobulin G, Myelin basic protein, Molecular mimicry, Neurology, Immunology, biology.protein, medicine, Neurology (clinical), Antibody, Pathogen
Abstract

The production of oligoclonal, polyspecific immunoglobulin G is characteristic of multiple sclerosis (MS), yet no pathogen has been identified as an infectious agent. Recent studies have proposed Acinetobactercalcoaceticus and Pseudomonas aeruginosa as candidate organisms, on the basis of a sequence homology between a bacterial enzyme and bovine myelin basic protein. To investigate this, we looked for specific, high-affinity immunoglobulin G against these pathogensin paired serum and cerebrospinal fluid from MS patients compared to other neurological diseases. We found no greater incidence of high-affinity antibodies against the organisms studied in MS vs. other neurological diseases, and so conclude that A. calcoaceticus and P. aeruginosa are unlikely to be implicated in the pathogenesis of MS.

Published
2004

2. Lack of Serum Oligoclonal Antibody Responses to Chlamydophila pneumoniae in Multiple Sclerosis

Author

AJ Church, E J Thompson, M.D. Chapman, J.C. Hartley, S.J. Furrows, Paul M. Candler, Gavin Giovannoni, and G.L. Ridgeway

Subjects
Pathology, medicine.medical_specialty, biology, Multiple sclerosis, medicine.disease_cause, biology.organism_classification, medicine.disease, Blot, Molecular mimicry, Cerebrospinal fluid, Neurology, Chlamydophila pneumoniae, Chlamydiales, Immunology, medicine, biology.protein, Chlamydiaceae, Neurology (clinical), Antibody
Abstract

Chlamydophila pneumoniae has been proposed as an aetiological agent in MS via a mechanism involving molecular mimicry. We undertook to investigate whether the presence of CSF oligoclonal IgG OCB or oligoclonal bands correlated with serum IgG raised against C. pneumoniae. Paired serum and CSF of 19 MS patients and 27 control patients with other neurological diseases were studied by IEF and Western blotting. Only 1 of 19 MS patients had serum antibodies against C. pneumoniae compared with 2 of the 26 control patients. This was not significant, leading us to conclude that this study does not support the theory of an association between C. pneumoniae and MS.

Published
2005

3. Lack of serum oligoclonal antibody responses to Chlamydophila pneumoniae in multiple sclerosis

Author

M D, Chapman, J C, Hartley, S J, Furrows, G L, Ridgeway, E J, Thompson, A J, Church, P M, Candler, and G, Giovannoni

Subjects
Multiple Sclerosis, Blotting, Western, Oligoclonal Bands, Animals, Humans, Chlamydophila pneumoniae, Isoelectric Focusing, Chlamydophila Infections
Abstract

Chlamydophila pneumoniae has been proposed as an aetiological agent in MS via a mechanism involving molecular mimicry. We undertook to investigate whether the presence of CSF oligoclonal IgG OCB or oligoclonal bands correlated with serum IgG raised against C. pneumoniae. Paired serum and CSF of 19 MS patients and 27 control patients with other neurological diseases were studied by IEF and Western blotting. Only 1 of 19 MS patients had serum antibodies against C. pneumoniae compared with 2 of the 26 control patients. This was not significant, leading us to conclude that this study does not support the theory of an association between C. pneumoniae and MS.

Published
2004

4. Immunological time-course of gadolinium-enhancing MRI lesions in patients with multiple sclerosis

Author

N.C. Silver, E J Thompson, Catriona D. Good, DH Miller, and Gavin Giovannoni

Subjects
Adult, Male, Pathology, medicine.medical_specialty, Multiple Sclerosis, Time Factors, Gadolinium, chemistry.chemical_element, Neopterin, Central nervous system disease, Disease activity, chemistry.chemical_compound, Interferon-gamma, Adrenal Cortex Hormones, medicine, Secondary Prevention, Humans, In patient, Poor correlation, business.industry, Multiple sclerosis, Macrophages, Brain, medicine.disease, Magnetic Resonance Imaging, Neurology, chemistry, Creatinine, Time course, Disease Progression, Female, Neurology (clinical), business, Biomarkers
Abstract

In multiple sclerosis (MS) gadolinium (Gd)-enhanced MRI activity correlates weakly with immunological markers of disease activity. We, therefore, tested the hypothesis that the poor correlation could be partly explained by the temporal profile of Gd enhancement. We measured urinary neopterin:creatinine ratios (neopt.:creat.urine) in 5 patients with active MS undergoing weekly Gd-enhanced MRI studies of the brain. The neopt.:creat.urine associated with new Gd-enhancing lesions (geometric neopt.: creat.urine = 413 μmol/mol (range = 207–521) vs. 250 μmol/mol (range = 132–492), p = 0.03]. Pro-inflammatory immunological markers, which are probably produced early on in the life cycle of an active MS lesion, should preferably be correlated with newly enhancing lesions (

Published
2000

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