1. Clinicopathological features and treatment outcome of oesophageal gastrointestinal stromal tumour (GIST)
- Author
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Yvonne Schrage, Astrid W. Oosten, Alessandro Gronchi, Sheima Farag, Peter Hohenberger, Neeltje Steeghs, Hans Gelderblom, Mahmoud Mohammadi, Ingrid M.E. Desar, An K.L. Reyners, Patrick Schöffski, Piotr Rutkowski, J.W. van Sandick, Nikolaos Vassos, Esther Bastiaannet, Nikki S. IJzerman, Robin L. Jones, Marco Baia, Javier Martin-Broto, Medical Oncology, Targeted Gynaecologic Oncology (TARGON), and Guided Treatment in Optimal Selected Cancer Patients (GUTS)
- Subjects
Male ,PROGNOSIS ,Esophageal Neoplasms ,Survival ,Anastomotic Leak ,LEIOMYOMAS ,Gastroenterology ,Postoperative Complications ,0302 clinical medicine ,Neoplasm Metastasis ,Treatment outcome ,RISK ,medicine.diagnostic_test ,GiST ,Margins of Excision ,General Medicine ,Middle Aged ,Neoadjuvant Therapy ,Progression-Free Survival ,Tumor Burden ,Europe ,Fine-needle aspiration ,Oncology ,Chemotherapy, Adjuvant ,030220 oncology & carcinogenesis ,Imatinib Mesylate ,Female ,030211 gastroenterology & hepatology ,Esophagoscopy ,Rare cancers Radboud Institute for Health Sciences [Radboudumc 9] ,medicine.medical_specialty ,Stromal cell ,RESECTION ,Gastrointestinal Stromal Tumors ,Biopsy, Fine-Needle ,Enucleation ,Antineoplastic Agents ,Disease-Free Survival ,CLASSIFICATION ,03 medical and health sciences ,Median follow-up ,Internal medicine ,Biopsy ,Mitotic Index ,medicine ,Adjuvant therapy ,Humans ,Aged ,Retrospective Studies ,Gastrointestinal stromal tumours ,business.industry ,ADENOCARCINOMA ,Plastic Surgery Procedures ,Esophagectomy ,Oesophagus ,PATHOLOGY ,Localized disease ,Surgery ,business - Abstract
Contains fulltext : 235268.pdf (Publisher’s version ) (Open Access) BACKGROUND: Oesophageal gastrointestinal stromal tumours (GISTs) account for ≤1% of all GISTs. Consequently, evidence to guide clinical decision-making is limited. METHODS: Clinicopathological features and outcomes in patients with primary oesophageal GIST from seven European countries were collected retrospectively. RESULTS: Eighty-three patients were identified, and median follow up was 55.0 months. At diagnosis, 59.0% had localized disease, 25.3% locally advanced and 13.3% synchronous metastasis. A biopsy (Fine Needle aspiration n = 29, histological biopsy n = 31) was performed in 60 (72.3%) patients. The mitotic count was low (5/5hpf) mitotic count were associated with worse disease free survival. CONCLUSION: Based on the current study, enucleation can be recommended for oesophageal GIST smaller than 4 cm, while oesophagectomy should be preserved for larger tumours. Patients with larger tumours (>4 cm) and/or high mitotic count should be treated with adjuvant therapy.
- Published
- 2021