1. Quality of life following urinary diversion: Orthotopic ileal neobladder versus ileal conduit. A multicentre study among long-term, female bladder cancer survivors
- Author
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Mauro Niero, Marco Racioppi, Carolina D'Elia, Paolo Verze, Sergio Serni, Giovanni Cacciamani, Davide De Marchi, Walter Artibani, Omar Saleh, Cristina Lonardi, Alchiede Simonato, Vincenzo Mirone, Renato Talamini, Stefano Ciciliato, Laura Toffoli, Ciro Imbimbo, Maria Angela Cerruto, Francesco Visalli, Mauro Gacci, Salvatore Siracusano, Antonio Benito Porcaro, Vincenzo De Marco, Massimo Iafrate, Pierfrancesco Bassi, Siracusano, S., D'Elia, C., Cerruto, M. A., Gacci, M., Ciciliato, S., Simonato, A., Porcaro, A., De Marco, V., Talamini, R., Toffoli, L., Saleh, O., Serni, S., Visalli, F., Niero, M., Lonardi, C., Imbimbo, C., Verze, P., Mirone, V., Racioppi, M., Iafrate, M., Cacciamani, G., De Marchi, D., Bassi, P., Artibani, W., Siracusano, Salvatore, D'Elia, Carolina, Cerruto, Maria Angela, Gacci, Mauro, Ciciliato, Stefano, Simonato, Alchiede, Porcaro, Antonio, De Marco, Vincenzo, Talamini, Renato, Toffoli, Laura, Saleh, Omar, Serni, Sergio, Visalli, Francesco, Niero, Mauro, Lonardi, Cristina, Imbimbo, Ciro, Verze, Paolo, Mirone, Vincenzo, Racioppi, Marco, Iafrate, Massimo, Cacciamani, Giovanni, De Marchi, Davide, Bassi, Pierfrancesco, and Artibani, Walter
- Subjects
Bladder cancer ,Ileal conduit ,Orthotopic neobladder ,Quality of life ,Radical cystectomy ,Women ,Time Factors ,medicine.medical_treatment ,030232 urology & nephrology ,Urinary Diversion ,Adult ,Aged ,Aged, 80 and over ,Cancer Survivors ,Cross-Sectional Studies ,Female ,Follow-Up Studies ,Humans ,Ileum ,Italy ,Middle Aged ,Surveys and Questionnaires ,Survival Rate ,Urinary Bladder Neoplasms ,Quality of Life ,Urinary Reservoirs, Continent ,Surgery ,Oncology ,0302 clinical medicine ,80 and over ,Surveys and Questionnaire ,Stage (cooking) ,Settore MED/24 - UROLOGIA ,General Medicine ,humanities ,030220 oncology & carcinogenesis ,Urinary Bladder Neoplasm ,Cancer Survivor ,Urinary Reservoirs ,Human ,medicine.medical_specialty ,Time Factor ,Follow-Up Studie ,Cystectomy ,03 medical and health sciences ,Internal medicine ,medicine ,Pathological ,Cross-Sectional Studie ,business.industry ,Urinary diversion ,Cancer ,medicine.disease ,Radiation therapy ,Continent ,business - Abstract
Introduction Women undergoing radical cystectomy (RC) followed by urinary diversion (UD) for bladder cancer experience a substantial reduction in health-related quality of life (HRQOL). At present, studies comparing long-term QOL outcomes for different UD methods, needed to inform evidence-based choices of bladder reconstruction for female patients, are sparse. Our objective was to compare two common UD methods in terms of their HRQOL outcomes in women. Materials and methods We retrospectively analysed HRQOL in 73 consecutive female bladder cancer patients having undergone orthotopic ileal neobladder (IONB, N = 24) or ileal conduit (IC, N = 49) following RC between 2007 and 2013 in six Italian academic urological centres. Patients had no evidence of tumour recurrence and were actively followed up. Validated Italian versions of the European Organisation for Research and Treatment of Cancer (EORTC) generic (QLQ-C30) and bladder-cancer-specific (QLQ-BLM30) questionnaires were used to evaluate HRQOL. Results Patients in the IONB group were significantly younger than those in the IC group (median age: 67 and 73 years, respectively, p = 0.02). Barring that, the two groups did not present statistically significant differences in median length of follow-up (43 vs 54 months), pathological stage, grading of the neoplasm, or adjuvant chemo - or radiotherapy. No significant differences in QOL were found between the groups, with the exception of financial difficulties, affecting IONB patients significantly more than IC patients (mean score on a scale of 0–100: 33.3 ± 29.5 vs 18.4 ± 19.3, respectively; p = 0.05). Conclusion Financial difficulties was the only HRQOL item to differ between the two UD groups.
- Published
- 2019