1. Atrial natriuretic factor inhibits norepinephrine release in an adrenergic clonal cell line (PC12)
- Author
-
J. G. Drewett, Richard S. Ziegler, Gary R. Marchand, and George J Trachte
- Subjects
medicine.medical_specialty ,Sympathetic nervous system ,Sympathetic Nervous System ,Adrenal Gland Neoplasms ,Adrenergic ,Pheochromocytoma ,Peptide hormone ,Neurotransmission ,Biology ,Norepinephrine (medication) ,chemistry.chemical_compound ,Norepinephrine ,Internal medicine ,otorhinolaryngologic diseases ,medicine ,Tumor Cells, Cultured ,Animals ,Neurotransmitter ,Pharmacology ,musculoskeletal system ,Rats ,Nerve growth factor ,Endocrinology ,medicine.anatomical_structure ,chemistry ,Peripheral nervous system ,embryonic structures ,cardiovascular system ,Carbachol ,hormones, hormone substitutes, and hormone antagonists ,Atrial Natriuretic Factor ,medicine.drug - Abstract
Evidence for a presynaptic neuromodulatory effect of atrial natriuretic factor (ANF) has been obtained in rat adrenal pheochromocytoma cells (PC12), a clonal line that differentiates into adrenergic neuron-like cells when treated with nerve growth factor. ANF had no effect on basal norepinephrine (NE) release. In contrast, ANF markedly and significantly inhibited carbachol-induced NE release in a concentration-dependent manner. This result is consistent with the hypothesis that ANF may be an inhibitory neuromodulator.
- Published
- 1988