1. Neurotensin participates in self-stimulation of the medial prefrontal cortex in the rat
- Author
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José A. Sáez, Raimundo Sabater, and J.M.R. Ferrer
- Subjects
Male ,Central nervous system ,Prefrontal Cortex ,Neuropeptide ,Stimulation ,Xenopus Proteins ,Rats, Sprague-Dawley ,chemistry.chemical_compound ,Self Stimulation ,Neurochemical ,medicine ,Animals ,Prefrontal cortex ,Neurotensin ,Pharmacology ,Dose-Response Relationship, Drug ,business.industry ,Electrodes, Implanted ,Rats ,medicine.anatomical_structure ,chemistry ,Cerebral cortex ,Microinjections ,Peptides ,business ,Oligopeptides ,Neuroscience - Abstract
The effects of intracerebral microinjections of neurotensin and xenopsin on self-stimulation of the medial prefrontal cortex of the rat were studied. Unilateral microinjections into the medial prefrontal cortex of neurotensin at doses of 0.625, 1.25, 2.5, 5 and 10 nmol produced a dose-related decrease of self-stimulation in the ipsilateral medial prefrontal cortex. Self-stimulation of the contralateral medial prefrontal contex, used as control, was not affected by the microinjections. Similar results were found with the neurotension-like octapeptide, xenopsin. Unilateral microinjections of xenoposin into the medial prefrontal cortex, at doses of 1.8, 3.6, 7.2 and 14.4 nmol produced a dose-related decrease of self-stimulation of the ipsilateral medial prefrontal cortex. Self-stimulation of the contralateral medial prefrontal cortex was not affected. These results suggest that neurotensin is part of the neurochemical substrate of self-stimulation in this cortical area.
- Published
- 1993
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