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Your search keyword '"Magalhães, Pedro"' showing total 15 results
Start Over "Magalhães, Pedro" Journal european journal of pharmacology
15 results on '"Magalhães, Pedro"'

2. Differential effects of β-methylphenylethylamine and octopamine on contractile parameters of the rat gastrointestinal tract

Author

de Oliveira, Daniel Maia Nogueira, primary, Oliveira-Silva, Carlos Alberto, additional, Pinheiro, Camila Gadelha, additional, de Carvalho, Emanuella Feitosa, additional, Gadelha, Kalinne Kelly Lima, additional, Lima-Silva, Karine, additional, Cavalcante, Ana Karolina Martins, additional, Belém, Mônica de Oliveira, additional, Paula, Suliana Mesquita, additional, dos Santos, Armênio Aguiar, additional, and Magalhães, Pedro Jorge Caldas, additional

Published
2021
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5. 1-Nitro-2-phenylethane, the main constituent of the essential oil of Aniba canelilla, elicits a vago-vagal bradycardiac and depressor reflex in normotensive rats

Author

de Siqueira, Rodrigo José Bezerra, Macedo, Francisco Igor Bulcão, Interaminense, Leylliane de Fátima Leal, Duarte, Gloria Pinto, Magalhães, Pedro Jorge Caldas, Brito, Teresinha Silva, da Silva, Joyce Kelly Rosário, Maia, José Guilherme Soares, Sousa, Pergentino José da Cunha, Leal-Cardoso, José Henrique, and Lahlou, Saad

Published
2010
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7. Soluble guanylate cyclase stimulator, trans-4-methoxy-β-nitrostyrene, has a beneficial effect in monocrotaline-induced pulmonary arterial hypertension in rats

Author

Gonzaga-Costa, Karoline, primary, Vasconcelos-Silva, Alfredo Augusto, additional, Rodrigues-Silva, Matyelle Jussára, additional, Rebouça, Conceição da Silva Martins, additional, Duarte, Glória Pinto, additional, Borges, Rosivaldo Santos, additional, Magalhães, Pedro Jorge Caldas, additional, and Lahlou, Saad, additional

Published
2021
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15. Linalool blocks excitability in peripheral nerves and voltage-dependent Na+ current in dissociated dorsal root ganglia neurons

Author

Leal-Cardoso, José Henrique, da Silva-Alves, Kerly Shamyra, Ferreira-da-Silva, Francisco Walber, dos Santos-Nascimento, Tiago, Joca, Humberto Cavalcante, de Macedo, Flávio Henrique Pequeno, de Albuquerque-Neto, Pedro Militão, Magalhães, Pedro Jorge Caldas, Lahlou, Saad, Cruz, Jader Santos, and Barbosa, Roseli

Subjects
*TERPENES, *GANGLIA, *SOMATIC sensation, *PERIPHERAL nervous system, *SODIUM, *PATCH-clamp techniques (Electrophysiology), *SCIATIC nerve, *NEURAL physiology
Abstract

Abstract: Linalool is a terpene that occurs as a major constituent of essential oils of many plants of widespread distribution. It possesses several biological and pharmacological activities, including depressant effects on the central nervous system and olfactory receptors. The present study investigated whether linalool affects the excitability of peripheral components of the somatic sensory system. We used sciatic nerve and preparations of intact and dissociated neurons of dorsal root ganglion for extracellular, intracellular and patch-clamp recordings. Linalool concentration-dependently (0.3–2.0mM) and reversibly blocked the excitability of the sciatic nerve. It inhibited peak-to-peak amplitude of the compound action potential (IC50 was 0.78±0.04mM). At 0.8mM, it reversibly increased rheobase and chronaxy (from 3.2±0.1V and 52.4±4.1μs to 4.2±0.3V and 71.2±5.5μs (n=5), respectively) and inhibited with greater pharmacological potency the amplitude of the compound action potential components corresponding to axons with slower velocity of conduction. In a similar concentration range (0.1–6mM), linalool concentration-dependently and reversibly blocked the generation of action potentials of intact dorsal root ganglion neurons without alteration of resting membrane potential and input resistance, and inhibited the voltage-gated Na+ current of dissociated dorsal root ganglion neurons. In conclusion, we demonstrated that linalool acts on the somatic sensory system with local anesthetic properties, since it blocked the action potential by acting on voltage-dependent Na+ channels. This finding is important in showing the potential usefulness of linalool as a pharmacotherapeutic agent. [ABSTRACT FROM AUTHOR]

Published
2010
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