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Your search keyword '"Pagán, Oné R."' showing total 1 results
Start Over Author "Pagán, Oné R." Topic withdrawal Journal european journal of pharmacology
1 results on '"Pagán, Oné R."'

1. Parthenolide prevents the expression of cocaine-induced withdrawal behavior in planarians

Author

Rowlands, Amanda L. and Pagán, Oné R.

Subjects
*SESQUITERPENE lactones, *PLANARIA, *WORMS, *COCAINE
Abstract

Abstract: We recently reported that parthenolide and related sesquiterpene lactones are able to prevent and reverse behavioral responses in planarian worms induced by acute cocaine exposure. Previous reports indicate that when planarians are chronically exposed to µM concentrations of cocaine, they display stereotypical withdrawal-like behaviors when the cocaine is removed. Here we report that parthenolide prevents this cocaine-induced expression of planarian withdrawal-like behaviors. [Copyright &y& Elsevier]

Published
2008
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