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Your search keyword '"Clarke, Matthew L."' showing total 1 results
Start Over Author "Clarke, Matthew L." Topic boronic acids Journal european journal of organic chemistry Publisher wiley-blackwell
1 results on '"Clarke, Matthew L."'

1. Phospholane‐Phosphite Ligands for Rh Catalyzed Enantioselective Conjugate Addition: Unusually Reactive Catalysts for Challenging Couplings.

Author

Gilbert, Sophie H., Fuentes, José A., Cordes, David B., Slawin, Alexandra M. Z., and Clarke, Matthew L.

Subjects
CONJUGATE addition reactions, RHODIUM catalysts, BORONIC acids, CATALYSTS, LIGANDS (Chemistry), ARYLATION, RHODIUM
Abstract

The use of Rh catalysts derived from a phospholane‐phosphite ligand were found to be more productive than the classic rhodium/BINAP system in enantioselective conjugate additions. These catalysts enable the use of lower amounts of aryl boronic acid in an asymmetric arylation reaction that required an impractical excess of nucleophile. This catalyst was also found to enable the coupling of a poorly reactive Michael acceptor, N‐CBz‐2‐3‐dehydro‐4‐piperidone, or the coupling of poorly reactive 2‐furyl boronic acids at ambient or near temperatures. [ABSTRACT FROM AUTHOR]

Published
2020
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