Search

Your search keyword '"Isamu Shiina"' showing total 2 results
Start Over "Isamu Shiina" Journal european journal of organic chemistry Publisher wiley
2 results on '"Isamu Shiina"'

1. Cover Feature: Total Synthesis of the Antitumor Depsipeptide FE399 and Its S‐Benzyl Derivative: A Macrolactamization Approach (Eur. J. Org. Chem. 32/2020)

Author

Isamu Shiina, Takayuki Tonoi, Ryo Kawahara, Takehiko Inohana, Miyuki Ikeda, Teruyuki Sato, and Takatsugu Murata

Subjects
Depsipeptide, chemistry.chemical_compound, Feature (computer vision), Chemistry, Stereochemistry, Organic Chemistry, Total synthesis, Cover (algebra), Physical and Theoretical Chemistry, Derivative (chemistry)
Published
2020
Full Text
View/download PDF

2. Kinetic Resolution of Racemic Carboxylic Acids Using Achiral Alcohols by the Promotion of Benzoic Anhydrides and Tetramisole Derivatives: Production of Chiral Nonsteroidal Anti-Inflammatory Drugs and Their Esters

Author

Isamu Shiina, Yu-suke Onda, and Kenya Nakata

Subjects
inorganic chemicals, Nonsteroidal, medicine.drug_class, Chemistry, organic chemicals, Organic Chemistry, Anti-inflammatory, Benzoic anhydride, Kinetic resolution, Catalysis, chemistry.chemical_compound, Transacylation, Reagent, medicine, Organic chemistry, Methanol, Physical and Theoretical Chemistry
Abstract

A variety of optically active carboxylic esters were produced by kinetic resolution of racemic carboxylic acids by using achiral alcohols, benzoic anhydrides, and Birman's tetramisole-type catalysts. Bis(α-naphthyl)methanol is a very effective reagent for producing the corresponding esters with high ee values in the presence of 4-methoxybenzoic anhydride (PMBA) as the coupling reagent by promotion of benzotetramisole derivatives (BTM, α-Np-BTM, and β-Np-BTM). This protocol directly provides chiral carboxylic esters from free carboxylic acids and achiral alcohols by utilizing a transacylation process to generate the mixed anhydrides from the acid components with benzoic anhydride derivatives in the presence of chiral catalysts.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

Published
2008
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results