1. "Mummy, my eyelids are heavy": A case series of juvenile myasthenia gravis.
- Author
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Krishna L, Abdul Jalil NF, Lott PW, Singh S, and Choo MM
- Subjects
- Autoantibodies blood, Blepharoptosis drug therapy, Blepharoptosis genetics, Child, Preschool, Cholinesterase Inhibitors therapeutic use, Diseases in Twins drug therapy, Diseases in Twins genetics, Drug Therapy, Combination, Female, Glucocorticoids therapeutic use, Humans, Infant, Myasthenia Gravis drug therapy, Myasthenia Gravis genetics, Prednisolone therapeutic use, Pyridostigmine Bromide therapeutic use, Receptors, Cholinergic immunology, Blepharoptosis diagnosis, Diseases in Twins diagnosis, Myasthenia Gravis diagnosis, Twins, Monozygotic
- Abstract
Purpose: To report three cases of juvenile myasthenia gravis aged between 18 and 24 months with ocular symptoms as their first presentation., Method: A case series., Results: We present a case series of juvenile myasthenia gravis in a tertiary centre in Malaysia. Two of the three cases consist of a pair of twins who presented with ptosis of bilateral eyes; the first twin presented 4 months later than the second twin. These two cases were positive for anti-acetylcholine receptor antibodies and had generalized myasthenia gravis, whereas the other case was negative for receptor antibodies and was purely ocular myasthenia gravis., Conclusion: Juvenile myasthenia gravis is relatively rare in toddlers. Early diagnosis and commencement of treatment is important to slow the progression of the disease and avoiding life-threatening events.
- Published
- 2021
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