1. A comprehensive assessment of outcomes in pregnancies conceived by in vitro fertilization/intracytoplasmic sperm injection
- Author
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Wen, Shi Wu, Leader, Arthur, White, Ruth Rennicks, Léveillé, Marie-Claude, Wilkie, Valerie, Zhou, Jia, and Walker, Mark C.
- Subjects
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HUMAN in vitro fertilization , *CONGENITAL heart disease , *OBESITY , *PREGNANCY complications , *HUMAN artificial insemination , *HEALTH outcome assessment - Abstract
Abstract: Objective: To assess the association between in vitro fertilization (IVF) with or without intracytoplasmic sperm injection (ICSI) and adverse birth outcomes. Study design: Retrospective cohort study involved IVF/ICSI patients who were treated in the Ottawa Fertility Centre from 1996 to 2005 with a viable pregnancy (>20 weeks of gestation) and mothers who conceived naturally. Results: Eleven of the 1044 infants conceived with IVF/ICSI (1.1%) and 7 of the 1910 naturally conceived infants (0.4%) had congenital heart defects (P <0.01). Five of the 138 infants (3.6%) born to mothers with a body mass index>30 and conceived by IVF/ICSI had congenital heart defects, compared with none in the 240 infants born to mothers with a body mass index>30 and conceived naturally (P <0.01). Conclusion: Infants conceived with use of IVF/ICSI have three times as high a risk of a congenital heart defect as naturally conceived infants. [Copyright &y& Elsevier]
- Published
- 2010
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