1. Treatment of COVID-19 in pregnant women: a systematic review and meta-analysis
- Author
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Steven Giesbers, Edwina Goh, Tania Kew, John Allotey, Vanessa Brizuela, Edna Kara, Heinke Kunst, Mercedes Bonet, Shakila Thangaratinam, Shaunak Chatterjee, Andrea Gae, Elena Stallings, Magnus Yap, Jameela Sheikh, Heidi Lawson, Dyuti Coomar, Anushka Dixit, Dengyi Zhou, Rishab Balaji, Megan Littmoden, Yasmin King, Luke Debenham, Anna Clavé Llavall, Kehkashan Ansari, Gurimaan Sandhu, Adeolu Banjoko, Helen Fraser, Tanisha Rajah, Anoushka Ramkumar, Alya Khashaba, Shruit Attarde, Kate Walker, Jim Thornton, Madelon van Wely, Elizabeth van Leeuwen, Elena Kostova, Asma Khalil, Simon Tiberi, Nathalie Broutet, Caron Rahn Kim, Anna Thorson, Olufemi T. Oladapo, Javier Zamora, and Lynne Mofenson
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,Population ,Review Article ,neonatal ,systematic review ,medicine ,Humans ,Caesarean section ,Prospective Studies ,Prospective cohort study ,education ,Retrospective Studies ,education.field_of_study ,Pregnancy ,treatment ,business.industry ,Obstetrics ,Cesarean Section ,SARS-CoV-2 ,Infant, Newborn ,Pregnancy Outcome ,Obstetrics and Gynecology ,COVID-19 ,Retrospective cohort study ,medicine.disease ,meta-analysis ,Systematic review ,Reproductive Medicine ,Meta-analysis ,Premature Birth ,Maternal death ,Female ,Pregnant Women ,pregnancy ,business - Abstract
OBJECTIVE: Clinical trials evaluating pharmacological and non-pharmacological treatment of COVID-19, either excluded pregnant women or included very few women. Unlike the numerous systematic reviews on prevalence, symptoms and adverse outcomes of COVID-19 in pregnancy, there are very few on the effects of treatment on maternal and neonatal outcomes in pregnancy. We undertook a systematic review of all published and unpublished studies on the effects of pharmacological and non-pharmacological interventions for COVID-19 on maternal and neonatal pregnancy outcomes. DATA SOURCES: We performed a systematic literature search of the following databases: Medline, Embase, Cochrane database, WHO (World Health Organization) COVID-19 database, China National Knowledge Infrastructure (CNKI), and Wanfang databases from 1 December 2019 to 1 December 2020. STUDY ELIGIBILITY CRITERIA: Studies were only included if they involved pregnant or postnatal women who were exposed to pregnancy specific interventions like the mode of delivery and type of anaesthesia, pharmacological or non-pharmacological interventions. STUDY APPRAISAL AND SYNTHESIS METHODS: We first screened the titles and abstracts of studies and then assessed the full text of the selected studies in detail for eligibility. Data on study design, population, type of screening for COVID-19, country, hospital, country status (high or low and middle income), treatment given (mode of delivery, type of anaesthesia, type of pharmacological and non-pharmacological treatment was extracted. The pre-defined maternal outcomes we collected were mode of delivery (vaginal or by caesarean section), severe or critical COVID-19 (as defined by the authors), symptomatic COVID-19, maternal death, maternal hospital admission, ICU admission, mechanical ventilation, ECMO and maternal pneumonia. The pre-defined neonatal outcomes we extracted were preterm birth (
- Published
- 2021