1. Resistant maltodextrin or fructooligosaccharides promotes GLP-1 production in male rats fed a high-fat and high-sucrose diet, and partially reduces energy intake and adiposity
- Author
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Hiroshi Hara, Tohru Hira, Ryoya Suto, Sumiko Kanahori, and Yuka Kishimoto
- Subjects
Male ,0301 basic medicine ,Sucrose ,Oligosaccharides ,Appetite ,Medicine (miscellaneous) ,Adipose tissue ,Rats, Sprague-Dawley ,chemistry.chemical_compound ,0302 clinical medicine ,Glucagon-Like Peptide 1 ,Fructooligosaccharides ,Ingestion ,Food science ,Intestinal Mucosa ,Cecum ,Adiposity ,media_common ,chemistry.chemical_classification ,Nutrition and Dietetics ,integumentary system ,Chemistry ,Organ Size ,High-fat and high-sucrose diet ,Maltodextrin ,Glucagon-like peptide-1 ,Gastrointestinal Contents ,Digestion ,Resistant maltodextrin ,medicine.medical_specialty ,media_common.quotation_subject ,030209 endocrinology & metabolism ,Intra-Abdominal Fat ,03 medical and health sciences ,Polysaccharides ,Internal medicine ,Appetite Depressants ,medicine ,Animals ,Obesity ,Glycemic ,030109 nutrition & dietetics ,Fatty Acids, Volatile ,Prebiotics ,Endocrinology ,Gene Expression Regulation ,Diet, Western ,Fermentation ,Propionate ,Dysbiosis ,Energy Intake - Abstract
Purpose Increasing secretion and production of glucagon-like peptide-1 (GLP-1) by continuous ingestion of certain food components has been expected to prevent glucose intolerance and obesity. In this study, we examined whether a physiological dose (5% weight in diet) of digestion-resistant maltodextrin (RMD) has a GLP-1-promoting effect in rats fed a high-fat and high-sucrose (HFS) diet. Methods Rats were fed a control diet or the HFS (30% fat, 40% sucrose wt/wt) diet supplemented with 5% RMD or fructooligosaccharides (FOS) for 8 weeks or for 8 days in separated experiments. Glucose tolerance, energy intake, plasma and tissue GLP-1 concentrations, and cecal short-chain fatty acids concentrations were assessed. Results After 4 weeks of feeding, HFS-fed rats had significantly higher glycemic response to oral glucose than control rats, but rats fed HFS?+?RMD/FOS did not (approx. 50% reduction vs HFS rats). HFS?+?RMD/FOS-fed rats had higher GLP-1 responses (~twofold) to oral glucose, than control rats. After 8 weeks, visceral adipose tissue weight was significantly higher in HFS-fed rats than control rats, while HFS?+?RMD/FOS rats had a trend of reduced gain (~50%) of the tissue weight. GLP-1 contents and luminal propionate concentrations in the large intestine increased (>twofold) by adding RMD/FOS to HFS. Eight days feeding of RMD/FOS-supplemented diets reduced energy intake (~10%) and enhanced cecal GLP-1 production (~twofold), compared to HFS diet. Conclusions The physiological dose of a prebiotic fiber promptly (within 8 days) promotes GLP-1 production in rats fed an obesogenic diet, which would help to prevent excess energy intake and fat accumulation.
- Published
- 2017