1. Maternal diet quality and associations with plasma lipid profiles and pregnancy-related cardiometabolic health.
- Author
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van der Pligt, Paige F., Kuswara, Konsita, McNaughton, Sarah A., Abbott, Gavin, Islam, Sheikh Mohammed Shariful, Huynh, Kevin, Meikle, Peter J., Mousa, Aya, and Ellery, Stacey J.
- Subjects
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CARDIOVASCULAR disease prevention , *MOTHERS , *CARDIOVASCULAR diseases risk factors , *BLOOD pressure , *WEIGHT gain in pregnancy , *TRIGLYCERIDES , *BIOMARKERS , *MULTIPLE regression analysis , *NUTRITIONAL requirements , *DIET , *GESTATIONAL age , *BLOOD collection , *RISK assessment , *COMPARATIVE studies , *DESCRIPTIVE statistics , *HEALTH behavior , *RESEARCH funding , *FOOD quality , *GESTATIONAL diabetes , *BODY mass index , *LIPIDS , *PREGNANCY - Abstract
Purpose: To assess the relationship of early pregnancy maternal diet quality (DQ) with maternal plasma lipids and indicators of cardiometabolic health, including blood pressure (BP), gestational diabetes mellitus (GDM) and gestational weight gain (GWG). Methods: Women (n = 215) aged 18–40 years with singleton pregnancies were recruited at 10–20 weeks gestation. Diet quality was assessed by the Dietary Guideline Index, calculated at early ([mean ± SD]) (15 ± 3 weeks) and late (35 ± 2 weeks) pregnancy. Lipidomic analysis was performed, and 698 species across 37 lipid classes were measured from plasma blood samples collected at early (15 ± 3 weeks) and mid (27 ± 3 weeks)-pregnancy. Clinical measures (BP, GDM diagnosis, weight) and blood samples were collected across pregnancy. Multiple linear and logistic regression models assessed associations of early pregnancy DQ with plasma lipids at early and mid-pregnancy, BP at three antenatal visits, GDM diagnosis and total GWG. Results: Maternal DQ scores ([mean ± SD]) decreased significantly from early (70.7 ± 11.4) to late pregnancy (66.5 ± 12.6) (p < 0.0005). At a false discovery rate of 0.2, early pregnancy DQ was significantly associated with 13 plasma lipids at mid-pregnancy, including negative associations with six triglycerides (TGs); TG(54:0)[NL-18:0] (neutral loss), TG(50:1)[NL-14:0], TG(48:0)[NL-18:0], TG(52:1)[NL-18:0], TG(54:1)[NL-18:1], TG(50:0)[NL-18:0]. No statistically significant associations were found between early pregnancy DQ and BP, GDM or GWG. Conclusion: Maternal diet did not adhere to Australian Dietary Guidelines. Diet quality was inversely associated with multiple plasma TGs. This study provides novel insights into the relationship between DQ, lipid biomarkers and cardiometabolic health during pregnancy. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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