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Start Over Author "P., Kwee" Journal european journal of nuclear medicine and molecular imaging
30 results on '"P., Kwee"'

3. PET/MRI in practice: a clinical centre survey endorsed by the European Association of Nuclear Medicine (EANM) and the EANM Forschungs GmbH (EARL)

Author

Prakken, Niek H. J., Besson, Florent L., Borra, Ronald J. H., Büther, Florian, Buechel, Ronny R., Catana, Ciprian, Chiti, Arturo, Dierckx, Rudi A. J. O., Dweck, Marc R., Erba, Paola A., Glaudemans, Andor W. J. M., Gormsen, Lars C., Hristova, Ivalina, Koole, Michel, Kwee, Thomas C., Mottaghy, Felix M., Polycarpou, Irene, Prokop, Mathias, Stegger, Lars, Tsoumpas, Charalampos, and Slart, Riemer H. J. A.

Published
2023
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7. An international expert opinion statement on the utility of PET/MR for imaging of skeletal metastases

Author

Husseini, Jad S., Amorim, Bárbara Juarez, Torrado-Carvajal, Angel, Prabhu, Vinay, Groshar, David, Umutlu, Lale, Herrmann, Ken, Cañamaque, Lina García, Garzón, José Ramón García, Palmer, William E., Heidari, Pedram, Shih, Tiffany Ting-Fang, Sosna, Jacob, Matushita, Cristina, Cerci, Juliano, Queiroz, Marcelo, Muglia, Valdair Francisco, Nogueira-Barbosa, Marcello H., Borra, Ronald J. H., Kwee, Thomas C., Glaudemans, Andor W. J. M., Evangelista, Laura, Salvatore, Marco, Cuocolo, Alberto, Soricelli, Andrea, Herold, Christian, Laghi, Andrea, Mayerhoefer, Marius, Mahmood, Umar, Catana, Ciprian, Daldrup-Link, Heike E., Rosen, Bruce, and Catalano, Onofrio A.

Published
2021
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10. Lesion detection by [89Zr]Zr-DFO-girentuximab and [18F]FDG-PET/CT in patients with newly diagnosed metastatic renal cell carcinoma

Author

Verhoeff, Sarah R., van Es, Suzanne C., Boon, Eline, van Helden, Erik, Angus, Lindsay, Elias, Sjoerd G., Oosting, Sjoukje F., Aarntzen, Erik H., Brouwers, Adrienne H., Kwee, Thomas C., Heskamp, Sandra, Hoekstra, Otto S., Verheul, Henk, van der Veldt, Astrid A. M., de Vries, Elisabeth G. E., Boerman, Otto C., van der Graaf, Winette T. A., Oyen, Wim J. G., and van Herpen, Carla M. L.

Published
2019
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30. Cardiac iodine-123 metaiodobenzylguanidine uptake in animals with diabetes mellitus and/or hypertension

Author

Dubois, Eric A., Kam, Kwee Lan, Somsen, G. Aernout, Boer, Gerard J., de Bruin, Kora, Batink, Harry D., Pfaffendorf, Martin, van Royen, Eric A., and van Zwieten, Pieter A.

Abstract

The aim of the present study was to evaluate the use of the noradrenaline analogue iodine-123 metaiodobenzylguanidine ([123I]MIBG) for the assessment of cardiac sympathetic activity in the presence of diabetes mellitus and/or hypertension in animal models. One model used Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) rendered diabetic at 12 weeks of age by an intravenous injection of streptozotocin (STZ). The other model used lean and obese Zucker rats. In all groups basic haemodynamic values were established and animals received an intravenous injection of 50 µCi [123I]MIBG. Initial myocardial uptake and washout rates of [123I]MIBG were measured scintigraphically during 4 h. After sacrifice, plasma noradrenaline and left cardiac ventricular ß-adrenoceptor density was determined. The diabetic state, both in STZ-treated rats (direct induction) and in obese Zucker rats (genetic induction), appeared to induce a lower cardiac density of ß-adrenoceptors, indicative of increased sympathetic activity. Cardiac [123I]MIBG then showed increased washouts, thereby confirming enhanced noradrenergic activity. This parallism of results led to the conclusion that [123I]MIBG wash-out measurements could provide an excellent tool to assess cardiac sympathetic activity non-invasively. However, in hypertension (WKY vs SHR), both parameters failed to show parallelism: no changes in ß-adrenoceptor density were found, whereas [123I]MIBG wash-out rate was increased. Thus, either [123I]MIBG washout or ß-adrenoceptor density may not be a reliable parameter under all circumstances to detect changes in the release of noradrenaline. Changes in the initial uptake of [123I]MIBG were observed as well. This may be a good marker for the disappearance of cardiac innervation, but it seems not to be a good parameter for distinguishing between loss of sympathetic innervation and enhanced uptake of noradrenaline in pathological conditions.

Published
1996
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