1. Technetium-99m tetrofosmin for parathyroid scintigraphy: a direct comparison with (99m)Tc-MIBI, (201)Tl, MRI and US
- Author
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Hiroto Yamashita, Shigemi Futami, Hiroyuki Yamashita, Shozo Tamura, Hideyuki Wakamatsu, Shiro Noguchi, Shigeki Nagamachi, and Seishi Jinnouchi
- Subjects
Adult ,Male ,Technetium Tc 99m Sestamibi ,medicine.medical_specialty ,Scintigraphy ,Sensitivity and Specificity ,Technetium (99mTc) sestamibi ,Isotopes of technetium ,Parathyroid Glands ,Organophosphorus Compounds ,Technetium-99 ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Radionuclide Imaging ,Parathyroid adenoma ,Aged ,Hyperparathyroidism ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,General Medicine ,Organotechnetium Compounds ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Thallium Radioisotopes ,Parathyroid scintigraphy ,Case-Control Studies ,Subtraction Technique ,Female ,Radiology ,Radiopharmaceuticals ,Nuclear medicine ,business ,medicine.drug - Abstract
The aim of this study was to evaluate the efficacy and role of technetium-99m tetrofosmin for the detection of abnormal parathyroid glands to be referred for surgical treatment. Twenty-eight consecutive patients, including 25 primary and 3 secondary cases of hyperparathyroidism, were evaluated. (99m)Tc-tetrofosmin/(99m)Tc-pertechnetate subtraction scintigraphy (TF/Tc) was performed on all patients, and the results were directly compared with those of (99m)Tc-methoxyisobutylisonitrile (MIBI)/(99m)Tc-pertechnetate subtraction scintigraphy (MIBI/Tc), (201)Tl/(99m)Tc-pertechnetate subtraction scintigraphy (Tl/Tc), magnetic resonance imaging (MRI) and ultrasonography (US). In cases of single-gland disease, the sensitivities of TF/Tc, MIBI/Tc, Tl/Tc, MRI and US were 63.2%, 68.4%, 57.9%, 55.6% and 63.2%, respectively. In cases of multi-gland disease, the sensitivities of TF/Tc, MIBI/Tc, Tl/Tc, MRI and US were 41.7%, 41.7%, 37.5%, 58.3% and 54.2%, respectively. In cases of parathyroid adenoma, the sensitivities of TF/Tc, MIBI/Tc, Tl/Tc, MRI and US were 68.8%, 75.0%, 68.8%, 62.5% and 75.0%, respectively. In cases of parathyroid hyperplasia, the sensitivities of TF/Tc, MIBI/Tc, Tl/Tc, MRI and US were 40.7%, 40.7%, 33.3%, 53.8% and 48.1%, respectively. It is concluded that, for the detection of abnormal parathyroid glands, (99m)Tc-tetrofosmin is as useful as (99m)Tc-MIBI and is more useful than (201)Tl.
- Published
- 2001