1. Chemoenzymatic synthesis and antimicrobial activity evaluation of monogalactosyl diglycerides
- Author
-
Francesca Cateni, Paolo Bonivento, Giuseppe Procida, Marina Zacchigna, Luciana Gabrielli Favretto, Giuditta Scialino, Elena Banfi, Cateni, Francesca, Bonivento, P, Procida, Giuseppe, Zacchigna, Marina, Gabrielli, Luciana, Scialino, Giuditta, and Banfi, Elena
- Subjects
Pharmacology ,Bacteria ,Synthesi ,Organic Chemistry ,2-O-Diacyl-3-O-b-D-galactopyranosyl-glycerols ,Fungi ,General Medicine ,Microbial Sensitivity Tests ,Antimicrobial activity ,Mass Spectrometry ,Diglycerides ,Monogalactosyl diglyceride ,Synthesis ,Anti-Infective Agents ,Drug Discovery ,Monogalactosyl diglycerides ,1 ,Lipases ,2-O-Diacyl-3-O-b-D-galactopyranosyl-glycerol - Abstract
Monogalactosyl diglycerides with medium to long fatty acid acyl chains, were prepared and examined for antimicrobial activity against Gram positive, Gram negative bacteria and fungi. The study of their in vitro antimicrobial activity confirms the significant activity of some monogalactosyl diacylglycerol analogues and establishes for the galactose series that the 1,2-disubstitution and the octanoyl chain are the proper structural features for the maximum activity.
- Published
- 2006