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Start Over Author "Luu Duc C" Journal european journal of medicinal chemistry
6 results on '"Luu Duc C"'

6. Synthesis of 4-octyl-2H-1,4-benzo-thiazin-3-ones.

Author

Guarda VL, Perrissin M, Thomasson F, Ximenes EA, Galdino SL, Pitta IR, Luu-Duc C, and Barbe J

Subjects
Acylation, Alkylation, Anti-Infective Agents pharmacology, Hydrolysis, Microbial Sensitivity Tests, Structure-Activity Relationship, Thiazines pharmacology, Anti-Infective Agents chemical synthesis, Thiazines chemical synthesis
Abstract

Synthesis, physical and analytical properties of 6-alkylacylamino-4-octyl-2H-1,4-benzo-thiazin-3-ones derivatives are described. These new compounds were prepared by acylation and/or alkylation of the amino group under phase transfer catalysis conditions. Acid hydrolysis of the alkylacylamino-2H-1,4-benzo-thiazin-3-ones afforded N-alkylamino-benzothiazin-3-ones. Some of these compounds were evaluated in vitro for possible bacteriostatic activity.

Published
2003
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