1. Synthesis and preclinical evaluation of [
- Author
-
Muneer, Ahamed, Bala, Attili, Daisy, van Veghel, Maarten, Ooms, Philippe, Berben, Sofie, Celen, Michel, Koole, Lieven, Declercq, Juha R, Savinainen, Jarmo T, Laitinen, Alfons, Verbruggen, and Guy, Bormans
- Subjects
Dose-Response Relationship, Drug ,Molecular Structure ,Brain ,Macaca mulatta ,Monoacylglycerol Lipases ,Piperazines ,Rats ,Mice ,Structure-Activity Relationship ,Positron-Emission Tomography ,Benzyl Compounds ,Animals ,Female ,Tissue Distribution ,Enzyme Inhibitors ,Radioactive Tracers ,Rats, Wistar - Abstract
MAGL is a potential therapeutic target for oncological and psychiatric diseases. Our objective was to develop a PET tracer for in vivo quantification of MAGL. We report [
- Published
- 2017