1. Synthesis and biological evaluation of vanadium complexes as novel anti-tumor agents.
- Author
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Lu, Ling-Pan, Suo, Feng-Zhi, Feng, Ya-Li, Song, Li-Li, Li, Ying, Li, Yang-Jie, and Wang, Kai-Ti
- Subjects
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BIOSYNTHESIS , *VANADIUM , *CANCER cells , *STRUCTURE-activity relationships , *CELL lines - Abstract
A class of vanadium complexes were prepared and investigated for their antiproliferative effects by MTT assay. The structure-activity relationship was extensively studied through the ligand variation. The results showed that the synthetic vanadium complexes demonstrated moderate to good antiproliferative activities against the four cancer cell lines including MGC803, EC109, MCF7 and HepG2, respectively. Of note was that most of the complexes showed preferential growth inhibitory activity to some degree toward gastric cancer line MGC803. Among them, complex 19 exhibited the most and broad-spectrum proliferative inhibition against the tested cell lines. In addition, mechanism studies illustrated that complex 19 could prevent the colony formation, migration and EMT process, as well as induce apoptosis of MGC803 cells. Furthermore, Western blot experiments revealed that the expression of apoptosis-related proteins changed, including up-regulation of Bax, PARP and caspase-3/9, as well as down-regulation of Bcl-2. Image 1 • A library of vanadium complexes showed moderate to good growth inhibition against the tested cancer cells. • Complex 19 demonstrated the best as well as selective proliferation inhibition toward MGC-803 cells. • Complex 19 inhibited the cell colony formation, migration and EMT process of MGC803. • Complex 19 induced the apoptosis of MGC-803 cells, and led to the expression changes of key proteins related to apoptosis. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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