1. Design and synthesis of novel protein kinase CK2 inhibitors on the base of 4-aminothieno[2,3-d]pyrimidines.
- Author
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Ostrynska, Olga V., Balanda, Anatoliy O., Bdzhola, Volodymyr G., Golub, Andriy G., Kotey, Igor M., Kukharenko, Olexander P., Gryshchenko, Andrii A., Briukhovetska, Nadiia V., and Yarmoluk, Sergiy M.
- Subjects
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PROTEIN kinase CK2 , *PROTEIN kinase inhibitors , *PYRIMIDINE derivatives , *BINDING sites , *DRUG design , *DRUG synthesis - Abstract
An extension of our previous research work has resulted in a number of new ATP-competitive CK2 inhibitors that have been identified among 4-aminothieno[2,3-d]pyrimidine derivatives. The most active compounds obtained in the course of the research are 3-(5-p-tolyl-thieno[2,3-d]pyrimidin-4-ylamino)-benzoic acid, 5e ( NHTP23 , IC 50 = 0.01 μM), 3-(5-phenyl-thieno[2,3-d]pyrimidin-4-ylamino)-benzoic acid, 5g ( NHTP25 , IC 50 = 0.065 μM) and 3-(6-methyl-5-phenyl-thieno[2,3-d]pyrimidin-4-ylamino)-benzoic acid, 5n ( NHTP33 , IC 50 = 0.008 μM). Structure–activity relationships of the tested 4-aminothieno[2,3-d]pyrimidine derivatives have been studied and their binding mode with ATP-acceptor site of CK2 has been proposed. A negative effect of intramolecular hydrogen bonding in the compounds’ structure is discussed. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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