Search

Your search keyword '"Frankevich, Vladimir"' showing total 8 results
Start Over Author "Frankevich, Vladimir" Journal european journal of mass spectrometry
8 results on '"Frankevich, Vladimir"'

2. Relative quantitation of phosphatidylcholines with interfered masses of protonated and sodiated molecules by tandem and Fourier-transform ion cyclotron resonance mass spectrometry

Author

Chagovets, Vitaliy, primary, Kononikhin, Aleksey, additional, Tokoreva, Alisa, additional, Bormotov, Denis, additional, Starodubtseva, Nataliia, additional, Kostyukevich, Yury, additional, Popov, Igor, additional, Frankevich, Vladimir, additional, and Nikolaev, Eugene, additional

Published
2019
Full Text
View/download PDF

3. The high-resolution mass spectrometry study of the protein composition of amyloid-like urine aggregates associated with preeclampsia

Author

Sergeeva, Victoria A, Zakharova, Natalia V, Bugrova, Anna E, Starodubtseva, Natalia L, Indeykina, Maria I, Kononikhin, Alexey S, Frankevich, Vladimir E, and Nikolaev, Eugene N

Abstract

The study of protein misfolding and post-translational processing abnormalities is a promising diagnostic approach for socially significant pathologies associated with the accumulation of abnormal forms of proteins. Recently, it was shown that amyloid-like aggregates can be observed in the urine of pregnant women with preeclampsia, which is the most severe hypertensive complication that can lead to fateful outcomes. The protein composition of urine aggregates may clarify the molecular mechanisms underlying the pathology and has not yet been studied in detail. Using a proteomic approach based on high-resolution mass spectrometry, we studied the protein composition of amyloid-like structures that aggregate in the presence of Congo red azo-dye in the urine of pregnant women with preeclampsia. Fragments of β-sheets of α-1-antitrypsin, complement 3, haptoglobin, ceruloplasmin, and trypstatin were identified as most likely targets for Congo red binding.

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results