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Oral rehabilitation by means dental implants is a surgical procedure with high standards of success. Since very few reports focus on clinical success related to implant site and no report is available on a new type of implants (FMD srl, Rome, Italy), a retrospective study was performed. A total of 390 two-piece implants were inserted, 213 in females and 177 in males. The median age was 59 ± 11 (min-max 24–80 years). Two hundred and five implants were inserted in upper jaw and 185 in mandible. Three implants were lost, survival rate = 99.23%. Among the studies variables immediate loaded implants on single tooth rehabilitations (p=0.047) have a worse clinical outcome. Then peri-implant bone resorption (i.e. delta IAJ) was used to investigate SCR. Among the remaining 387 implants, 47 fixtures have a crestal bone resorption greater than 1.5 mm (SCR = 87.85). Statistical analysis demonstrated that no studied variable has an impact on clinical outcome and thus there are no differences in term of SVR and SCR by sites. In conclusion FMD implants are reliable devices for oral rehabilitation with a very high SCR and SVR.

Nowadays, research on orthopedic and dental implants is focused on titanium alloys due to their appropriated mechanical properties and corrosion resistance in the body environment. Another important aspect to be investigated is their surface topography, which is very important to osseointegration. The aim of this study was to assess dental pulp stem cells response to different titanium surface topography modified. Mesenchymal stem cell marker ENG was significantly decreased in stem cells cultivated in modified titanium surface respect to machined titanium surface, indicating the differentiation effect of this biomaterial on stem cells. The obtained results can be relevant to better understand the molecular mechanism of bone regeneration and as a model for comparing other materials with similar clinical effects.

In the last two decades, several investigators have reported immediate placement of dental implants into extraction sockets achieving excellent results with a two-stage surgical procedure. Recently immediate loading has become an emerging technique as it has been documented to be a successful and time saving procedure. As regard the possibility of immediate/early loading of implants placed in fresh extraction sockets few reports are available. In addition they are based on limited series with short follow-up. Thus we decided to perform a retrospective study on a series of post-extractive implants. A total of 40 two-piece implants (FMD srl, Rome, Italy) were inserted in post extractive sockets, 22 in females and 18 in males. The median age was 52 ± 11 (min-max 24–69 years). Twenty-one implants were inserted in upper jaw and 19 in mandible. Fixtures replaced 7 incisors, 3 cuspids, 12 premolars and 18 molars. Implant' length was x ≤ 10 mm, 10,30 ≤ x ≤ 12.30, equal to 13 mm and x ≥14 mm in 6,14,9, and 11 cases, respectively. Implant' diameter was narrower than 3.5 mm, equal to 3.8 mm and wider than 4.0 mm in 1,7, and 32 cases, respectively. There were 28, 2 and 10 Elisir, I-fix, and Shiner implant types, respectively. No implant on single tooth rehabilitations, was lost, survival rate = 100%. Then peri-implant bone resorption (i.e. delta IAJ) was used to investigate SCR. Seven fixtures have a crestal bone resorption greater than 1.5 mm (SCR = 82.5%). Statistical analysis demonstrated that there was a difference between surgeons (p= 0.005). In conclusion FMD implants are reliable devices for oral rehabilitation with a very high SCR and SVR.

Implant prostheses are often used to restore partially or completely edentulous patients but limited bone height, especially in the posterior mandible, may restrict the use of dental implants. Short implants (i.e. x ≤ 10 mm) may be selected in these situations. They have several advantages: 1 - restricting the need for sophisticated and expensive surgical procedures like sinus lifting, bone grafting and mandibular nerve transposition, 2 - placing short-span dentures and 3 - avoiding cantilevers in the posterior sextants. The limited surface area of SIs, conversely, can be a potential disadvantage as it has less resistance to occlusal forces. Since no report is available on a new type of implants, a retrospective study was performed. A total of 148 short (i.e x ≤ 10 mm) two-piece implants (FMD srl, Rome, Italy) were inserted, 91 in female and 57 in males. The median age was 58 ± 12 (min-max 25–80 years). Implants were inserted 68 in the maxilla and 80 in the mandible. One implant was lost, survival rate = 98.52%. Among the studies variables post-extractive implants on single tooth rehabilitations (p=0.043) was the only significant variable. Then peri-implant bone resorption (i.e. delta IAJ) was used to investigate SCR. Among the remaining 147 implants, 18 fixtures have a crestal bone resorption greater than 1.5 mm (SCR = 87.75). Statistical analysis demonstrated that only diabetes has a negative impact on peri-implant crestal bone resorption (p=0.016). In conclusion FMD implants are reliable devices for oral rehabilitation with a very high SCR and SVR.

The rehabilitation of the edentulous maxilla is a relatively common clinical problem and to submerge dental implants during the healing period is a major prerequisite to obtain implant osseointegration. It is believed that micromovement of implants, due to functional forces at the bone-implant interface during wound healing, could induce the formation of fibrous tissue rather than bone, leading to a clinical failure. In addition, the coverage of an implant is also thought necessary to prevent infection and epithelial down-growth. Usually, the second surgical procedure was performed after three months in the mandible and six months in the maxilla. Since no report is available on a new type of implants, a retrospective study was performed on fixtures inserted in upper jaw. A total of 205 two-piece implants (FMD srl, Rome, Italy) were inserted in maxilla, 111 in female and 94 in males. The median age was 59 ± 10 (min-max 24–80 years). Twenty four diabetic patients were enrolled, 141 had periodontal disease and 96 were smokers. Two surgeons performed operation. Fixtures were placed in 6 totally edentulous patient, 9 single missing teeth and 190 partially edentulous subjects. Twenty one implants were placed in post-extraction sockets; GBR was performed onto 26 fixtures and 3 were immediately loaded. There were 109 single crowns, 96 implants bearing 2 or greater bridges. Two implants were lost, survival rate = 99.02%. Among the studies variables immediate loaded implants on single tooth rehabilitations (p=0.03) have a worse clinical outcome. Then peri-implant bone resorption (i.e. delta IA J) was used to investigate SCR. Among the remaining 203 implants, 20 fixtures have a crestal bone resorption greater than 1.5 mm (SCR = 89.13). Statistical analysis demonstrated that diabetes (p=0.001) and periodontal disease (p=0.047) had a worse outcome. In conclusion FMD implants are reliable devices for oral rehabilitation with a very high SCR and SVR.

Titanium (Ti) is the most widely used material in implantology for dental, orthopedic and maxillofacial purposes due to their excellent biocompatibility and mechanical properties Several data suggest that implant anchorage to bone and soft tissue can be modulated by surface characteristics. Fibroblasts are the soft tissues cells concerned in producing extracellular matrix and collagen. The aim of this work is to compare five different titanium surface treatments in order to investigate which one had the best behavior using Human Fibroblast (HFb) after seven days in culture medium. The expression levels of some adhesion and traction-resistance related genes (COL11A1, COL2A1, COL9A1, DSP, ELN, HAS1, and TFRC) were analyzed using real time Reverse Transcription-Polymerase Chain Reaction (real time RT-PCR). Titanium disks can lead to implant integration promoting the production of protein involved in cell-cell and cell-matrix adhesion and in stress-resistance, required for a good outcome in dental implantology

In the last decade the use of wide diameter implants (WDI, i.e. diameter > 3.75 mm) has increased especially in posterior jaws because it is generally accepted that WDI: 1- improve the ability of posterior implants to tolerate occlusal forces, 2- create a wider base for proper prosthesis, and 3- avoid placing two standard-size implants (SSI = 3.75 mm) at one site to obtain a double-root prosthetic tooth. Since no report is available on a new type of implants, a retrospective study was performed. A total of 124 two-piece implants (FMD srl, Rome, Italy) were inserted, 56 in female and 68 in males. The median age was 59 ± 12 (min-max 28–75 years). Implants were inserted 59 in the maxilla and 65 in the mandible; they replaced 7 incisors, 4 cuspids, 23 premolars and 90 molars. One implant was lost, survival rate = 99.20%. Among the studies variables immediate loaded implants (p=0.05) and upper jaw (p=0.005) have a statistically significant worse outcome. Then peri-implant bone resorption (i.e. delta IAJ) was used to investigate SCR. Among the remaining 123 implants, 2 fixtures have a crestal bone resorption greater than 1.5 mm (SCR = 97.54). Statistical analysis demonstrated that single crown have a higher peri-implant crestal bone resorption if compared with bridge supported by 2 or more implants (p=0.03). In conclusion FMD implants are reliable devices for oral rehabilitation with a very high SCR and SVR.

Narrow diameter implants (NDI) (i.e. diameter 3.75 mm) are a potential solution for specific clinical situations such as reduced interradicuiar bone, thin alveolar crest and replacement of teeth with small cervical diameter. NDI have been available in clinical practice since the nineties but only a few studies have analyzed their clinical outcome. Since no report is available on a new type of implants, a retrospective study was performed. A total of 47 narrow diameter (i.e. x ≤ 3.40 mm) two-piece implants (FMD srl, Rome, Italy) were inserted, 35 in females and 12 in males. The median age was 60 ± 11 (min-max 30–80 years). Implants were inserted 22 in the maxilla and 25 in the mandible; they replaced 11 incisors, 3 cuspids, 21 premolars and 12 molars. Implant' length was shorter than 10 mm, 10.30 ≤ x ≤ 12.30, equal to 13 mm and longer than 13 mm in 17,28,1 and 1 fixtures, respectively. Implant' diameter was narrower than 3.5 mm. There were 3,18 and 26 Elisir, I-fix and Shiner implant types. No implant on single tooth rehabilitations was lost and thus survival rate was 100%. Then peri-implant bone resorption (i.e. delta IAJ) was used to investigate SCR. Seven fixtures have a crestal bone resorption greater than 1.5 mm (SCR = 85.1). Statistical analysis demonstrated that diabetes (p=0.044) and smoke (p=0.001) have a higher peri-implant crestal bone resorption. In conclusion FMD implants are reliable devices for oral rehabilitation with a very high SCR and SVR although smoker and diabetic patients have a worse clinical outcome.

Titanium and titanium alloys are widely used as implant materials due to their excellent biocompatibility and mechanical properties. The aim of this work is to compare five different titanium layers in order to investigate which one had a greater osteoconductive power using Human Osteoblasts (HObs) culture for seven days on these surfaces. The expression levels of some bone-related genes (ALPL, COL1A1, COL3A1, SPP1, RUNX2 and SPARC) were analyzed using real time Reverse Transcription-Polymerase Chain Reaction (real time RT-PCR). Results obtained in this study demonstrate that titanium disks can lead to osteoblast differentiation and extracellular matrix deposition and mineralization by the activation of different osteoblast genes in relation to the specific type of surface treatment.

It is generally accepted that the mandible (especially in the interforaminal region) has better bone quality than the maxilla, and this fact is probably the reason why several reports are available regarding implants inserted into the mandible. Since no report is available on a new type of implants, a retrospective study was performed. A total of 185 two-piece implants (FMD srl, Rome, Italy) were inserted in mandible, 102 in female and 83 in males. The median age was 58 ± 13 (min-max 25–80 years). Implants replaced 14 incisors, 7 cuspids, 49 premolars and 115 molars. Implant' length was x ≤ 10 mm, 10,30 ≤ x ≤ 12.30, equal to 13 mm and x ≥14 mm in 80, 90,13 and 2 cases, respectively. Implant' diameter was narrower than 3.5 mm, equal to 3.8 mm and wider than 4.0 mm in 25, 17,143 cases, respectively. There were 36,41,106 and 2 Elisir, I-fix, Shiner, and Storm implant types, respectively. One implant was lost, survival rate = 98.15%. Among the studies variables immediate loaded implants on single tooth rehabilitations (p=0.017) have a worse clinical outcome. Then peri-implant bone resorption (i.e. delta IAJ) was used to investigate SCR. Among the remaining 184 implants, 20 fixtures have a crestal bone resorption greater than 1.5 mm (SCR = 89.13). Statistical analysis demonstrated signifiance only for surgeon (p=0.001). In conclusion FMD implants are reliable devices for oral rehabilitation with a very high SCR and SVR.