Search

Your search keyword '"Michaëlsson, Jakob"' showing total 9 results
Start Over Author "Michaëlsson, Jakob" Journal european journal of immunology
9 results on '"Michaëlsson, Jakob"'

1. Composition and functionality of the intrahepatic innate lymphoid cell‐compartment in human nonfibrotic and fibrotic livers

Author

Forkel, Marianne, primary, Berglin, Lena, additional, Kekäläinen, Eliisa, additional, Carlsson, Adrian, additional, Svedin, Emma, additional, Michaëlsson, Jakob, additional, Nagasawa, Maho, additional, Erjefält, Jonas S, additional, Mori, Michiko, additional, Flodström‐Tullberg, Malin, additional, Bergquist, Annika, additional, Ljunggren, Hans‐Gustaf, additional, Westgren, Magnus, additional, Lindforss, Ulrik, additional, Friberg, Danielle, additional, Jorns, Carl, additional, Ellis, Ewa, additional, Björkström, Niklas K, additional, and Mjösberg, Jenny, additional

Published
2017
Full Text
View/download PDF

2. Tracing dynamic expansion of human NK ‐cell subsets by high‐resolution analysis of KIR repertoires and cellular differentiation

Author

Béziat, Vivien, primary, Traherne, James, additional, Malmberg, Jenny‐Ann, additional, Ivarsson, Martin A., additional, Björkström, Niklas K., additional, Retière, Christelle, additional, Ljunggren, Hans‐Gustaf, additional, Michaëlsson, Jakob, additional, Trowsdale, John, additional, and Malmberg, Karl‐Johan, additional

Published
2014
Full Text
View/download PDF

8. Loss or mismatch of MHC class I is sufficient to trigger NK cell-mediated rejection of resting lymphocytes in vivo - role of KARAP/DAP12-dependent and -independent pathways.

Author

Öberg, Linda, Johansson, Sofia, Michaëlsson, Jakob, Tomasello, Elena, Vivier, Eric, Kärre, Klas, and Höglund, Petter

Abstract

A prediction from the "missing self" hypothesis is that down-regulation of MHC class I on resting hematopoietic cells should be sufficient to make them susceptible to NK cell killing. Using a method enabling kinetic and quantitative assessments of NK cell-mediated rejection responses in vivo, we here show that resting hematopoietic cells from β-microglobulin-deficient (βm) mice were rapidly rejected in unmanipulated C57BL/6 (B6) mice. In situations of allelic MHC class I mismatches rejection occurred but required longer time. βm donor cells pre-activated with concanavalin A were more efficiently eliminated compared to resting cells, as were MHC tumor cells. When recipient mice were pretreatedwith an IFN inducer to activate NK cells, rejection was also enhanced. The signaling adaptor KARAP/DAP12 was dispensable for rejection of βm cells (lacking MHC) but critical for rejection of BALB/c cells (mismatched MHC) in unmanipulated B6 recipients. In contrast, B6 recipients with pre-activated NK cells rejected BALB/c cells in a KARAP/DAP12-independent fashion. Loss or mismatch of MHC class I in resting cells was thus sufficient to convey susceptibility to NK cell rejection. However, activation of the effector or the target enhanced rejection and shifted the balance between different signaling pathways involved. [ABSTRACT FROM AUTHOR]

Published
2004
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results