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Start Over Author "Danzl NM" Journal european journal of immunology

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1. Rapid thymectomy of NSG mice to analyze the role of native and grafted thymi in humanized mice.

Author

Khosravi-Maharlooei M, Hoelzl M, Li HW, Madley RC, Waffarn EE, Danzl NM, and Sykes M

Subjects
Animals, Humans, Mice, Mice, Inbred NOD, Mice, SCID, Thymectomy methods, Thymus Gland immunology, Thymus Gland transplantation, Transplantation, Heterologous methods
Abstract

We developed a rapid method to remove the native mouse thymus from NSG mice, which allowed us to compare the behavior of human immune cells in the presence or absence of human T cells in human immune system mice. Removing the native mouse thymus is critical for studies of human thymopiesis in grafted thymic tissue in humanized mice., (© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Published
2020
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