1. Levosimendan improves renal function in acute decompensated heart failure: possible underlying mechanisms
- Author
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Francesco Fedele, Noemi Bruno, Carmen Caira, Massimo Mancone, Bruno Brasolin, and Alessandra D'Ambrosi
- Subjects
Creatinine ,Kidney ,medicine.medical_specialty ,Acute decompensated heart failure ,business.industry ,Renal function ,Levosimendan ,urologic and male genital diseases ,medicine.disease ,chemistry.chemical_compound ,medicine.anatomical_structure ,chemistry ,Internal medicine ,Heart failure ,Renal blood flow ,medicine.artery ,medicine ,Cardiology ,Renal artery ,Cardiology and Cardiovascular Medicine ,business ,medicine.drug - Abstract
Aims The cardio-renal syndrome plays a critical role in acute heart failure (HF). Levosimendan, an inodilator drug, has a positive but controversial effect on kidney. Our aim was to evaluate its effects on both renal and systemic haemodynamic parameters as well as on renal function, explaining the possible mechanisms involved. Methods and results Patients with acute decompensated HF, moderate renal impairment, wedge pressure >20 mmHg and EF
- Published
- 2013
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