1. Residual stress ischaemia is associated with blood markers of myocardial structural remodelling
- Author
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Wassila Djaballah, Pierre Y. Marie, Jean M Virion, J. Capiaumont, Anca Radauceanu, Etienne Aliot, Brigitte Dousset, Frédéric Moulin, Façez Zannad, Gilles Karcher, and François Alla
- Subjects
Male ,Cardiac function curve ,medicine.medical_specialty ,Heart Ventricles ,Myocardial Ischemia ,Ischemia ,Coronary Artery Disease ,Coronary artery disease ,Fibrosis ,Internal medicine ,medicine ,Humans ,cardiovascular diseases ,Blood markers ,Exercise ,Tomography, Emission-Computed, Single-Photon ,Ejection fraction ,business.industry ,Myocardium ,Stroke Volume ,Middle Aged ,medicine.disease ,Adaptation, Physiological ,Oxidative Stress ,Collagen Type III ,Heart failure ,Concomitant ,Cardiology ,Female ,Hypertrophy, Left Ventricular ,Cardiology and Cardiovascular Medicine ,business ,Biomarkers - Abstract
Background: Long-term prognosis of coronary artery disease (CAD) patients is worsened when stress ischemia persists on treatment, but the relationship with adverse cardiac remodelling had never been investigated. Aim: To analyze changes in blood markers of fibrosis in patients with chronic CAD exhibiting exercise ischaemia. Methods: Circulating markers of collagen: (i) turnover (amino-terminal propeptide of collagen-III [PIIINP]) and (ii) degradation (matrix metalloproteinase 1 [MMP-1]), were obtained in 139 CAD patients referred for exercise 201Tl-SPECT. Results: In the 57 patients who had SPECT-ischaemia, PIIINP was higher (4.3±2.9 μg L−1 vs. 3.1±1.5 μg L−1, p=0.002) and MMP-1 lower (3.8±2.1 μg L−1 vs. 4.7±2.8 μg L−1, p=0.04) than in the 82 patients without SPECT-ischaemia. PIIINP was independently related to LV volume, SPECT-ischaemia and age, whereas MMP-1 was related to current treatment with ACEI and β-blockers (p
- Published
- 2007