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Saviola A, Luppi M, Potenza L, Morselli M, Bresciani P, Ferrari A, Riva G, Torelli G. Myocardial ischemia in a patient with acute lymphoblastic leukemia during l-asparaginase therapy. Eur J Haematol 2004: 72: 71–72. © Blackwell Munksgaard 2004. Haemostatic abnormalities may occur in 1–2% of patients treated with l-asparaginase. Here, we present the second case of a myocardial infarction, developing in a patient with acute lymphoblastic leukemia (ALL), in the course of l-asparaginase treatment. In our patient and in the only one reported case from the literature, a recent exposure to vincristine and daunorubicin was also reported, but induction chemotherapy program was completed as scheduled, with the only withdrawal of l-asparaginase. Myocardial infarction should be included in the list of thrombotic complications possibly associated with l-asparaginase treatment, or with a combination of l-asparaginase and vinca alkaloids/anthracycline. [ABSTRACT FROM AUTHOR]