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Your search keyword '"Régis Costello"' showing total 3 results
Start Over Author "Régis Costello" Journal european journal of haematology
3 results on '"Régis Costello"'

1. Could daratumumab induce the maturation of plasmablasts in Plasmablastic lymphoma?-Potential therapeutic applications

Author

Régis Costello, Raphaelle Fanciullino, Hubert Lepidi, Geoffroy Venton, Pauline Roche, Cédric Mercier, J Colle, Laure Farnault, Shirley Fritz, Yael Berda-Haddad, Vadim Ivanov, Antoine Tichadou, Simulation and Modeling of Adaptive Response for Therapeutics in Cancer (SMARTc), Centre de Recherche en Cancérologie de Marseille (CRCM), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Aix Marseille Université (AMU), Méthodes computationnelles pour la prise en charge thérapeutique en oncologie : Optimisation des stratégies par modélisation mécaniste et statistique (COMPO), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Institut Paoli-Calmettes, and Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
business.industry, [SDV]Life Sciences [q-bio], Plasma Cells, Daratumumab, Antibodies, Monoclonal, Cell Differentiation, Hematology, General Medicine, medicine.disease, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, Antineoplastic Agents, Immunological, 030220 oncology & carcinogenesis, medicine, Cancer research, Plasmablastic Lymphoma, Humans, Molecular Targeted Therapy, business, Plasmablastic lymphoma, ComputingMilieux_MISCELLANEOUS, 030215 immunology
Abstract

International audience

Published
2020

2. New approaches in the immunotherapy of haematological malignancies

Author

Jerome Rey, Régis Costello, Cyril Fauriat, Daniel Olive, and Jean-Louis Gastaut

Subjects
medicine.medical_treatment, Immunosuppression, Hematology, General Medicine, Immunotherapy, Disease, Dendritic cell, Biology, medicine.disease, Lymphoma, Immune system, Cytokine, Immunology, medicine, Immunodeficiency
Abstract

Advances in the management of haematological malignancies have allowed to obtain improved remission rates. Nonetheless, relapses impair these results and justify the search for novel therapeutic strategies. Clinical data demonstrate that the immune system plays an important role in the control of haematological malignancies. An increased frequency of haematological malignancies is observed in immunodeficiency states. Reversal of the immunosuppression is sometimes sufficient to induce tumour regression (withdrawal of cyclosporine in post-transplant lymphoproliferations, highly active anti-retroviral treatment in human immunodeficiency virus related Kaposi's disease). Another line of evidence for the involvement of the immune system in the anti-tumour response comes from the observation of spontaneous anti-tumour responses that parallel the occurrence of paraneoplastic immune-mediated syndromes. Finally, the efficiency of allogeneic transplantation in the haematological field has been clearly demonstrated to depend on the immune-mediated graft vs. leukaemia effect. Nonetheless, tumours develop in immune competent patients because of various tumour escape mechanisms, such as loss of human leucocyte antigen class I antigens, absence of target recognition by deficient adhesion/co-stimulatory molecule expression, tumour cell counterattack against immune effectors, direct (contact-dependent) or indirect (cytokine-mediated) impairment of T-lymphocyte activation. Novel immunotherapy approaches are now orientated in a convergent direction, i.e. the reversal of immune escape mechanisms either via the correction of deficient phases of the immune response or by the amplification of physiological mechanisms.

Published
2003

3. Granular lymphoproliferative disorder, autologous blood stem cell transplantation and multiple myeloma

Author

Jerome Rey, Daniel Olive, Jean-Albert Gastaut, and Régis Costello

Subjects
Pathology, medicine.medical_specialty, business.industry, medicine.medical_treatment, Autologous blood, Lymphoproliferative disorders, Hematology, General Medicine, Hematopoietic stem cell transplantation, medicine.disease, Transplantation, medicine, Peripheral Blood Stem Cell Transplantation, Stem cell, business, Multiple myeloma
Published
2003

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