1. UGT1A1 (TA)
- Author
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Philippe, Joly, Céline, Renoux, Philippe, Lacan, Yves, Bertrand, Giovanna, Cannas, Nathalie, Garnier, Daniella, Cuzzubbo, Kamila, Kebaïli, Cécile, Renard, Alexandra, Gauthier, Vincent, Pialoux, Cyril, Martin, Marc, Romana, and Philippe, Connes
- Subjects
Male ,Adolescent ,Genotype ,Incidence ,Anemia, Sickle Cell ,alpha-Globins ,Cholelithiasis ,Risk Factors ,Child, Preschool ,Leukocytes ,Humans ,Female ,Glucuronosyltransferase ,Child ,Alleles ,Biomarkers ,Retrospective Studies - Abstract
Because of the increased hemolytic rate, a significant proportion of patients with sickle cell disease (SCD) are prone to develop cholelithiasis. The present study investigated the role of several genetic factors (UGT1A1 promoter (TA)One hundred and fifty-eight children (2-18 yr old) regularly followed at the University Hospital of Lyon (France) were included. A multivariate Cox model was used to test the associations between cholelithiasis and the different parameters analyzed.We confirmed that alpha-thalassemia and low basal reticulocyte (RET) count were independent protective factors for cholelithiasis while 7/7, 8/8 and 7/8 UGT1A1 (TA)Our findings demonstrate that UGT1A1 (TA)
- Published
- 2016