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Purpose: In this study, the effect of a germline BRCA1/2 mutation on survival outcomes in Korean patients with advanced high-grade serous ovarian cancer was investigated. Methods: This multicenter retrospective study involved six Korean institutions that included 63 patients with International Federation of Gynecology and Obstetrics stages IIIC or IV high-grade serous ovarian cancer, diagnosed surgically between January 2010 and December 2015, and who had undergone a BRCA mutation test during their follow-up period. Median progression-free survival and 5-year overall survival were measured and compared according to BRCA1/2 mutation status using the Kaplan-Meier method. Results: Of 63 patients, 28 (44.4%) patients with germline BRCA1/2 mutations were identified. Nineteen (30.2%) patients were identified with a germline BRCA1 mutation, and nine (14.3%) patients with a germline BRCA2 mutation. The median progression-free survival of patients with wild-type BRCA, or a BRCA1 or BRCA2 mutation was 15, 17 and 37 months, respectively. Wild-type BRCA and germline BRCA2 mutation groups showed a significant difference in progression-free survival (p = 0.009); however, a significant difference was not found between wild-type BRCA and germline BRCA1 mutation groups (p = 0.262). Five-year overall survival rates of patients with wild-type BRCA, or a BRCA1 or BRCA2 mutation were 65.9%, 67.5% and 87.5%, respectively; significant differences was not found between the three groups. Conclusion: In Patients with advanced high grade serous ovarian cancer, germline BRCA2 mutation group showed a significantly longer median progression-free survival compared to wild-type BRCA group. Five-year overall survival rates were not significantly different among the three groups. [ABSTRACT FROM AUTHOR]

Background: Mature cystic teratomas are the most frequent ovarian tumors; however, teratomas of extragonadal origin are extremely rare. The authors describe herein the first case simultaneously demonstrating normal ovaries and a mature cystic teratoma in the vesicovaginal space on laparoscopy. Case Report: A 23-year-old Korean nulliparous woman, with no disease history, was referred to the present outpatient clinic for an asymptomatic pelvic mass detected on routine checkup following a traffic accident. She underwent laparoscopy under a preoperative diagnosis of subserosal myoma in the left anterior wall of the uterus. A benign cystic tumor was found in the vesicovaginal space and was completely treated via laparoscopic resection. Conclusion: A mature cystic teratoma in the vesicovaginal space is extremely rare, and proper preoperative diagnosis of this lesion is difficult because of non-specific signs and symptoms. Although uncommon, teratomas should be considered in the differential diagnosis of extragonadal pelvic masses, especially in young adults. [ABSTRACT FROM AUTHOR]

The authors report a case of ovarian hemangioma, a rare tumor of the female genital tract that mimics malignancy. A 23-year-old woman underwent exploratory laparoscopy for a 10-cm right ovarian mass found incidentally. CA125 serum levels were elevated and ascites was noted before surgery. Under suspicion of malignancy, laparoscopic cystectomy and frozen biopsy were performed with the histopathological result of ovarian hemangioma. The authors illustrate an unusual case of this ovarian tumor and its clinicopathological correlation. [ABSTRACT FROM AUTHOR]