1. The influence of menopause and body mass index on serum leptin concentrations
- Author
-
T Bauer, P. Hadji, Klaus-Dieter Schulz, Karin Bock, G. Emons, G Sturm, and O. Hars
- Subjects
Adult ,Leptin ,medicine.medical_specialty ,medicine.drug_class ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Body Mass Index ,Endocrinology ,Internal medicine ,Blood plasma ,medicine ,Humans ,Aged ,Estradiol ,business.industry ,Hormone replacement therapy (menopause) ,General Medicine ,Middle Aged ,medicine.disease ,Obesity ,Menopause ,Blood chemistry ,Estrogen ,Linear Models ,Female ,Follicle Stimulating Hormone ,business ,Body mass index - Abstract
OBJECTIVE: The aim of this study was to evaluate the influence of menopausal status, serum estradiol and body mass index (BMI) on serum leptin concentration in a large sample of pre- and postmenopausal women. DESIGN: 434 healthy women (mean age +/-s.d., 52.2 +/- 10.3 years) were recruited at the University of Marburg on the occasion of a routine gynecological visit. Two hundred and eighteen (50.2%) women were premenopausal (mean age, 36.5 +/- 10.4 years) and not on oral contraceptives or hormone replacement therapy (HRT) and 216 (49.8%) women were postmenopausal (mean age 61.8 +/- 8.9 years) not on HRT. To evaluate the influence of menopausal status, estradiol level and BMI on serum leptin concentrations, women were allocated to one of the four groups: (a) premenopausal women BMI 25 kg/m(2) (n=81), (c) postmenopausal women BMI 25 kg/m(2) (n=122). RESULTS: Irrespective of the menopausal status, women with a BMI >25 kg/m(2) had significantly higher leptin concentrations in all age groups compared with women with a BMI
- Published
- 2000