1. Posterior pituitary (PP) evaluation in patients with anterior pituitary defect associated with ectopic PP and septo-optic dysplasia
- Author
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Andrea Rossi, Anna Elsa Maria Allegri, Mohamad Maghnie, Annalisa Calcagno, Enrica Bertelli, Giovanna Pala, Andrea Secco, Natascia Di Iorgi, Roberto Gastaldi, Flavia Napoli, Stefano Parodi, and Irene Olivieri
- Subjects
Male ,medicine.medical_specialty ,Vasopressin ,Adolescent ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Hypothalamus ,Water-Electrolyte Imbalance ,Choristoma ,Hypopituitarism ,Thirst ,Endocrinology ,Anterior pituitary ,Pituitary Gland, Posterior ,Septo-Optic Dysplasia ,Posterior pituitary ,Internal medicine ,Medicine ,Humans ,Prospective Studies ,Saline ,Saline Solution, Hypertonic ,business.industry ,Osmolar Concentration ,Septo-optic dysplasia ,General Medicine ,medicine.disease ,Magnetic Resonance Imaging ,Plasma osmolality ,Arginine Vasopressin ,medicine.anatomical_structure ,Urine osmolality ,Female ,medicine.symptom ,business - Abstract
ObjectiveControversies exist about posterior pituitary (PP) function in subjects with ectopic PP (EPP) and with cerebral midline defects and/or their co-occurrence. We investigate water and electrolyte disturbances in patients at risk for PP dysfunction.DesignThe study was conducted in a single Pediatric Endocrinology Research Unit.MethodsForty-two subjects with childhood-onset GH deficiency were subdivided into five groups: normal magnetic resonance imaging (n=8, group 1); EPP (n=15, group 2); septo-optic dysplasia (SOD) with normal PP (n=4, group 3); EPP and SOD without (n=7, group 4), and with additional midline brain abnormalities (n=8, group 5). At a mean age of 16.0±1.1 years, they underwent a 120 min i.v. infusion with hypertonic 5% saline and evaluation of plasma osmolality (Posm), arginine vasopressin (AVP), thirst score (in groups 1 and 2), and urinary osmolality were performed.ResultsMean Posm and AVP significantly increased from baseline scores (284.7±4.9 mosm/kg and 0.6±0.2 pmol/l) to 120 min after saline infusion (300.5±8.0 mosm/kg and 10.3±3.3 pmol/l, PPConclusionsPatients with midline brain abnormalities and EPP have defective osmoregulated AVP. Patients with EPP and congenital hypopituitarism have normal PP function.
- Published
- 2011