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Your search keyword '"Chadimová M"' showing total 2 results
Start Over Author "Chadimová M" Journal european journal of drug metabolism and pharmacokinetics
2 results on '"Chadimová M"'

2. Changes in cyclosporine A kinetics after experimental reduction of renal parenchyma

Author

Sedivý J, Bohdanecká M, Chadimová M, K. Matoušovic, Schück O, and M. Krajíčková

Subjects
Male, medicine.medical_specialty, Time Factors, Clinical chemistry, Kinetics, Kidney, urologic and male genital diseases, Nephrectomy, Pharmacokinetics, Oral administration, Internal medicine, Parenchyma, medicine, Animals, Pharmacology (medical), Renal Insufficiency, Pharmacology, business.industry, Ciclosporin, medicine.disease, Rats, Endocrinology, Cyclosporine, Complication, business, Immunosuppressive Agents, medicine.drug, Kidney disease
Abstract

Experimental chronic renal insufficiency (produced by 5/6 ablation of renal parenchyma) is associated with changes in the kinetics of oral (intragastric) cyclosporine A (CyA). Compared with animals with intact renal parenchyma, significantly lower levels of CyA are reached under these conditions. The factors responsible for reduced CyA availability under these conditions have not yet been identified.

Published
1997

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