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Cutaneous angiosarcoma is an aggressive neoplasm that frequently metastasizes to the lungs, a characteristic closely associated with high mortality [1]. Although several chemotherapeutic regimens have been tried, lung metastasis is uncontrollable in almost all cases [2]. We present a case of cutaneous angiosarcoma in which the pulmonary metastasis showed a complete response (CR) to pazopanib treatment. The tumor had a mutation in the transmembrane domain of KIT.A 77-year-old man presented with a [...]

The therapeutic strategies for metastatic melanoma have dramatically changed. Nivolumab, a human monoclonal antibody against programmed cell death 1 (PD-1) and vemurafenib, a selective BRAF inhibitor, have shown clinical efficacy [1, 2]. Although new therapies exist, no consensus on their optimal combination yet exists. Brain metastasis is frequent in patients with advanced melanoma, resulting in poor prognosis, and the median overall survival of these patients is approximately four months [3]. [...]