1. Inflammation profile in overweight/obese adolescents in Europe: an analysis in relation to iron status
- Author
-
Ferrari, M., Cuenca-Garcia, M., Valtuena, J., Moreno, L.A., Censi, L., Gonzalez-Gross, M., Androutsos, O., Gilbert, C.C., Huybrechts, I., Dallongeville, J., Sjostrom, M., Molnar, D., De Henauw, S., Gomez-Martinez, S., de Moraes, A.C.F., Kafatos, A., Widhalm, K., and Leclercq, C.
- Subjects
Physiological aspects ,Obesity -- Physiological aspects ,Inflammation -- Physiological aspects - Abstract
INTRODUCTION There is growing evidence that obesity is characterised by a chronic, low-grade, systemic inflammation (1, 2) that may have a causal role in the development of several diseases such [...], BACKGROUND/OBJECTIVES: The objectives of this study were to investigate the relationship between inflammatory parameters (CRP, c-reactive protein; AGP, [alpha]1-acid glycoprotein), iron status indicators (SF, serum ferritin; sTfR, soluble transferrin receptor) and body mass index (BMI) z-score, fat-free mass (FFM) and fat mass (FM) in European adolescents. Differences in intake for some nutrients (total iron, haem and non-haem iron, vitamin C, calcium, proteins) were assessed according to BMI categories, and the association of nutrient intakes with BMI z-score, FM and FFM was evaluated. METHODS: A total of 876 adolescents participating in the Healthy Lifestyle in Europe by Nutrition in Adolescence-Cross Sectional Study were included in the study sample. RESULTS: Mean CRP values (standard error; s.e.) were significantly higher in overweight/obese adolescents (1.7 [+ or - ] 0.3 and 1.4 [+ or -] 0.3 mg/l in boys and girls, respectively) than in thin/normal-weight adolescents (1.1 [+ or -] 0.2 and 1.0 [+ or -]0.1 mg/l in boys and girls, respectively) (P < 0.05). For boys, mean SF values (s.e.) were significantly higher in overweight/obese adolescents (46.9 [+ or -] 2.7 [micro]g/l) than in thin/normal-weight adolescents (35.7 [+ or -] 1.7 [micro]g/l) (P < 0.001), whereas median sTfR values did not differ among BMI categories for both boys and girls. Multilevel regression analyses showed that BMI z-score and FM were significantly related to CRP and AGP (P < 0.05). Dietary variables did not differ significantly among BMI categories, except for the intake of vegetable proteins, which, for boys, was higher in thin/normal-weight adolescents than in overweight/obese adolescents (P < 0.05). CONCLUSIONS: The adiposity of the European adolescents was sufficient to cause chronic inflammation but not sufficient to impair iron status and cause iron deficiency. European Journal of Clinical Nutrition (2015) 69, 247-255; doi:10.1038/ejcn.2014.154; published online 10 September 2014
- Published
- 2015
- Full Text
- View/download PDF