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Background/Objectives:Consumption of hydroxypropylmethylcellulose (HPMC), a viscous dietary fiber, lowers total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C). However, HPMC had not previously been studied in individuals receiving lipid drug therapy.Subjects/Methods:This randomized, double-blind crossover trial examined the lipid effects of HPMC in subjects with hypercholesterolemia on statin therapy. Men (n=5) and women (n=8) with LDL-C2.59 mmol/l after at least 4 weeks of stable-dose statin therapy, and a mean age of 58.6 years, were enrolled. Subjects received twice daily doses of either 2.5 g HPMC or control, delivered in a lemonade beverage for 4 weeks, then crossed over to receive the opposite treatment for an additional 4 weeks.Results:Mean baseline concentrations of TC, non-high-density lipoprotein cholesterol (non-HDL-C), LDL-C, HDL-C, triglyceride (TG), TC/HDL-C ratio and apolipoprotein (Apo) B were 4.95, 3.63, 3.03, 1.33, 1.30 and 3.89 mmol/l and 1.00 g/l, respectively. HPMC consumption resulted in significantly larger reductions (P<0.01 vs control for all) in TC (−10.9 vs −3.5%), non-HDL-C (−12.8 vs −2.9%), LDL-C (−15.7 vs −5.1%), TC/HDL-C ratio (−5.3 vs +1.3%) and Apo B (−8.7 vs −3.9%). There were no differences between treatments for changes in HDL-C (−5.2 vs −4.3%) or TG (+3.9 vs +8.9%).Conclusions:These results support the view that HPMC is an effective adjunct to statin therapy for further lowering atherogenic lipids and lipoproteins in men and women with primary hypercholesterolemia.European Journal of Clinical Nutrition (2009) 63, 1001–1007; doi:10.1038/ejcn.2009.9; published online 11 February 2009 [ABSTRACT FROM AUTHOR]